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- W4377010786 endingPage "1400" @default.
- W4377010786 startingPage "1390" @default.
- W4377010786 abstract "The intestinal mucus layer is a barrier that separates intestinal contents and epithelial cells, as well as acts as the mucus layer-soil for intestinal flora adhesion and colonization. Its structural and functional integrity is crucial to human health. Intestinal mucus is regulated by factors such as diet, living habits, hormones, neurotransmitters, cytokines, and intestinal flora. The mucus layer's thickness, viscosity, porosity, growth rate, and glycosylation status affect the structure of the gut flora colonized on it. The interaction between mucus layer-soil and gut bacteria-seed is an important factor leading to the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Probiotics, prebiotics, fecal microbiota transplantation (FMT), and wash microbial transplantation are efficient methods for managing NAFLD, but their long-term efficacy is poor. FMT is focused on achieving the goal of treating diseases by enhancing the gut bacteria-seed. However, a lack of effective repair and management of the mucus layer-soil may be a reason why seeds cannot be well colonized and grow in the host gut, as the thinning and destruction of the mucus layer-soil is an early symptom of NAFLD. This review summarizes the existing correlation between intestinal mucus and gut microbiota, as well as the pathogenesis of NAFLD, and proposes a new perspective that mucus layer-soil restoration combined with gut bacteria-seed FMT may be one of the most effective future strategies for enhancing the long-term efficacy of NAFLD treatment." @default.
- W4377010786 created "2023-05-19" @default.
- W4377010786 creator A5006636063 @default.
- W4377010786 creator A5034139304 @default.
- W4377010786 creator A5036148802 @default.
- W4377010786 creator A5043364506 @default.
- W4377010786 creator A5082394101 @default.
- W4377010786 creator A5083222383 @default.
- W4377010786 date "2023-05-18" @default.
- W4377010786 modified "2023-09-26" @default.
- W4377010786 title "Interaction between mucus layer and gut microbiota in non-alcoholic fatty liver disease: Soil and seeds" @default.
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