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• W4377011211 abstract "Abstract WHO guidelines recommend daily oral tenofovir disoproxil fumarate (TDF) and emtricitabine (FTC) for pre‐exposure prophylaxis (PrEP) of HIV in people at high risk of HIV infection. However, due to social, psychological and other reasons, the compliance with daily oral TDF‐FTC in real life is low. Long‐acting cabotegravir is currently the only long‐acting drug approved by the U.S. Food and Drug Administration (FDA) for HIV PrEP. Due to the long dosing interval (8 weeks), long‐acting cabotegravir has low compliance requirements for people at high risk of HIV infection. We aimed to discuss the feasibility of long‐acting cabotegravir to replace TDF‐FTC as HIV PrEP based on efficacy and safety analyses. Randomized controlled trials were retrieved, and R software was used for meta‐analysis after data extraction. and discussion: Results of the meta‐analysis showed that compared with TDF‐FTC, long‐acting cabotegravir was associated with a lower risk of HIV infection (HR = 0.22, 95% CI: 0.08–0.59, p < 0.01), less decreased creatinine clearance (RR = 0.96, 95% CI: 0.93–0.99, p < 0.01), but more tolerated injection sites adverse events ( p < 0.01). No statistically significant differences were found between long‐acting cabotegravir and oral placebo in non‐injection‐related adverse events (creatine phosphokinase, headache, nasopharyngitis, upper respiratory tract infection and gastroenteritis) ( p > 0.05). Long‐acting cabotegravir has a manageable safety profile and is more effective than TDF‐FTC in preventing HIV infection. Interestingly, decreased creatinine clearance occurred less frequently with long‐acting cabotegravir than with TDF‐FTC. Long‐acting cabotegravir is very promising to replace TDF‐TFC in the future, which requires more large‐sample, high‐quality RCTs to verify." @default.
• W4377011211 created "2023-05-19" @default.
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• W4377011211 date "2023-05-17" @default.
• W4377011211 modified "2023-10-17" @default.
• W4377011211 title "Efficacy and safety of long‐acting cabotegravir versus oral tenofovir disoproxil fumarate‐emtricitabine as HIV pre‐exposure prophylaxis: A systematic review and meta‐analysis" @default.
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• W4377011211 doi "https://doi.org/10.1002/rmv.2460" @default.
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