Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377011017> ?p ?o ?g. }
- W4377011017 endingPage "1517" @default.
- W4377011017 startingPage "1503" @default.
- W4377011017 abstract "Objective: Immune responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccines in people with HIV (PWH) with a history of late presentation (LP) and their durability have not been fully characterized. Design: In this prospective, longitudinal study, we sought to assess T-cell and humoral responses to SARS-CoV-2 mRNA vaccination up to 6 months in LP-PWH on effective combination antiretroviral therapy (cART) as compared to HIV-negative healthcare workers (HCWs), and to evaluate whether previous SARS-CoV-2 infection modulates immune responses to vaccine. Methods: SARS-CoV-2 spike (S)-specific T-cell responses were determined by two complementary flow cytometry methodologies, namely activation-induced marker (AIM) assay and intracellular cytokine staining (ICS), whereas humoral responses were measured by ELISA [anti-receptor binding domain (RBD) antibodies) and receptor-binding inhibition assay (spike-ACE2 binding inhibition activity), before vaccination (T0), 1 month (T1) and 5 months (T2) after the second dose. Results: LP-PWH showed at T1 and T2 significant increase of: S-specific memory and circulating T follicular helper (cTfh) CD4 + T cells; polyfunctional Th1-cytokine (IFN-γ, TNF-α, IL-2)- and Th2-cytokine (IL-4)-producing S-specific CD4 + T cells; anti-RBD antibodies and spike-ACE2 binding inhibition activity. Immune responses to vaccine in LP-PWH were not inferior to HCWs overall, yet S-specific CD8 + T cells and spike-ACE2 binding inhibition activity correlated negatively with markers of immune recovery on cART. Interestingly, natural SARS-CoV-2 infection, while able to sustain S-specific antibody response, seems less efficacious in inducing a T-cell memory and in boosting immune responses to vaccine, possibly reflecting an enduring partial immunodeficiency. Conclusions: Altogether, these findings support the need for additional vaccine doses in PWH with a history of advanced immune depression and poor immune recovery on effective cART." @default.
- W4377011017 created "2023-05-19" @default.
- W4377011017 creator A5031123880 @default.
- W4377011017 creator A5036960337 @default.
- W4377011017 creator A5072109714 @default.
- W4377011017 creator A5076739061 @default.
- W4377011017 creator A5077561765 @default.
- W4377011017 creator A5078701955 @default.
- W4377011017 date "2023-05-18" @default.
- W4377011017 modified "2023-10-17" @default.
- W4377011017 title "Six-month immune responses to mRNA-1273 vaccine in combination antiretroviral therapy treated late presenter people with HIV according to previous SARS-CoV-2 infection" @default.
- W4377011017 cites W1498719741 @default.
- W4377011017 cites W1977775509 @default.
- W4377011017 cites W1987375408 @default.
- W4377011017 cites W1992480011 @default.
- W4377011017 cites W2003411924 @default.
- W4377011017 cites W2005263803 @default.
- W4377011017 cites W2033665909 @default.
- W4377011017 cites W2035383124 @default.
- W4377011017 cites W2042987550 @default.
- W4377011017 cites W2046851673 @default.
- W4377011017 cites W2049614028 @default.
- W4377011017 cites W2066738380 @default.
- W4377011017 cites W2077353725 @default.
- W4377011017 cites W2106164053 @default.
- W4377011017 cites W2123863181 @default.
- W4377011017 cites W2134361139 @default.
- W4377011017 cites W2140827773 @default.
- W4377011017 cites W2141264905 @default.
- W4377011017 cites W2144361427 @default.
- W4377011017 cites W2149387162 @default.
- W4377011017 cites W2317525145 @default.
- W4377011017 cites W2560755407 @default.
- W4377011017 cites W2567350736 @default.
- W4377011017 cites W2765584638 @default.
- W4377011017 cites W2768038187 @default.
- W4377011017 cites W2774699266 @default.
- W4377011017 cites W2972334025 @default.
- W4377011017 cites W2998394393 @default.
- W4377011017 cites W3001393750 @default.
- W4377011017 cites W3037624367 @default.
- W4377011017 cites W3043722389 @default.
- W4377011017 cites W3044482768 @default.
- W4377011017 cites W3048765898 @default.
- W4377011017 cites W3048856381 @default.
- W4377011017 cites W3049250654 @default.
- W4377011017 cites W3090717270 @default.
- W4377011017 cites W3090844627 @default.
- W4377011017 cites W3107730772 @default.
- W4377011017 cites W3108193091 @default.
- W4377011017 cites W3118375381 @default.
- W4377011017 cites W3119858919 @default.
- W4377011017 cites W3123967880 @default.
- W4377011017 cites W3126498743 @default.
- W4377011017 cites W3126521809 @default.
- W4377011017 cites W3128190569 @default.
- W4377011017 cites W3143857974 @default.
- W4377011017 cites W3157063593 @default.
- W4377011017 cites W3157493555 @default.
- W4377011017 cites W3163347061 @default.
- W4377011017 cites W3163594895 @default.
- W4377011017 cites W3164002264 @default.
- W4377011017 cites W3165367963 @default.
- W4377011017 cites W3165773854 @default.
- W4377011017 cites W3183662884 @default.
- W4377011017 cites W3193980389 @default.
- W4377011017 cites W3196397911 @default.
- W4377011017 cites W3196516725 @default.
- W4377011017 cites W3197127917 @default.
- W4377011017 cites W3198862438 @default.
- W4377011017 cites W3200071174 @default.
- W4377011017 cites W3203346460 @default.
- W4377011017 cites W3206370075 @default.
- W4377011017 cites W3210318430 @default.
- W4377011017 cites W3214763108 @default.
- W4377011017 cites W3215706785 @default.
- W4377011017 cites W4200068356 @default.
- W4377011017 cites W4200430875 @default.
- W4377011017 cites W4200498553 @default.
- W4377011017 cites W4206542106 @default.
- W4377011017 cites W4207066590 @default.
- W4377011017 cites W4210317504 @default.
- W4377011017 cites W4210365826 @default.
- W4377011017 cites W4210792795 @default.
- W4377011017 cites W4214871180 @default.
- W4377011017 cites W4220886379 @default.
- W4377011017 cites W4223990185 @default.
- W4377011017 cites W4224627793 @default.
- W4377011017 cites W4225011156 @default.
- W4377011017 cites W4225880170 @default.
- W4377011017 cites W4226208081 @default.
- W4377011017 cites W4226281116 @default.
- W4377011017 cites W4229067863 @default.
- W4377011017 cites W4234769079 @default.
- W4377011017 cites W4280530640 @default.
- W4377011017 cites W4281687206 @default.
- W4377011017 cites W4281730444 @default.
- W4377011017 cites W4281777868 @default.