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- W4377011103 abstract "Background: Considering the role of visfatin in nonalcoholic fatty liver disease (NAFLD), a growing global epidemic, this article explores the potential association between the visfatin gene ( NAMPT) and NAFLD. Methods: We used the PCR-restriction fragment length polymorphism method to genotype the rs1319501 promoter variant of the NAMPT gene in 154 patients with biopsy-proven NAFLD and 158 controls in this case–control genetic association study. Results: The ‘CC+TC’ genotype of NAMPT rs1319501 in comparison to the ‘TT’ genotype occurred less frequently in the cases with NAFLD than the controls, and the difference remained significant after adjustment for confounding factors (p = 0.029; odds ratio = 0.55; 95% CI = 0.31–0.82). Conclusion: This study showed, for the first time, that the carriers of the NAMPT rs1319501 ‘CC+TC’ genotype had a 45% decreased risk for NAFLD." @default.
- W4377011103 created "2023-05-19" @default.
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- W4377011103 date "2023-05-18" @default.
- W4377011103 modified "2023-09-30" @default.
- W4377011103 title "A visfatin gene promoter polymorphism (rs1319501) is associated with susceptibility to nonalcoholic fatty liver disease" @default.
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- W4377011103 doi "https://doi.org/10.2217/pme-2022-0100" @default.
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- W4377011103 hasPublicationYear "2023" @default.
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