FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377011042> ?p ?o ?g. }

• W4377011042 abstract "Pancreatic adenocarcinoma (PDAC) is a malignant tumor with high heterogeneity and poor prognosis. In this study, we sought to identify the value of platelet-related genes in prognosis and heterogeneity of PDAC through multiple transcriptomic methods.Based on datasets from Gene Expression Omnibus and The Cancer Genome Atlas (TCGA), platelet-related genes were screened out, and the TCGA cohort (n = 171) was identified into two subtypes by unsupervised clustering. The platelet-related risk score model (PLRScore) was constructed by univariate Cox and LASSO regression, and the predictive ability was evaluated by Kaplan-Meier test and time-dependent receiver operating characteristic (ROC) curves. The results were validated in two other external validation sets, ICGC-CA (n = 140) and GSE62452 (n = 66). Furthermore, predictive nomogram containing clinical characteristics and PLRScore was established. In addition, we determined the possible correlation between PLRScore and immune infiltration and response of immunotherapy. Finally, we analyzed the heterogeneity of our signature in various types of cells using single-cell analysis.Platelet-related subtypes that have significant difference of overall survival and immune states (p < 0.05) were identified. PLRScore model based on four-gene signature (CEP55, LAMA3, CA12, SCN8A) was constructed to predict patient prognosis. The AUCs of training cohort were 0.697, 0.687 and 0.675 for 1-, 3-and 5-year, respectively. Further evaluation of the validation cohorts yielded similar results. In addition, PLRScore was associated with immune cell infiltration and immune checkpoint expression, and had promising ability to predict response to immunotherapy of PDAC.In this study, the platelet-related subtypes were identified and the four-gene signature was constructed and validated. It may provide new insights into the therapeutic decision-making and molecular targets of PDAC." @default.
• W4377011042 created "2023-05-19" @default.
• W4377011042 creator A5014898916 @default.
• W4377011042 creator A5023990339 @default.
• W4377011042 creator A5027799457 @default.
• W4377011042 creator A5030064573 @default.
• W4377011042 creator A5071949165 @default.
• W4377011042 creator A5086379907 @default.
• W4377011042 date "2023-05-17" @default.
• W4377011042 modified "2023-10-18" @default.
• W4377011042 title "Revealing platelet-related subtypes and prognostic signature in pancreatic adenocarcinoma" @default.
• W4377011042 cites W1497915798 @default.
• W4377011042 cites W2068323997 @default.
• W4377011042 cites W2154790710 @default.
• W4377011042 cites W2285093314 @default.
• W4377011042 cites W2526864176 @default.
• W4377011042 cites W2765354611 @default.
• W4377011042 cites W2797421660 @default.
• W4377011042 cites W2885041076 @default.
• W4377011042 cites W2886911223 @default.
• W4377011042 cites W2889158000 @default.
• W4377011042 cites W2897062681 @default.
• W4377011042 cites W2902616740 @default.
• W4377011042 cites W2906679447 @default.
• W4377011042 cites W2908022661 @default.
• W4377011042 cites W2953461318 @default.
• W4377011042 cites W2954610188 @default.
• W4377011042 cites W2974877234 @default.
• W4377011042 cites W2986660272 @default.
• W4377011042 cites W3014701180 @default.
• W4377011042 cites W3090066168 @default.
• W4377011042 cites W3092470635 @default.
• W4377011042 cites W3093509760 @default.
• W4377011042 cites W3095648730 @default.
• W4377011042 cites W3096660036 @default.
• W4377011042 cites W3102267442 @default.
• W4377011042 cites W3115967860 @default.
• W4377011042 cites W3128646645 @default.
• W4377011042 cites W3128711231 @default.
• W4377011042 cites W3136067782 @default.
• W4377011042 cites W3140194877 @default.
• W4377011042 cites W3188466296 @default.
• W4377011042 cites W3194709831 @default.
• W4377011042 cites W3210812732 @default.
• W4377011042 cites W3215774169 @default.
• W4377011042 cites W4223592909 @default.
• W4377011042 cites W792445861 @default.
• W4377011042 doi "https://doi.org/10.1186/s12920-023-01530-x" @default.
• W4377011042 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37198621" @default.
• W4377011042 hasPublicationYear "2023" @default.
• W4377011042 type Work @default.
• W4377011042 citedByCount "0" @default.
• W4377011042 crossrefType "journal-article" @default.
• W4377011042 hasAuthorship W4377011042A5014898916 @default.
• W4377011042 hasAuthorship W4377011042A5023990339 @default.
• W4377011042 hasAuthorship W4377011042A5027799457 @default.
• W4377011042 hasAuthorship W4377011042A5030064573 @default.
• W4377011042 hasAuthorship W4377011042A5071949165 @default.
• W4377011042 hasAuthorship W4377011042A5086379907 @default.
• W4377011042 hasBestOaLocation W43770110421 @default.
• W4377011042 hasConcept C104317684 @default.
• W4377011042 hasConcept C121608353 @default.
• W4377011042 hasConcept C126322002 @default.
• W4377011042 hasConcept C143998085 @default.
• W4377011042 hasConcept C150194340 @default.
• W4377011042 hasConcept C203014093 @default.
• W4377011042 hasConcept C2777701055 @default.
• W4377011042 hasConcept C2779733811 @default.
• W4377011042 hasConcept C2780210213 @default.
• W4377011042 hasConcept C2781182431 @default.
• W4377011042 hasConcept C34626388 @default.
• W4377011042 hasConcept C50382708 @default.
• W4377011042 hasConcept C54355233 @default.
• W4377011042 hasConcept C58471807 @default.
• W4377011042 hasConcept C71924100 @default.
• W4377011042 hasConcept C86803240 @default.
• W4377011042 hasConcept C8891405 @default.
• W4377011042 hasConceptScore W4377011042C104317684 @default.
• W4377011042 hasConceptScore W4377011042C121608353 @default.
• W4377011042 hasConceptScore W4377011042C126322002 @default.
• W4377011042 hasConceptScore W4377011042C143998085 @default.
• W4377011042 hasConceptScore W4377011042C150194340 @default.
• W4377011042 hasConceptScore W4377011042C203014093 @default.
• W4377011042 hasConceptScore W4377011042C2777701055 @default.
• W4377011042 hasConceptScore W4377011042C2779733811 @default.
• W4377011042 hasConceptScore W4377011042C2780210213 @default.
• W4377011042 hasConceptScore W4377011042C2781182431 @default.
• W4377011042 hasConceptScore W4377011042C34626388 @default.
• W4377011042 hasConceptScore W4377011042C50382708 @default.
• W4377011042 hasConceptScore W4377011042C54355233 @default.
• W4377011042 hasConceptScore W4377011042C58471807 @default.
• W4377011042 hasConceptScore W4377011042C71924100 @default.
• W4377011042 hasConceptScore W4377011042C86803240 @default.
• W4377011042 hasConceptScore W4377011042C8891405 @default.
• W4377011042 hasFunder F4320321001 @default.
• W4377011042 hasIssue "1" @default.
• W4377011042 hasLocation W43770110421 @default.
• W4377011042 hasLocation W43770110422 @default.
• W4377011042 hasOpenAccess W4377011042 @default.
• W4377011042 hasPrimaryLocation W43770110421 @default.

• next