Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377010828> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W4377010828 endingPage "240" @default.
- W4377010828 startingPage "234" @default.
- W4377010828 abstract "Circulating tumour cells (CTCs) are related to poor prognosis in hepatobiliary cancers, including hepatocellular carcinoma and gallbladder carcinoma, but their value in intrahepatic cholangiocarcinoma (ICC) is obscure. This study aimed to investigate the change in CTCs during chemotherapy and its correlation with clinical features, treatment response and survival profile in advanced ICC patients. Fifty-one unresectable, advanced ICC patients who underwent chemotherapy were consecutively enrolled. Peripheral blood samples were collected at diagnosis and 2 months (M2) after chemotherapy initiation for CTC detection via the ISET method. The mean and median CTC counts at diagnosis were 7.4 ± 12.2 and 4.0 (range: 0.0-68.0), respectively, with 92.2% of patients having more than one CTC. A higher CTC count at diagnosis was correlated with elevated lymph node metastasis (p = 0.005), distant metastasis (p = 0.005) and TNM stage (p = 0.001) but no other characteristics. In addition, the CTC count at diagnosis was higher in nonobjective-response patients than in objective-response patients (p = 0.002), and a CTC count at diagnosis above 3 correlated with worse progression-free survival (PFS) (p = 0.007) and overall survival (OS) (p = 0.036). At M2, the CTC count was greatly decreased (p < 0.001). CTC count at M2 also correlated with lower treatment response (p < 0.001), and CTC counts above 3 were associated with poor PFS (p = 0.003) and OS (p = 0.017). After multivariate Cox analyses, CTC counts at diagnosis above 3 and CTC count increase from diagnosis to M2 independently predicted PFS and OS (p < 0.05). Detection of CTCs before and during chemotherapy is useful for prognostication in advanced ICC patients." @default.
- W4377010828 created "2023-05-19" @default.
- W4377010828 creator A5010732611 @default.
- W4377010828 creator A5028873497 @default.
- W4377010828 creator A5037519294 @default.
- W4377010828 date "2023-05-18" @default.
- W4377010828 modified "2023-09-27" @default.
- W4377010828 title "Longitudinal change of circulating tumour cell count and its relation to prognosis in advanced intrahepatic cholangiocarcinoma patients" @default.
- W4377010828 cites W1558034062 @default.
- W4377010828 cites W1994356780 @default.
- W4377010828 cites W2019607817 @default.
- W4377010828 cites W2115261608 @default.
- W4377010828 cites W2152278540 @default.
- W4377010828 cites W2170424652 @default.
- W4377010828 cites W2916978683 @default.
- W4377010828 cites W2937317161 @default.
- W4377010828 cites W2946873076 @default.
- W4377010828 cites W2964959405 @default.
- W4377010828 cites W2977982707 @default.
- W4377010828 cites W2983279601 @default.
- W4377010828 cites W2995789688 @default.
- W4377010828 cites W3005408377 @default.
- W4377010828 cites W3019595514 @default.
- W4377010828 cites W3033864616 @default.
- W4377010828 cites W3042257765 @default.
- W4377010828 cites W3097419955 @default.
- W4377010828 cites W3119630053 @default.
- W4377010828 cites W3128646645 @default.
- W4377010828 cites W3133576252 @default.
- W4377010828 cites W3134450010 @default.
- W4377010828 cites W3135370244 @default.
- W4377010828 cites W3136824869 @default.
- W4377010828 cites W3158971361 @default.
- W4377010828 cites W3160992791 @default.
- W4377010828 cites W3165575280 @default.
- W4377010828 cites W3183375819 @default.
- W4377010828 cites W4205455149 @default.
- W4377010828 cites W4206987062 @default.
- W4377010828 cites W4210953361 @default.
- W4377010828 doi "https://doi.org/10.1080/00365513.2023.2206048" @default.
- W4377010828 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37199131" @default.
- W4377010828 hasPublicationYear "2023" @default.
- W4377010828 type Work @default.
- W4377010828 citedByCount "0" @default.
- W4377010828 crossrefType "journal-article" @default.
- W4377010828 hasAuthorship W4377010828A5010732611 @default.
- W4377010828 hasAuthorship W4377010828A5028873497 @default.
- W4377010828 hasAuthorship W4377010828A5037519294 @default.
- W4377010828 hasConcept C121608353 @default.
- W4377010828 hasConcept C126322002 @default.
- W4377010828 hasConcept C143998085 @default.
- W4377010828 hasConcept C146357865 @default.
- W4377010828 hasConcept C151730666 @default.
- W4377010828 hasConcept C2776694085 @default.
- W4377010828 hasConcept C2778019345 @default.
- W4377010828 hasConcept C2779013556 @default.
- W4377010828 hasConcept C2909135397 @default.
- W4377010828 hasConcept C71924100 @default.
- W4377010828 hasConcept C86803240 @default.
- W4377010828 hasConcept C90924648 @default.
- W4377010828 hasConceptScore W4377010828C121608353 @default.
- W4377010828 hasConceptScore W4377010828C126322002 @default.
- W4377010828 hasConceptScore W4377010828C143998085 @default.
- W4377010828 hasConceptScore W4377010828C146357865 @default.
- W4377010828 hasConceptScore W4377010828C151730666 @default.
- W4377010828 hasConceptScore W4377010828C2776694085 @default.
- W4377010828 hasConceptScore W4377010828C2778019345 @default.
- W4377010828 hasConceptScore W4377010828C2779013556 @default.
- W4377010828 hasConceptScore W4377010828C2909135397 @default.
- W4377010828 hasConceptScore W4377010828C71924100 @default.
- W4377010828 hasConceptScore W4377010828C86803240 @default.
- W4377010828 hasConceptScore W4377010828C90924648 @default.
- W4377010828 hasIssue "4" @default.
- W4377010828 hasLocation W43770108281 @default.
- W4377010828 hasLocation W43770108282 @default.
- W4377010828 hasOpenAccess W4377010828 @default.
- W4377010828 hasPrimaryLocation W43770108281 @default.
- W4377010828 hasRelatedWork W1987468340 @default.
- W4377010828 hasRelatedWork W2045055624 @default.
- W4377010828 hasRelatedWork W2095435148 @default.
- W4377010828 hasRelatedWork W2100879300 @default.
- W4377010828 hasRelatedWork W2300188460 @default.
- W4377010828 hasRelatedWork W2370316128 @default.
- W4377010828 hasRelatedWork W2559850096 @default.
- W4377010828 hasRelatedWork W3029220886 @default.
- W4377010828 hasRelatedWork W3143191004 @default.
- W4377010828 hasRelatedWork W4240236077 @default.
- W4377010828 hasVolume "83" @default.
- W4377010828 isParatext "false" @default.
- W4377010828 isRetracted "false" @default.
- W4377010828 workType "article" @default.