Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377010593> ?p ?o ?g. }
- W4377010593 endingPage "70" @default.
- W4377010593 startingPage "63" @default.
- W4377010593 abstract "Abstract: Beyond the time-honoured targeting of protein misfolding and aggregation, Alzheimer’s disease needs new, innovative therapeutic directions. When exploring alternative druggable mechanisms, multifaceted in vitro and in vivo data demonstrate that immune system dysfunction is a pivotal driver of Alzheimer’s disease progression. In pursuing neuroimmunological targets, a major but often under-discussed consideration regards the issue of whether innate or adaptive immunity (or both) within the neuroimmune network should be the centre of focus when devising immunotherapeutic approaches to Alzheimer’s. This perspective article briefly reviews current data, concluding that while both innate and adaptive immunity contributes to the immunopathology of Alzheimer’s, the pro-inflammatory microglia and cytokines of innate immunity will provide higher yield targets with a greater likelihood of efficacy. Although it seems paradoxical to focus on a rapid, short-lived aspect of immunity when seeking approaches to a quintessentially chronic brain disease, accumulating evidence affords ample data to support the target-rich cascade of innate immunity for the development of much-needed new diagnostics and therapeutics." @default.
- W4377010593 created "2023-05-19" @default.
- W4377010593 creator A5005223617 @default.
- W4377010593 date "2023-02-01" @default.
- W4377010593 modified "2023-10-16" @default.
- W4377010593 title "The Immunopathy of Alzheimer’s Disease: Innate or Adaptive?" @default.
- W4377010593 cites W1960212508 @default.
- W4377010593 cites W1966831629 @default.
- W4377010593 cites W1967399741 @default.
- W4377010593 cites W1979987243 @default.
- W4377010593 cites W1991361023 @default.
- W4377010593 cites W1993976394 @default.
- W4377010593 cites W2031299144 @default.
- W4377010593 cites W2033105784 @default.
- W4377010593 cites W2034345831 @default.
- W4377010593 cites W2066039469 @default.
- W4377010593 cites W2074521925 @default.
- W4377010593 cites W2079873627 @default.
- W4377010593 cites W2086383704 @default.
- W4377010593 cites W2094212448 @default.
- W4377010593 cites W2100298346 @default.
- W4377010593 cites W2117324900 @default.
- W4377010593 cites W2128613449 @default.
- W4377010593 cites W2130834754 @default.
- W4377010593 cites W2132576841 @default.
- W4377010593 cites W2134105282 @default.
- W4377010593 cites W2168211203 @default.
- W4377010593 cites W2180559862 @default.
- W4377010593 cites W2218934300 @default.
- W4377010593 cites W2258002535 @default.
- W4377010593 cites W2275744255 @default.
- W4377010593 cites W2291436232 @default.
- W4377010593 cites W2322706669 @default.
- W4377010593 cites W2342031861 @default.
- W4377010593 cites W2407359553 @default.
- W4377010593 cites W2501502116 @default.
- W4377010593 cites W2548767848 @default.
- W4377010593 cites W2786608785 @default.
- W4377010593 cites W2791523793 @default.
- W4377010593 cites W2914822143 @default.
- W4377010593 cites W2916749909 @default.
- W4377010593 cites W2928086185 @default.
- W4377010593 cites W3004262704 @default.
- W4377010593 cites W3033739811 @default.
- W4377010593 cites W3036145585 @default.
- W4377010593 cites W3037473414 @default.
- W4377010593 cites W3138346400 @default.
- W4377010593 cites W3200114640 @default.
- W4377010593 cites W3204794702 @default.
- W4377010593 cites W4206547364 @default.
- W4377010593 cites W4220914263 @default.
- W4377010593 cites W4226141352 @default.
- W4377010593 cites W4296633817 @default.
- W4377010593 cites W4306644813 @default.
- W4377010593 cites W4308332864 @default.
- W4377010593 cites W4308607521 @default.
- W4377010593 cites W4310461604 @default.
- W4377010593 cites W4312194785 @default.
- W4377010593 doi "https://doi.org/10.2174/1567205020666230517103312" @default.
- W4377010593 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37198985" @default.
- W4377010593 hasPublicationYear "2023" @default.
- W4377010593 type Work @default.
- W4377010593 citedByCount "0" @default.
- W4377010593 crossrefType "journal-article" @default.
- W4377010593 hasAuthorship W4377010593A5005223617 @default.
- W4377010593 hasConcept C136449434 @default.
- W4377010593 hasConcept C142724271 @default.
- W4377010593 hasConcept C169760540 @default.
- W4377010593 hasConcept C193419808 @default.
- W4377010593 hasConcept C203014093 @default.
- W4377010593 hasConcept C2776914184 @default.
- W4377010593 hasConcept C2779134260 @default.
- W4377010593 hasConcept C2779341262 @default.
- W4377010593 hasConcept C2779830541 @default.
- W4377010593 hasConcept C502032728 @default.
- W4377010593 hasConcept C71924100 @default.
- W4377010593 hasConcept C86803240 @default.
- W4377010593 hasConcept C8891405 @default.
- W4377010593 hasConceptScore W4377010593C136449434 @default.
- W4377010593 hasConceptScore W4377010593C142724271 @default.
- W4377010593 hasConceptScore W4377010593C169760540 @default.
- W4377010593 hasConceptScore W4377010593C193419808 @default.
- W4377010593 hasConceptScore W4377010593C203014093 @default.
- W4377010593 hasConceptScore W4377010593C2776914184 @default.
- W4377010593 hasConceptScore W4377010593C2779134260 @default.
- W4377010593 hasConceptScore W4377010593C2779341262 @default.
- W4377010593 hasConceptScore W4377010593C2779830541 @default.
- W4377010593 hasConceptScore W4377010593C502032728 @default.
- W4377010593 hasConceptScore W4377010593C71924100 @default.
- W4377010593 hasConceptScore W4377010593C86803240 @default.
- W4377010593 hasConceptScore W4377010593C8891405 @default.
- W4377010593 hasIssue "2" @default.
- W4377010593 hasLocation W43770105931 @default.
- W4377010593 hasLocation W43770105932 @default.
- W4377010593 hasOpenAccess W4377010593 @default.
- W4377010593 hasPrimaryLocation W43770105931 @default.
- W4377010593 hasRelatedWork W2034779847 @default.
- W4377010593 hasRelatedWork W2141330728 @default.