FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377010947> ?p ?o ?g. }

• W4377010947 endingPage "2179" @default.
• W4377010947 startingPage "2154" @default.
• W4377010947 abstract "Parkinson's disease (PD) is the most common neurodegenerative movement disorder worldwide, with a greater prevalence in men than women. The etiology of PD is largely unknown, although environmental exposures and neuroinflammation are linked to protein misfolding and disease progression. Activated microglia are known to promote neuroinflammation in PD, but how environmental agents interact with specific innate immune signaling pathways in microglia to stimulate conversion to a neurotoxic phenotype is not well understood. To determine how nuclear factor kappa B (NF-κB) signaling dynamics in microglia modulate neuroinflammation and dopaminergic neurodegeneration, we generated mice deficient in NF-κB activation in microglia (CX3CR1-Cre::IKK2fl/fl ) and exposed them to 2.5 mg/kg/day of rotenone for 14 days, followed by a 14-day post-lesioning incubation period. We postulated that inhibition of NF-κB signaling in microglia would reduce overall inflammatory injury in lesioned mice. Subsequent analysis indicated decreased expression of the NF-κB-regulated autophagy gene, sequestosome 1 (p62), in microglia, which is required for targeting ubiquitinated α-synuclein (α-syn) for lysosomal degradation. Knock-out animals had increased accumulation of misfolded α-syn within microglia, despite an overall reduction in neurodegeneration. Interestingly, this occurred more prominently in males. These data suggest that microglia play key biological roles in the degradation and clearance of misfolded α-syn and this process works in concert with the innate immune response associated with neuroinflammation. Importantly, the accumulation of misfolded α-syn protein aggregates alone did not increase neurodegeneration following exposure to rotenone but required the NF-κB-dependent inflammatory response in microglia." @default.
• W4377010947 created "2023-05-19" @default.
• W4377010947 creator A5002274261 @default.
• W4377010947 creator A5033088761 @default.
• W4377010947 creator A5036017665 @default.
• W4377010947 creator A5049962094 @default.
• W4377010947 creator A5058143660 @default.
• W4377010947 creator A5060040709 @default.
• W4377010947 date "2023-05-18" @default.
• W4377010947 modified "2023-10-15" @default.
• W4377010947 title "Microglia‐specific knock‐out of <scp>NF‐κB</scp>/<scp>IKK2</scp> increases the accumulation of misfolded α‐synuclein through the inhibition of p62/<scp>sequestosome</scp>‐1‐dependent autophagy in the rotenone model of Parkinson's disease" @default.
• W4377010947 cites W1517251865 @default.
• W4377010947 cites W1527671059 @default.
• W4377010947 cites W1558190835 @default.
• W4377010947 cites W1575298809 @default.
• W4377010947 cites W1593033681 @default.
• W4377010947 cites W1617495083 @default.
• W4377010947 cites W1761627028 @default.
• W4377010947 cites W1923453730 @default.
• W4377010947 cites W1965942744 @default.
• W4377010947 cites W1972646996 @default.
• W4377010947 cites W1974924674 @default.
• W4377010947 cites W1977682751 @default.
• W4377010947 cites W1979591162 @default.
• W4377010947 cites W1979883589 @default.
• W4377010947 cites W1980845575 @default.
• W4377010947 cites W1986625112 @default.
• W4377010947 cites W1995042437 @default.
• W4377010947 cites W1995191747 @default.
• W4377010947 cites W1996024251 @default.
• W4377010947 cites W1996241541 @default.
• W4377010947 cites W2001176185 @default.
• W4377010947 cites W2003674452 @default.
• W4377010947 cites W2006497054 @default.
• W4377010947 cites W2009525838 @default.
• W4377010947 cites W2016818296 @default.
• W4377010947 cites W2018244586 @default.
• W4377010947 cites W2019933368 @default.
• W4377010947 cites W2028911868 @default.
• W4377010947 cites W2029503022 @default.
• W4377010947 cites W2031427673 @default.
• W4377010947 cites W2045325214 @default.
• W4377010947 cites W2051097977 @default.
• W4377010947 cites W2056546282 @default.
• W4377010947 cites W2074551097 @default.
• W4377010947 cites W2075527716 @default.
• W4377010947 cites W2084562439 @default.
• W4377010947 cites W2085662515 @default.
• W4377010947 cites W2090409342 @default.
• W4377010947 cites W2092918356 @default.
• W4377010947 cites W2095279106 @default.
• W4377010947 cites W2106022949 @default.
• W4377010947 cites W2106911268 @default.
• W4377010947 cites W2109128386 @default.
• W4377010947 cites W2114431124 @default.
• W4377010947 cites W2127726976 @default.
• W4377010947 cites W2146901670 @default.
• W4377010947 cites W2147830608 @default.
• W4377010947 cites W2151283331 @default.
• W4377010947 cites W2172296192 @default.
• W4377010947 cites W2464977649 @default.
• W4377010947 cites W2497241389 @default.
• W4377010947 cites W2501464909 @default.
• W4377010947 cites W2539841050 @default.
• W4377010947 cites W2572710398 @default.
• W4377010947 cites W2584311212 @default.
• W4377010947 cites W2592913785 @default.
• W4377010947 cites W2611861607 @default.
• W4377010947 cites W2729865284 @default.
• W4377010947 cites W2735527928 @default.
• W4377010947 cites W2736913135 @default.
• W4377010947 cites W2790853064 @default.
• W4377010947 cites W2795566161 @default.
• W4377010947 cites W2800399031 @default.
• W4377010947 cites W2802616779 @default.
• W4377010947 cites W2811255424 @default.
• W4377010947 cites W2887497469 @default.
• W4377010947 cites W2890627020 @default.
• W4377010947 cites W2890637781 @default.
• W4377010947 cites W2890847880 @default.
• W4377010947 cites W2911840604 @default.
• W4377010947 cites W2918112026 @default.
• W4377010947 cites W2920814653 @default.
• W4377010947 cites W2936059353 @default.
• W4377010947 cites W2945594004 @default.
• W4377010947 cites W2946924931 @default.
• W4377010947 cites W2955533479 @default.
• W4377010947 cites W2972589620 @default.
• W4377010947 cites W2981496982 @default.
• W4377010947 cites W3002284659 @default.
• W4377010947 cites W3006172490 @default.
• W4377010947 cites W3006730132 @default.
• W4377010947 cites W3011306000 @default.
• W4377010947 cites W3013963964 @default.
• W4377010947 cites W3015405891 @default.
• W4377010947 cites W3015663834 @default.
• W4377010947 cites W3042580583 @default.
• W4377010947 cites W3044416402 @default.

• next