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- W4377010882 abstract "Abstract To study how natural allelic variation explains quantitative developmental system variation, we characterized natural differences in germ stem cell niche activity, measured as progenitor zone (PZ) size, between two Caenorhabditis elegans isolates. Linkage mapping yielded candidate loci on chromosomes II and V, and we found that the isolate with a smaller PZ size harbours a 148 bp promoter deletion in the Notch ligand, lag-2/Delta , a central signal promoting germ stem cell fate. As predicted, introducing this deletion into the isolate with a large PZ resulted in a smaller PZ size. Unexpectedly, restoring the deleted ancestral sequence in the isolate with a smaller PZ did not increase—but instead further reduced—PZ size. These seemingly contradictory phenotypic effects are explained by epistatic interactions between the lag-2/Delta promoter, the chromosome II locus, and additional background loci. These results provide first insights into the quantitative genetic architecture regulating an animal stem cell system." @default.
- W4377010882 created "2023-05-19" @default.
- W4377010882 creator A5016785503 @default.
- W4377010882 creator A5037481678 @default.
- W4377010882 creator A5058848456 @default.
- W4377010882 creator A5088213434 @default.
- W4377010882 date "2023-05-17" @default.
- W4377010882 modified "2023-09-30" @default.
- W4377010882 title "Higher-order epistasis shapes natural variation in germ stem cell niche activity" @default.
- W4377010882 cites W1513618424 @default.
- W4377010882 cites W159496740 @default.
- W4377010882 cites W1712039008 @default.
- W4377010882 cites W182543335 @default.
- W4377010882 cites W1837161037 @default.
- W4377010882 cites W1918050351 @default.
- W4377010882 cites W1944127002 @default.
- W4377010882 cites W1964128403 @default.
- W4377010882 cites W1964419985 @default.
- W4377010882 cites W1966676631 @default.
- W4377010882 cites W1979220616 @default.
- W4377010882 cites W1985717957 @default.
- W4377010882 cites W1991840483 @default.
- W4377010882 cites W1993306613 @default.
- W4377010882 cites W1994352982 @default.
- W4377010882 cites W2001348829 @default.
- W4377010882 cites W2010097127 @default.
- W4377010882 cites W2011705026 @default.
- W4377010882 cites W2017392540 @default.
- W4377010882 cites W2022636987 @default.
- W4377010882 cites W2025341853 @default.
- W4377010882 cites W2029918259 @default.
- W4377010882 cites W2037084575 @default.
- W4377010882 cites W2051463060 @default.
- W4377010882 cites W2066709956 @default.
- W4377010882 cites W2072214908 @default.
- W4377010882 cites W2073171022 @default.
- W4377010882 cites W2075269611 @default.
- W4377010882 cites W2076724997 @default.
- W4377010882 cites W2079319076 @default.
- W4377010882 cites W2088009035 @default.
- W4377010882 cites W2091345755 @default.
- W4377010882 cites W2094189284 @default.
- W4377010882 cites W2097523066 @default.
- W4377010882 cites W2097579478 @default.
- W4377010882 cites W2098085839 @default.
- W4377010882 cites W2099540110 @default.
- W4377010882 cites W2100365580 @default.
- W4377010882 cites W2101011308 @default.
- W4377010882 cites W2105241495 @default.
- W4377010882 cites W2110612987 @default.
- W4377010882 cites W2112991137 @default.
- W4377010882 cites W2120998017 @default.
- W4377010882 cites W2122603348 @default.
- W4377010882 cites W2126015874 @default.
- W4377010882 cites W2126998616 @default.
- W4377010882 cites W2128523604 @default.
- W4377010882 cites W2129514419 @default.
- W4377010882 cites W2138292740 @default.
- W4377010882 cites W2139956822 @default.
- W4377010882 cites W2140723001 @default.
- W4377010882 cites W2157240032 @default.
- W4377010882 cites W2157308673 @default.
- W4377010882 cites W2162156317 @default.
- W4377010882 cites W2162448144 @default.
- W4377010882 cites W2163813446 @default.
- W4377010882 cites W2163937097 @default.
- W4377010882 cites W2164221181 @default.
- W4377010882 cites W2167901914 @default.
- W4377010882 cites W2168037097 @default.
- W4377010882 cites W2176482588 @default.
- W4377010882 cites W2236822702 @default.
- W4377010882 cites W2311431697 @default.
- W4377010882 cites W2337811941 @default.
- W4377010882 cites W2462242997 @default.
- W4377010882 cites W2466877915 @default.
- W4377010882 cites W2507679497 @default.
- W4377010882 cites W2519628283 @default.
- W4377010882 cites W2529350482 @default.
- W4377010882 cites W2550361691 @default.
- W4377010882 cites W2594728656 @default.
- W4377010882 cites W2594760713 @default.
- W4377010882 cites W2613291854 @default.
- W4377010882 cites W2626606138 @default.
- W4377010882 cites W2749953799 @default.
- W4377010882 cites W2786358356 @default.
- W4377010882 cites W2804233742 @default.
- W4377010882 cites W2888916332 @default.
- W4377010882 cites W2925562378 @default.
- W4377010882 cites W2949442799 @default.
- W4377010882 cites W2951666765 @default.
- W4377010882 cites W2951758386 @default.
- W4377010882 cites W2972766454 @default.
- W4377010882 cites W2989950764 @default.
- W4377010882 cites W2990427812 @default.
- W4377010882 cites W2992563067 @default.
- W4377010882 cites W3012129213 @default.
- W4377010882 cites W3044761418 @default.
- W4377010882 cites W3049133966 @default.
- W4377010882 cites W3082051948 @default.
- W4377010882 cites W3084250643 @default.