Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377011181> ?p ?o ?g. }
- W4377011181 abstract "The mechanistic regulation of bone mass in aged animals is poorly understood. In this study, we examined the role of SIRT6, a longevity-associated factor, in osteocytes, using mice lacking Sirt6 in Dmp-1-expressing cells (cKO mice) and the MLO-Y4 osteocyte-like cell line. cKO mice exhibited increased osteocytic expression of Sost, Fgf23 and senescence inducing gene Pai-1 and the senescence markers p16 and Il-6, decreased serum phosphate levels, and low-turnover osteopenia. The cKO phenotype was reversed in mice that were a cross of PAI-1-null mice with cKO mice. Furthermore, senescence induction in MLO-Y4 cells increased the Fgf23 and Sost mRNA expression. Sirt6 knockout and senescence induction increased HIF-1α binding to the Fgf23 enhancer sequence. Bone mass and serum phosphate levels were higher in PAI-1-null aged mice than in wild-type mice. Therefore, SIRT6 agonists or PAI-1 inhibitors may be promising therapeutic options for aging-related bone metabolism disruptions." @default.
- W4377011181 created "2023-05-19" @default.
- W4377011181 creator A5002256460 @default.
- W4377011181 creator A5013297039 @default.
- W4377011181 creator A5030396786 @default.
- W4377011181 creator A5034273023 @default.
- W4377011181 creator A5036703700 @default.
- W4377011181 creator A5074030558 @default.
- W4377011181 creator A5074451747 @default.
- W4377011181 creator A5088257679 @default.
- W4377011181 date "2023-05-17" @default.
- W4377011181 modified "2023-09-29" @default.
- W4377011181 title "SIRT6-PAI-1 axis is a promising therapeutic target in aging-related bone metabolic disruption" @default.
- W4377011181 cites W1471514516 @default.
- W4377011181 cites W1486387963 @default.
- W4377011181 cites W1543384246 @default.
- W4377011181 cites W1934874004 @default.
- W4377011181 cites W1970100915 @default.
- W4377011181 cites W1978047251 @default.
- W4377011181 cites W1978888457 @default.
- W4377011181 cites W2001720505 @default.
- W4377011181 cites W2003457351 @default.
- W4377011181 cites W2007478852 @default.
- W4377011181 cites W2007928508 @default.
- W4377011181 cites W2008314623 @default.
- W4377011181 cites W2019548769 @default.
- W4377011181 cites W2029969982 @default.
- W4377011181 cites W2031108531 @default.
- W4377011181 cites W2039378889 @default.
- W4377011181 cites W2039619137 @default.
- W4377011181 cites W2042716686 @default.
- W4377011181 cites W2054756476 @default.
- W4377011181 cites W2056059734 @default.
- W4377011181 cites W2056495027 @default.
- W4377011181 cites W2061684338 @default.
- W4377011181 cites W2061912303 @default.
- W4377011181 cites W2063084036 @default.
- W4377011181 cites W2075034834 @default.
- W4377011181 cites W2080290533 @default.
- W4377011181 cites W2080339543 @default.
- W4377011181 cites W2080518240 @default.
- W4377011181 cites W2083288593 @default.
- W4377011181 cites W2087378917 @default.
- W4377011181 cites W2091451179 @default.
- W4377011181 cites W2108887402 @default.
- W4377011181 cites W2109560454 @default.
- W4377011181 cites W2111614529 @default.
- W4377011181 cites W2119934014 @default.
- W4377011181 cites W2123927456 @default.
- W4377011181 cites W2135671879 @default.
- W4377011181 cites W2143389186 @default.
- W4377011181 cites W2151609557 @default.
- W4377011181 cites W2152075068 @default.
- W4377011181 cites W2167572811 @default.
- W4377011181 cites W2171748049 @default.
- W4377011181 cites W2255940584 @default.
- W4377011181 cites W2400688846 @default.
- W4377011181 cites W2479889183 @default.
- W4377011181 cites W2534651070 @default.
- W4377011181 cites W2544998112 @default.
- W4377011181 cites W2546015443 @default.
- W4377011181 cites W2560341155 @default.
- W4377011181 cites W2750509325 @default.
- W4377011181 cites W2755090653 @default.
- W4377011181 cites W2757913872 @default.
- W4377011181 cites W2766078678 @default.
- W4377011181 cites W2768485358 @default.
- W4377011181 cites W2769338565 @default.
- W4377011181 cites W2772373988 @default.
- W4377011181 cites W2807145926 @default.
- W4377011181 cites W2936423264 @default.
- W4377011181 cites W2952344082 @default.
- W4377011181 cites W2972868570 @default.
- W4377011181 cites W2984194295 @default.
- W4377011181 cites W3037052478 @default.
- W4377011181 cites W4213158348 @default.
- W4377011181 cites W2791521959 @default.
- W4377011181 cites W2950318190 @default.
- W4377011181 doi "https://doi.org/10.1038/s41598-023-33297-7" @default.
- W4377011181 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37198221" @default.
- W4377011181 hasPublicationYear "2023" @default.
- W4377011181 type Work @default.
- W4377011181 citedByCount "0" @default.
- W4377011181 crossrefType "journal-article" @default.
- W4377011181 hasAuthorship W4377011181A5002256460 @default.
- W4377011181 hasAuthorship W4377011181A5013297039 @default.
- W4377011181 hasAuthorship W4377011181A5030396786 @default.
- W4377011181 hasAuthorship W4377011181A5034273023 @default.
- W4377011181 hasAuthorship W4377011181A5036703700 @default.
- W4377011181 hasAuthorship W4377011181A5074030558 @default.
- W4377011181 hasAuthorship W4377011181A5074451747 @default.
- W4377011181 hasAuthorship W4377011181A5088257679 @default.
- W4377011181 hasBestOaLocation W43770111811 @default.
- W4377011181 hasConcept C104317684 @default.
- W4377011181 hasConcept C119157956 @default.
- W4377011181 hasConcept C126322002 @default.
- W4377011181 hasConcept C134018914 @default.
- W4377011181 hasConcept C170033053 @default.
- W4377011181 hasConcept C182704531 @default.
- W4377011181 hasConcept C202751555 @default.