Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377010912> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W4377010912 endingPage "636" @default.
- W4377010912 startingPage "631" @default.
- W4377010912 abstract "Background: This study aimed to compare the achievement of pharmacokinetic–pharmacodynamic (PK-PD) exposure targets for vancomycin using a newly developed dosing guideline with product-information-based dosing in the treatment of adult patients with serious infections. Methods: In silico product-information- and guideline-based dosing simulations for vancomycin were performed across a range of doses and patient characteristics, including body weight, age, and renal function at 36–48 and 96 hours, using a pharmacokinetic model derived from a seriously ill patient population. The median simulated concentration and area under the 24-hour concentration–time curve (AUC 0-24 ) were used to measure predefined therapeutic, subtherapeutic, and toxicity PK-PD targets. Results: Ninety-six dosing simulations were performed. The pooled median trough concentration target with guideline-based dosing at 36 and 96 hours was achieved in 27.1% (13/48) and 8.3% (7/48) of simulations, respectively. The pooled median AUC 0-24 /minimum inhibitory concentration ratio with guideline-based dosing at 48 and 96 hours was attained in 39.6% (19/48) and 27.1% (13/48) of simulations, respectively. Guideline-based dosing simulations yielded improved trough target attainment compared with product-information-based dosing at 36 hours and significantly less subtherapeutic drug exposure. The toxicity threshold was exceeded in 52.1% (25/48) and 0% (0/48) for guideline- and product-information-information-based dosing, respectively ( P < 0.001). Conclusions: A Critical care vancomycin dosing guideline appeared slightly more effective than standard dosing, as per product information, in achieving PK-PD exposure associated with an increased likelihood of effectiveness. In addition, this guideline significantly reduced the risk of subtherapeutic exposure. The risk of exceeding toxicity thresholds, however, was greater with the guideline, and further investigation is suggested to improve dosing accuracy and sensitivity." @default.
- W4377010912 created "2023-05-19" @default.
- W4377010912 creator A5005119582 @default.
- W4377010912 creator A5019350618 @default.
- W4377010912 creator A5023993805 @default.
- W4377010912 creator A5042693942 @default.
- W4377010912 creator A5043218702 @default.
- W4377010912 creator A5091615543 @default.
- W4377010912 date "2023-05-02" @default.
- W4377010912 modified "2023-10-08" @default.
- W4377010912 title "In silico Evaluation of a Vancomycin Dosing Guideline Among Adults with Serious Infections" @default.
- W4377010912 cites W1789064953 @default.
- W4377010912 cites W1977408435 @default.
- W4377010912 cites W1977578039 @default.
- W4377010912 cites W2015225568 @default.
- W4377010912 cites W2037594369 @default.
- W4377010912 cites W2076664566 @default.
- W4377010912 cites W2085135140 @default.
- W4377010912 cites W2104779095 @default.
- W4377010912 cites W2105064679 @default.
- W4377010912 cites W2109144391 @default.
- W4377010912 cites W2126301019 @default.
- W4377010912 cites W2134710982 @default.
- W4377010912 cites W2134944593 @default.
- W4377010912 cites W2155965977 @default.
- W4377010912 cites W2161342563 @default.
- W4377010912 cites W2297596467 @default.
- W4377010912 cites W2442246762 @default.
- W4377010912 cites W2746050631 @default.
- W4377010912 cites W2765727798 @default.
- W4377010912 cites W2774974184 @default.
- W4377010912 cites W2911800540 @default.
- W4377010912 cites W2987307066 @default.
- W4377010912 cites W3022327571 @default.
- W4377010912 cites W3039071397 @default.
- W4377010912 cites W3042308820 @default.
- W4377010912 doi "https://doi.org/10.1097/ftd.0000000000001102" @default.
- W4377010912 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37199397" @default.
- W4377010912 hasPublicationYear "2023" @default.
- W4377010912 type Work @default.
- W4377010912 citedByCount "0" @default.
- W4377010912 crossrefType "journal-article" @default.
- W4377010912 hasAuthorship W4377010912A5005119582 @default.
- W4377010912 hasAuthorship W4377010912A5019350618 @default.
- W4377010912 hasAuthorship W4377010912A5023993805 @default.
- W4377010912 hasAuthorship W4377010912A5042693942 @default.
- W4377010912 hasAuthorship W4377010912A5043218702 @default.
- W4377010912 hasAuthorship W4377010912A5091615543 @default.
- W4377010912 hasConcept C111113717 @default.
- W4377010912 hasConcept C112705442 @default.
- W4377010912 hasConcept C142724271 @default.
- W4377010912 hasConcept C177713679 @default.
- W4377010912 hasConcept C2777288759 @default.
- W4377010912 hasConcept C2778980435 @default.
- W4377010912 hasConcept C2779489039 @default.
- W4377010912 hasConcept C2780182762 @default.
- W4377010912 hasConcept C2780272996 @default.
- W4377010912 hasConcept C523546767 @default.
- W4377010912 hasConcept C54355233 @default.
- W4377010912 hasConcept C71924100 @default.
- W4377010912 hasConcept C86803240 @default.
- W4377010912 hasConcept C98274493 @default.
- W4377010912 hasConceptScore W4377010912C111113717 @default.
- W4377010912 hasConceptScore W4377010912C112705442 @default.
- W4377010912 hasConceptScore W4377010912C142724271 @default.
- W4377010912 hasConceptScore W4377010912C177713679 @default.
- W4377010912 hasConceptScore W4377010912C2777288759 @default.
- W4377010912 hasConceptScore W4377010912C2778980435 @default.
- W4377010912 hasConceptScore W4377010912C2779489039 @default.
- W4377010912 hasConceptScore W4377010912C2780182762 @default.
- W4377010912 hasConceptScore W4377010912C2780272996 @default.
- W4377010912 hasConceptScore W4377010912C523546767 @default.
- W4377010912 hasConceptScore W4377010912C54355233 @default.
- W4377010912 hasConceptScore W4377010912C71924100 @default.
- W4377010912 hasConceptScore W4377010912C86803240 @default.
- W4377010912 hasConceptScore W4377010912C98274493 @default.
- W4377010912 hasIssue "5" @default.
- W4377010912 hasLocation W43770109121 @default.
- W4377010912 hasLocation W43770109122 @default.
- W4377010912 hasOpenAccess W4377010912 @default.
- W4377010912 hasPrimaryLocation W43770109121 @default.
- W4377010912 hasRelatedWork W1911417339 @default.
- W4377010912 hasRelatedWork W2378907788 @default.
- W4377010912 hasRelatedWork W2537946321 @default.
- W4377010912 hasRelatedWork W2779877011 @default.
- W4377010912 hasRelatedWork W3138397568 @default.
- W4377010912 hasRelatedWork W4213414504 @default.
- W4377010912 hasRelatedWork W4221095273 @default.
- W4377010912 hasRelatedWork W4223534033 @default.
- W4377010912 hasRelatedWork W4318966470 @default.
- W4377010912 hasRelatedWork W4367175696 @default.
- W4377010912 hasVolume "45" @default.
- W4377010912 isParatext "false" @default.
- W4377010912 isRetracted "false" @default.
- W4377010912 workType "article" @default.