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- W4377010812 abstract "In the last few months new results in Alzheimer's (AD) and Parkinson's disease (PD) have converged, attracting attention to oligomer species of misfolded proteins, β-amyloid (Aβ and α-synuclein (α-Syn), in the pathogenesis. The high affinity for Aβ protofibrils and oligomers of lecanemab, an antibody recently approved as a disease-modifying drug in AD, and the identification of Aβ-oligomers in blood samples as early biomarkers in subjects with cognitive decline, indicate the oligomers as a therapeutic target and diagnostic tool in AD. α-Syn oligomers were identified by new histopathological techniques in the hippocampus and visual cortex of PD subjects with a distribution distinct from the Lewy body pathologies but associated with cognitive impairment; these species purified from PD brain were highly neurotoxic. In a PD experimental model, we confirmed the presence of α-Syn oligomers associated with cognitive decline and sensitive to drug treatment." @default.
- W4377010812 created "2023-05-19" @default.
- W4377010812 creator A5084544899 @default.
- W4377010812 date "2023-01-01" @default.
- W4377010812 modified "2023-09-28" @default.
- W4377010812 title "Oligomers and Neurodegeneration: New Evidence" @default.
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- W4377010812 doi "https://doi.org/10.14336/ad.2023.0327" @default.
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