Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377010967> ?p ?o ?g. }
- W4377010967 abstract "Cancer-testis genes are involved in the occurrence and development of cancer, but the role of cancer-testis-associated lncRNAs (CT-lncRNAs) in hepatocellular carcinoma (HCC) remains to be explored. Here, we discovered a novel CT-lncRNA, LINC01977, based on the Genotype-Tissue Expression (GTEx) and The Cancer Genome Atlas (TCGA) databases. LINC01977 was exclusively expressed in testes and highly expressed in HCC. High LINC01977 levels correlated with poorer overall survival (OS) in individuals with HCC. Functional assays showed that LINC01977 promoted HCC growth and metastasis in vitro and in vivo. Mechanistically, LINC01977 directly bound to RBM39 to promote the further entry of Notch2 into the nucleus, thereby preventing the ubiquitination and degradation of Notch2. Furthermore, the RNA binding protein IGF2BP2, one of the m6A modification readers, enhanced the stability of LINC01977, resulting in its high level in HCC. Therefore, the data suggest that LINC01977 interacts with RBM39 and promotes the progression of HCC by inhibiting Notch2 ubiquitination and degradation, indicating that LINC01977 may be a potential biomarker and therapeutic target for HCC patients." @default.
- W4377010967 created "2023-05-19" @default.
- W4377010967 creator A5010407734 @default.
- W4377010967 creator A5014017713 @default.
- W4377010967 creator A5017202894 @default.
- W4377010967 creator A5042261412 @default.
- W4377010967 creator A5042554822 @default.
- W4377010967 creator A5053027346 @default.
- W4377010967 creator A5055640195 @default.
- W4377010967 creator A5062666377 @default.
- W4377010967 creator A5070268771 @default.
- W4377010967 creator A5083670626 @default.
- W4377010967 creator A5088970383 @default.
- W4377010967 creator A5091444661 @default.
- W4377010967 date "2023-05-18" @default.
- W4377010967 modified "2023-10-14" @default.
- W4377010967 title "The cancer-testis lncRNA LINC01977 promotes HCC progression by interacting with RBM39 to prevent Notch2 ubiquitination" @default.
- W4377010967 cites W1985594917 @default.
- W4377010967 cites W2263101679 @default.
- W4377010967 cites W2586407709 @default.
- W4377010967 cites W2771184879 @default.
- W4377010967 cites W2793785833 @default.
- W4377010967 cites W2799466354 @default.
- W4377010967 cites W2888518905 @default.
- W4377010967 cites W2889214328 @default.
- W4377010967 cites W2891701762 @default.
- W4377010967 cites W2896076953 @default.
- W4377010967 cites W2911325539 @default.
- W4377010967 cites W2917612467 @default.
- W4377010967 cites W2956461276 @default.
- W4377010967 cites W2977905919 @default.
- W4377010967 cites W2982088187 @default.
- W4377010967 cites W2997254150 @default.
- W4377010967 cites W3028365961 @default.
- W4377010967 cites W3106930452 @default.
- W4377010967 cites W3128646645 @default.
- W4377010967 cites W3129079068 @default.
- W4377010967 cites W3164912031 @default.
- W4377010967 cites W3189237835 @default.
- W4377010967 cites W3193227997 @default.
- W4377010967 cites W3202882598 @default.
- W4377010967 cites W3205043031 @default.
- W4377010967 cites W3212903603 @default.
- W4377010967 cites W4200441227 @default.
- W4377010967 cites W4205962623 @default.
- W4377010967 cites W4210774372 @default.
- W4377010967 cites W4223575919 @default.
- W4377010967 cites W4225006955 @default.
- W4377010967 cites W4281550551 @default.
- W4377010967 cites W4281571744 @default.
- W4377010967 cites W4281741676 @default.
- W4377010967 cites W4283118324 @default.
- W4377010967 cites W4283826950 @default.
- W4377010967 cites W4283831144 @default.
- W4377010967 cites W4284712161 @default.
- W4377010967 cites W4285394570 @default.
- W4377010967 cites W4285733769 @default.
- W4377010967 cites W4288042207 @default.
- W4377010967 cites W4292079574 @default.
- W4377010967 doi "https://doi.org/10.1038/s41420-023-01459-1" @default.
- W4377010967 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37198207" @default.
- W4377010967 hasPublicationYear "2023" @default.
- W4377010967 type Work @default.
- W4377010967 citedByCount "0" @default.
- W4377010967 crossrefType "journal-article" @default.
- W4377010967 hasAuthorship W4377010967A5010407734 @default.
- W4377010967 hasAuthorship W4377010967A5014017713 @default.
- W4377010967 hasAuthorship W4377010967A5017202894 @default.
- W4377010967 hasAuthorship W4377010967A5042261412 @default.
- W4377010967 hasAuthorship W4377010967A5042554822 @default.
- W4377010967 hasAuthorship W4377010967A5053027346 @default.
- W4377010967 hasAuthorship W4377010967A5055640195 @default.
- W4377010967 hasAuthorship W4377010967A5062666377 @default.
- W4377010967 hasAuthorship W4377010967A5070268771 @default.
- W4377010967 hasAuthorship W4377010967A5083670626 @default.
- W4377010967 hasAuthorship W4377010967A5088970383 @default.
- W4377010967 hasAuthorship W4377010967A5091444661 @default.
- W4377010967 hasBestOaLocation W43770109671 @default.
- W4377010967 hasConcept C104317684 @default.
- W4377010967 hasConcept C121608353 @default.
- W4377010967 hasConcept C25602115 @default.
- W4377010967 hasConcept C2776231280 @default.
- W4377010967 hasConcept C2778019345 @default.
- W4377010967 hasConcept C2779013556 @default.
- W4377010967 hasConcept C2781197716 @default.
- W4377010967 hasConcept C502942594 @default.
- W4377010967 hasConcept C54355233 @default.
- W4377010967 hasConcept C86803240 @default.
- W4377010967 hasConceptScore W4377010967C104317684 @default.
- W4377010967 hasConceptScore W4377010967C121608353 @default.
- W4377010967 hasConceptScore W4377010967C25602115 @default.
- W4377010967 hasConceptScore W4377010967C2776231280 @default.
- W4377010967 hasConceptScore W4377010967C2778019345 @default.
- W4377010967 hasConceptScore W4377010967C2779013556 @default.
- W4377010967 hasConceptScore W4377010967C2781197716 @default.
- W4377010967 hasConceptScore W4377010967C502942594 @default.
- W4377010967 hasConceptScore W4377010967C54355233 @default.
- W4377010967 hasConceptScore W4377010967C86803240 @default.
- W4377010967 hasFunder F4320321001 @default.
- W4377010967 hasIssue "1" @default.