FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377010624> ?p ?o ?g. }

• W4377010624 endingPage "162" @default.
• W4377010624 startingPage "151" @default.
• W4377010624 abstract "Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer. Oncogenic PELP1 is frequently overexpressed in TNBC, and it has been demonstrated that PELP1 signaling is essential for TNBC progression. The therapeutic utility of targeting PELP1 in TNBC, however, remains unknown. In this study, we investigated the effectiveness of SMIP34, a recently developed PELP1 inhibitor for the treatment of TNBC.To ascertain the impact of SMIP34 treatment, we used seven different TNBC models for testing cell viability, colony formation, invasion, apoptosis, and cell cycle analysis. Western blotting and RT-qPCR were used to determine the mechanistic insights of SMIP34 action. Using xenograft and PDX tumors, the ability of SMIP34 in suppressing proliferation was examined both ex vivo and in vivo.TNBC cells' viability, colony formation, and invasiveness were all decreased by SMIP34 in in vitro cell-based assays, while apoptosis was increased. SMIP34 treatment promoted the degradation of PELP1 through the proteasome pathway. RT-qPCR analyses confirmed that SMIP34 treatment downregulated PELP1 target genes. Further, SMIP34 treatment substantially downregulated PELP1 mediated extranuclear signaling including ERK, mTOR, S6 and 4EBP1. Mechanistic studies confirmed downregulation of PELP1 mediated ribosomal biogenesis functions including downregulation of cMyc and Rix complex proteins LAS1L, TEX-10, and SENP3. The proliferation of TNBC tumor tissues was decreased in explant experiments by SMIP34. Additionally, SMIP34 treatment markedly decreased tumor progression in both TNBC xenograft and PDX models.Together, these findings from in vitro, ex vivo, and in vivo models show that SMIP34 may be a useful therapeutic agent for inhibiting PELP1 signaling in TNBC." @default.
• W4377010624 created "2023-05-19" @default.
• W4377010624 creator A5020865378 @default.
• W4377010624 creator A5022585394 @default.
• W4377010624 creator A5043867874 @default.
• W4377010624 creator A5045699506 @default.
• W4377010624 creator A5047633611 @default.
• W4377010624 creator A5060628869 @default.
• W4377010624 creator A5060877175 @default.
• W4377010624 creator A5064393266 @default.
• W4377010624 creator A5078304350 @default.
• W4377010624 creator A5079514337 @default.
• W4377010624 creator A5081127817 @default.
• W4377010624 creator A5081244737 @default.
• W4377010624 creator A5090010000 @default.
• W4377010624 date "2023-05-18" @default.
• W4377010624 modified "2023-10-11" @default.
• W4377010624 title "Targeting PELP1 oncogenic signaling in TNBC with the small molecule inhibitor SMIP34" @default.
• W4377010624 cites W1120703826 @default.
• W4377010624 cites W1964480899 @default.
• W4377010624 cites W1969346276 @default.
• W4377010624 cites W1995573963 @default.
• W4377010624 cites W2001981679 @default.
• W4377010624 cites W2023958693 @default.
• W4377010624 cites W2028884946 @default.
• W4377010624 cites W2030781089 @default.
• W4377010624 cites W2042976485 @default.
• W4377010624 cites W2044702943 @default.
• W4377010624 cites W2072613049 @default.
• W4377010624 cites W2076292729 @default.
• W4377010624 cites W2096027508 @default.
• W4377010624 cites W2096283457 @default.
• W4377010624 cites W2097599440 @default.
• W4377010624 cites W2116473907 @default.
• W4377010624 cites W2147934525 @default.
• W4377010624 cites W2152530485 @default.
• W4377010624 cites W2154478723 @default.
• W4377010624 cites W2155871333 @default.
• W4377010624 cites W2174467138 @default.
• W4377010624 cites W2300860717 @default.
• W4377010624 cites W2402636472 @default.
• W4377010624 cites W2546735327 @default.
• W4377010624 cites W2560367415 @default.
• W4377010624 cites W2947010413 @default.
• W4377010624 cites W2997462523 @default.
• W4377010624 cites W3128646645 @default.
• W4377010624 cites W4213004139 @default.
• W4377010624 cites W4290804033 @default.
• W4377010624 cites W4308653678 @default.
• W4377010624 doi "https://doi.org/10.1007/s10549-023-06958-4" @default.
• W4377010624 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37199805" @default.
• W4377010624 hasPublicationYear "2023" @default.
• W4377010624 type Work @default.
• W4377010624 citedByCount "0" @default.
• W4377010624 crossrefType "journal-article" @default.
• W4377010624 hasAuthorship W4377010624A5020865378 @default.
• W4377010624 hasAuthorship W4377010624A5022585394 @default.
• W4377010624 hasAuthorship W4377010624A5043867874 @default.
• W4377010624 hasAuthorship W4377010624A5045699506 @default.
• W4377010624 hasAuthorship W4377010624A5047633611 @default.
• W4377010624 hasAuthorship W4377010624A5060628869 @default.
• W4377010624 hasAuthorship W4377010624A5060877175 @default.
• W4377010624 hasAuthorship W4377010624A5064393266 @default.
• W4377010624 hasAuthorship W4377010624A5078304350 @default.
• W4377010624 hasAuthorship W4377010624A5079514337 @default.
• W4377010624 hasAuthorship W4377010624A5081127817 @default.
• W4377010624 hasAuthorship W4377010624A5081244737 @default.
• W4377010624 hasAuthorship W4377010624A5090010000 @default.
• W4377010624 hasBestOaLocation W43770106241 @default.
• W4377010624 hasConcept C104317684 @default.
• W4377010624 hasConcept C121608353 @default.
• W4377010624 hasConcept C127561419 @default.
• W4377010624 hasConcept C150903083 @default.
• W4377010624 hasConcept C190283241 @default.
• W4377010624 hasConcept C207001950 @default.
• W4377010624 hasConcept C26291073 @default.
• W4377010624 hasConcept C2780110267 @default.
• W4377010624 hasConcept C502942594 @default.
• W4377010624 hasConcept C530470458 @default.
• W4377010624 hasConcept C53227056 @default.
• W4377010624 hasConcept C54355233 @default.
• W4377010624 hasConcept C55493867 @default.
• W4377010624 hasConcept C57074206 @default.
• W4377010624 hasConcept C62112901 @default.
• W4377010624 hasConcept C62478195 @default.
• W4377010624 hasConcept C86554907 @default.
• W4377010624 hasConcept C86803240 @default.
• W4377010624 hasConcept C95444343 @default.
• W4377010624 hasConceptScore W4377010624C104317684 @default.
• W4377010624 hasConceptScore W4377010624C121608353 @default.
• W4377010624 hasConceptScore W4377010624C127561419 @default.
• W4377010624 hasConceptScore W4377010624C150903083 @default.
• W4377010624 hasConceptScore W4377010624C190283241 @default.
• W4377010624 hasConceptScore W4377010624C207001950 @default.
• W4377010624 hasConceptScore W4377010624C26291073 @default.
• W4377010624 hasConceptScore W4377010624C2780110267 @default.
• W4377010624 hasConceptScore W4377010624C502942594 @default.
• W4377010624 hasConceptScore W4377010624C530470458 @default.

• next