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- W4377010902 abstract "The standard preparative regimen for autologous stem cell transplant (ASCT) in multiple myeloma (MM) is 200 mg/m2 of intravenous melphalan; however, a dose of 140 mg/m2 is often used when concerns exist related to patient age, performance status, organ function, and other factors. It is unclear whether a lower dose of melphalan impacts post-transplant survival outcomes. We performed a retrospective review of 930 patients with MM who underwent ASCT with 200 mg/m2 versus 140 mg/m2 melphalan. On univariable analysis, no difference in progression-free survival (PFS) was observed, however, an overall survival (OS) benefit was observed in patients receiving 200 mg/m2 melphalan (p = 0.04). Multivariable analyses showed patients receiving 140 mg/m2 faired no worse than those receiving 200 mg/m2. While a subset of younger patients with normal renal function may achieve superior OS with a standard dose of 200 mg/m2 melphalan, these findings suggest an opportunity to individualize the ASCT preparative regimen to optimize outcomes." @default.
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- W4377010902 date "2023-05-18" @default.
- W4377010902 modified "2023-09-27" @default.
- W4377010902 title "Survival outcomes following autologous stem cell transplant with melphalan 140mg/m<sup>2</sup> versus 200mg/m<sup>2</sup> preparative regimens in patients with multiple myeloma" @default.
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- W4377010902 doi "https://doi.org/10.1080/10428194.2023.2213366" @default.
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