Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377011142> ?p ?o ?g. }
- W4377011142 endingPage "1721" @default.
- W4377011142 startingPage "1713" @default.
- W4377011142 abstract "Realgar-Indigo naturalis formula (RIF), with A4S4 as a major ingredient, is an oral arsenic used in China to treat pediatric acute promyelocytic leukemia (APL). The efficacy of RIF is similar to that of arsenic trioxide (ATO). However, the effects of these two arsenicals on differentiation syndrome (DS) and coagulation disorders, the two main life-threatening events in children with APL, remain unclear. We retrospectively analyzed 68 consecutive children with APL from South China Children Leukemia Group-APL (SCCLG-APL) study. Patients received all-trans retinoic acid (ATRA) on day 1 of induction therapy. ATO 0.16 mg/kg day or RIF 135 mg/kg·day was administrated on day 5, while mitoxantrone was administered on day 3 (non-high-risk) or days 2-4 (high-risk). The incidences of DS were 3.0% and 5.7% in ATO (n = 33) and RIF (n = 35) arms (p = 0.590), and 10.3% and 0% in patients with and without differentiation-related hyperleukocytosis (p = 0.04), respectively. Moreover, in patients with differentiation-related hyperleukocytosis, the incidence of DS was not significantly different between ATO and RIF arms. The dynamic changes of leukocyte count between arms were not statistically different. However, patients with leukocyte count > 2.61 × 109/L or percentage of promyelocytes in peripheral blood > 26.5% tended to develop hyperleukocytosis. The improvement of coagulation indexes in ATO and RIF arms was similar, with fibrinogen and prothrombin time having the quickest recovery rate. This study showed that the incidence of DS and recovery of coagulopathy are similar when treating pediatric APL with RIF or ATO." @default.
- W4377011142 created "2023-05-19" @default.
- W4377011142 creator A5001007969 @default.
- W4377011142 creator A5005036619 @default.
- W4377011142 creator A5008105553 @default.
- W4377011142 creator A5016710816 @default.
- W4377011142 creator A5028207115 @default.
- W4377011142 creator A5041822883 @default.
- W4377011142 creator A5047405965 @default.
- W4377011142 creator A5054228072 @default.
- W4377011142 creator A5056165846 @default.
- W4377011142 creator A5058417243 @default.
- W4377011142 creator A5080133933 @default.
- W4377011142 creator A5087495260 @default.
- W4377011142 creator A5089317577 @default.
- W4377011142 creator A5091970958 @default.
- W4377011142 date "2023-05-18" @default.
- W4377011142 modified "2023-09-30" @default.
- W4377011142 title "Differentiation syndrome and coagulation disorder — comparison between treatment with oral and intravenous arsenics in pediatric acute promyelocytic leukemia" @default.
- W4377011142 cites W1522335697 @default.
- W4377011142 cites W1622548798 @default.
- W4377011142 cites W192794212 @default.
- W4377011142 cites W2014248371 @default.
- W4377011142 cites W2043306142 @default.
- W4377011142 cites W2071479387 @default.
- W4377011142 cites W2129338773 @default.
- W4377011142 cites W2169503443 @default.
- W4377011142 cites W2326597359 @default.
- W4377011142 cites W2474389367 @default.
- W4377011142 cites W2557900563 @default.
- W4377011142 cites W2559463313 @default.
- W4377011142 cites W2580773282 @default.
- W4377011142 cites W2739607402 @default.
- W4377011142 cites W2756049676 @default.
- W4377011142 cites W2769006419 @default.
- W4377011142 cites W2803060244 @default.
- W4377011142 cites W2806255063 @default.
- W4377011142 cites W2806637980 @default.
- W4377011142 cites W2889022305 @default.
- W4377011142 cites W3165220706 @default.
- W4377011142 cites W4213142659 @default.
- W4377011142 cites W4283591534 @default.
- W4377011142 doi "https://doi.org/10.1007/s00277-023-05270-x" @default.
- W4377011142 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37199788" @default.
- W4377011142 hasPublicationYear "2023" @default.
- W4377011142 type Work @default.
- W4377011142 citedByCount "0" @default.
- W4377011142 crossrefType "journal-article" @default.
- W4377011142 hasAuthorship W4377011142A5001007969 @default.
- W4377011142 hasAuthorship W4377011142A5005036619 @default.
- W4377011142 hasAuthorship W4377011142A5008105553 @default.
- W4377011142 hasAuthorship W4377011142A5016710816 @default.
- W4377011142 hasAuthorship W4377011142A5028207115 @default.
- W4377011142 hasAuthorship W4377011142A5041822883 @default.
- W4377011142 hasAuthorship W4377011142A5047405965 @default.
- W4377011142 hasAuthorship W4377011142A5054228072 @default.
- W4377011142 hasAuthorship W4377011142A5056165846 @default.
- W4377011142 hasAuthorship W4377011142A5058417243 @default.
- W4377011142 hasAuthorship W4377011142A5080133933 @default.
- W4377011142 hasAuthorship W4377011142A5087495260 @default.
- W4377011142 hasAuthorship W4377011142A5089317577 @default.
- W4377011142 hasAuthorship W4377011142A5091970958 @default.
- W4377011142 hasBestOaLocation W43770111421 @default.
- W4377011142 hasConcept C104317684 @default.
- W4377011142 hasConcept C120665830 @default.
- W4377011142 hasConcept C121332964 @default.
- W4377011142 hasConcept C126322002 @default.
- W4377011142 hasConcept C185592680 @default.
- W4377011142 hasConcept C190283241 @default.
- W4377011142 hasConcept C2776601000 @default.
- W4377011142 hasConcept C2778461978 @default.
- W4377011142 hasConcept C2778734968 @default.
- W4377011142 hasConcept C2779036427 @default.
- W4377011142 hasConcept C2779936836 @default.
- W4377011142 hasConcept C2780386689 @default.
- W4377011142 hasConcept C2780434524 @default.
- W4377011142 hasConcept C2781121885 @default.
- W4377011142 hasConcept C55493867 @default.
- W4377011142 hasConcept C61511704 @default.
- W4377011142 hasConcept C71924100 @default.
- W4377011142 hasConcept C90924648 @default.
- W4377011142 hasConceptScore W4377011142C104317684 @default.
- W4377011142 hasConceptScore W4377011142C120665830 @default.
- W4377011142 hasConceptScore W4377011142C121332964 @default.
- W4377011142 hasConceptScore W4377011142C126322002 @default.
- W4377011142 hasConceptScore W4377011142C185592680 @default.
- W4377011142 hasConceptScore W4377011142C190283241 @default.
- W4377011142 hasConceptScore W4377011142C2776601000 @default.
- W4377011142 hasConceptScore W4377011142C2778461978 @default.
- W4377011142 hasConceptScore W4377011142C2778734968 @default.
- W4377011142 hasConceptScore W4377011142C2779036427 @default.
- W4377011142 hasConceptScore W4377011142C2779936836 @default.
- W4377011142 hasConceptScore W4377011142C2780386689 @default.
- W4377011142 hasConceptScore W4377011142C2780434524 @default.
- W4377011142 hasConceptScore W4377011142C2781121885 @default.
- W4377011142 hasConceptScore W4377011142C55493867 @default.
- W4377011142 hasConceptScore W4377011142C61511704 @default.
- W4377011142 hasConceptScore W4377011142C71924100 @default.