FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377011024> ?p ?o ?g. }

• W4377011024 abstract "Blood serum is arguably the most analyzed biofluid for disease prediction and diagnosis. Herein, we benchmarked five different serum abundant protein depletion (SAPD) kits with regard to the identification of disease-specific biomarkers in human serum using bottom-up proteomics. As expected, the IgG removal efficiency among the SAPD kits is highly variable, ranging from 70% to 93%. A pairwise comparison of database search results showed a 10%-19% variation in protein identification among the kits. Immunocapturing-based SAPD kits against IgG and albumin outperformed the others in the removal of these two abundant proteins. Conversely, non-antibody-based methods (i.e., kits using ion exchange resins) and kits leveraging a multi-antibody approach were proven to be less efficient in depleting IgG/albumin from samples but led to the highest number of identified peptides. Notably, our results indicate that different cancer biomarkers could be enriched up to 10% depending on the utilized SAPD kit compared with the undepleted sample. Additionally, functional analysis of the bottom-up proteomic results revealed that different SAPD kits enrich distinct disease- and pathway-specific protein sets. Overall, our study emphasizes that a careful selection of the appropriate commercial SAPD kit is crucial for the analysis of disease biomarkers in serum by shotgun proteomics." @default.
• W4377011024 created "2023-05-19" @default.
• W4377011024 creator A5001477677 @default.
• W4377011024 creator A5015085792 @default.
• W4377011024 creator A5032570621 @default.
• W4377011024 creator A5035195284 @default.
• W4377011024 creator A5047362882 @default.
• W4377011024 creator A5056675012 @default.
• W4377011024 creator A5056912647 @default.
• W4377011024 creator A5069095946 @default.
• W4377011024 creator A5076894751 @default.
• W4377011024 creator A5077414271 @default.
• W4377011024 creator A5091094466 @default.
• W4377011024 date "2023-05-18" @default.
• W4377011024 modified "2023-10-18" @default.
• W4377011024 title "Proteomics evaluation of five economical commercial abundant protein depletion kits for enrichment of diseases‐specific biomarkers from blood serum" @default.
• W4377011024 cites W1560020441 @default.
• W4377011024 cites W1796504791 @default.
• W4377011024 cites W1975304761 @default.
• W4377011024 cites W1976531401 @default.
• W4377011024 cites W2021230254 @default.
• W4377011024 cites W2036944307 @default.
• W4377011024 cites W2084373725 @default.
• W4377011024 cites W2092956762 @default.
• W4377011024 cites W2109326791 @default.
• W4377011024 cites W2138745251 @default.
• W4377011024 cites W215936125 @default.
• W4377011024 cites W2160061958 @default.
• W4377011024 cites W2302629258 @default.
• W4377011024 cites W2599830752 @default.
• W4377011024 cites W2624751329 @default.
• W4377011024 cites W2707568461 @default.
• W4377011024 cites W2750686414 @default.
• W4377011024 cites W2767195935 @default.
• W4377011024 cites W2768301549 @default.
• W4377011024 cites W2794961243 @default.
• W4377011024 cites W2889809820 @default.
• W4377011024 cites W2946202802 @default.
• W4377011024 cites W2980443869 @default.
• W4377011024 cites W2997022986 @default.
• W4377011024 cites W2998913628 @default.
• W4377011024 cites W3089427657 @default.
• W4377011024 cites W3145969289 @default.
• W4377011024 cites W3183849791 @default.
• W4377011024 cites W3204471759 @default.
• W4377011024 cites W3207607557 @default.
• W4377011024 cites W4212767545 @default.
• W4377011024 cites W4226382744 @default.
• W4377011024 cites W4289593505 @default.
• W4377011024 doi "https://doi.org/10.1002/pmic.202300150" @default.
• W4377011024 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37199141" @default.
• W4377011024 hasPublicationYear "2023" @default.
• W4377011024 type Work @default.
• W4377011024 citedByCount "2" @default.
• W4377011024 countsByYear W43770110242023 @default.
• W4377011024 crossrefType "journal-article" @default.
• W4377011024 hasAuthorship W4377011024A5001477677 @default.
• W4377011024 hasAuthorship W4377011024A5015085792 @default.
• W4377011024 hasAuthorship W4377011024A5032570621 @default.
• W4377011024 hasAuthorship W4377011024A5035195284 @default.
• W4377011024 hasAuthorship W4377011024A5047362882 @default.
• W4377011024 hasAuthorship W4377011024A5056675012 @default.
• W4377011024 hasAuthorship W4377011024A5056912647 @default.
• W4377011024 hasAuthorship W4377011024A5069095946 @default.
• W4377011024 hasAuthorship W4377011024A5076894751 @default.
• W4377011024 hasAuthorship W4377011024A5077414271 @default.
• W4377011024 hasAuthorship W4377011024A5091094466 @default.
• W4377011024 hasConcept C104317684 @default.
• W4377011024 hasConcept C146543888 @default.
• W4377011024 hasConcept C2776125364 @default.
• W4377011024 hasConcept C46111723 @default.
• W4377011024 hasConcept C55493867 @default.
• W4377011024 hasConcept C70721500 @default.
• W4377011024 hasConcept C86803240 @default.
• W4377011024 hasConceptScore W4377011024C104317684 @default.
• W4377011024 hasConceptScore W4377011024C146543888 @default.
• W4377011024 hasConceptScore W4377011024C2776125364 @default.
• W4377011024 hasConceptScore W4377011024C46111723 @default.
• W4377011024 hasConceptScore W4377011024C55493867 @default.
• W4377011024 hasConceptScore W4377011024C70721500 @default.
• W4377011024 hasConceptScore W4377011024C86803240 @default.
• W4377011024 hasFunder F4320306076 @default.
• W4377011024 hasIssue "20" @default.
• W4377011024 hasLocation W43770110241 @default.
• W4377011024 hasLocation W43770110242 @default.
• W4377011024 hasOpenAccess W4377011024 @default.
• W4377011024 hasPrimaryLocation W43770110241 @default.
• W4377011024 hasRelatedWork W1990804418 @default.
• W4377011024 hasRelatedWork W2026471944 @default.
• W4377011024 hasRelatedWork W2039782763 @default.
• W4377011024 hasRelatedWork W2082860237 @default.
• W4377011024 hasRelatedWork W2088324202 @default.
• W4377011024 hasRelatedWork W2123607946 @default.
• W4377011024 hasRelatedWork W2130076355 @default.
• W4377011024 hasRelatedWork W2168014260 @default.
• W4377011024 hasRelatedWork W2590273458 @default.
• W4377011024 hasRelatedWork W4321496444 @default.
• W4377011024 hasVolume "23" @default.
• W4377011024 isParatext "false" @default.
• W4377011024 isRetracted "false" @default.

• next