FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377011217> ?p ?o ?g. }

• W4377011217 endingPage "566" @default.
• W4377011217 startingPage "553" @default.
• W4377011217 abstract "Asthma is a chronic heterogeneous respiratory disease resulting from a complex interplay between genetic variations and environmental exposures. There are sex disparities in the prevalence and severity of asthma in males and females. Asthma prevalence is higher in males during childhood but increases in females in adulthood. The mechanisms underlying these sex differences are not well understood; nevertheless, genetic variations, hormonal changes, and environmental influences are thought to play important roles. This study aimed to identify sex-specific genetic variants associated with asthma using CLSA genomic and questionnaire data.First, we conducted a genome-wide SNP-by-sex interaction analysis on 23,323 individuals, examining 416,562 single nucleotide polymorphisms (SNPs) after quality control, followed by sex-stratified survey logistic regression of SNPs with interaction p-value less than 10¯5.Out of the 49 SNPs with interaction p-value less than 10-5, a sex-stratified survey logistic regression showed that five male-specific SNPs (rs6701638, rs17071077, rs254804, rs6013213, and rs2968822) in/near KIF26B, NMBR, PEPD, RTN4, and NFATC2 loci, and three female-specific SNPs (rs2968801, rs2864052, and rs9525931) in/near RTN4, and SERP2 loci were significantly associated with asthma after Bonferroni correction. An SNP (rs36213) in the EPHB1 gene was significantly associated with an increased risk of asthma in males [OR=1.35, 95% CI (1.14, 1.60)] but with a reduced risk of asthma in females [OR=0.84, 95% CI (0.76, 0.92)] after Bonferroni correction.We discovered novel sex-specific genetic markers in/near the KIF26B, RTN4, EPHB1, NMBR, SERP2, PEPD, and NFATC2 genes that could potentially shed light on the sex differences in asthma susceptibility in males and females. Future mechanistic studies are required to understand better the underlying sex-related pathways of the identified loci in asthma development." @default.
• W4377011217 created "2023-05-19" @default.
• W4377011217 creator A5054859305 @default.
• W4377011217 creator A5067822778 @default.
• W4377011217 creator A5067895480 @default.
• W4377011217 creator A5079311452 @default.
• W4377011217 date "2023-05-01" @default.
• W4377011217 modified "2023-10-14" @default.
• W4377011217 title "Identification of Sex-Specific Genetic Polymorphisms Associated with Asthma in Middle-Aged and Older Canadian Adults: An Analysis of CLSA Data" @default.
• W4377011217 cites W1488607683 @default.
• W4377011217 cites W1801147112 @default.
• W4377011217 cites W1967860167 @default.
• W4377011217 cites W1969401509 @default.
• W4377011217 cites W1969966409 @default.
• W4377011217 cites W1969972415 @default.
• W4377011217 cites W1971160226 @default.
• W4377011217 cites W1976993756 @default.
• W4377011217 cites W1981318638 @default.
• W4377011217 cites W1989970158 @default.
• W4377011217 cites W1991332015 @default.
• W4377011217 cites W2004704626 @default.
• W4377011217 cites W2011947580 @default.
• W4377011217 cites W2012433802 @default.
• W4377011217 cites W2014827180 @default.
• W4377011217 cites W2017672062 @default.
• W4377011217 cites W2017752178 @default.
• W4377011217 cites W2034221138 @default.
• W4377011217 cites W2034602045 @default.
• W4377011217 cites W2040252238 @default.
• W4377011217 cites W2044089473 @default.
• W4377011217 cites W2045008815 @default.
• W4377011217 cites W2049385791 @default.
• W4377011217 cites W2056606217 @default.
• W4377011217 cites W2060397148 @default.
• W4377011217 cites W2068111737 @default.
• W4377011217 cites W2071529367 @default.
• W4377011217 cites W2075806746 @default.
• W4377011217 cites W2077773639 @default.
• W4377011217 cites W2099085143 @default.
• W4377011217 cites W2115904668 @default.
• W4377011217 cites W2122732268 @default.
• W4377011217 cites W2130402304 @default.
• W4377011217 cites W2133180000 @default.
• W4377011217 cites W2141708285 @default.
• W4377011217 cites W2145661651 @default.
• W4377011217 cites W2157253302 @default.
• W4377011217 cites W2159133121 @default.
• W4377011217 cites W2163013660 @default.
• W4377011217 cites W2168034721 @default.
• W4377011217 cites W2180943013 @default.
• W4377011217 cites W2270819285 @default.
• W4377011217 cites W2314068693 @default.
• W4377011217 cites W2518536270 @default.
• W4377011217 cites W2566571331 @default.
• W4377011217 cites W2590902165 @default.
• W4377011217 cites W2602783738 @default.
• W4377011217 cites W2751663063 @default.
• W4377011217 cites W2765256236 @default.
• W4377011217 cites W2884403858 @default.
• W4377011217 cites W2901786782 @default.
• W4377011217 cites W2902620929 @default.
• W4377011217 cites W2917263971 @default.
• W4377011217 cites W2925599397 @default.
• W4377011217 cites W2945345169 @default.
• W4377011217 cites W2949592035 @default.
• W4377011217 cites W2964362771 @default.
• W4377011217 cites W2972265869 @default.
• W4377011217 cites W2980028232 @default.
• W4377011217 cites W3004683268 @default.
• W4377011217 cites W3017088606 @default.
• W4377011217 cites W3083060968 @default.
• W4377011217 cites W3089756838 @default.
• W4377011217 cites W3093143379 @default.
• W4377011217 cites W3127255341 @default.
• W4377011217 cites W3138868253 @default.
• W4377011217 cites W3158546972 @default.
• W4377011217 cites W3197211040 @default.
• W4377011217 cites W3200143146 @default.
• W4377011217 cites W3209669212 @default.
• W4377011217 cites W3211183578 @default.
• W4377011217 cites W3213316449 @default.
• W4377011217 cites W4200484628 @default.
• W4377011217 cites W4213220407 @default.
• W4377011217 cites W4220691247 @default.
• W4377011217 cites W4225125703 @default.
• W4377011217 cites W4296167903 @default.
• W4377011217 cites W4308182605 @default.
• W4377011217 doi "https://doi.org/10.2147/jaa.s404670" @default.
• W4377011217 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37197194" @default.
• W4377011217 hasPublicationYear "2023" @default.
• W4377011217 type Work @default.
• W4377011217 citedByCount "0" @default.
• W4377011217 crossrefType "journal-article" @default.
• W4377011217 hasAuthorship W4377011217A5054859305 @default.
• W4377011217 hasAuthorship W4377011217A5067822778 @default.
• W4377011217 hasAuthorship W4377011217A5067895480 @default.
• W4377011217 hasAuthorship W4377011217A5079311452 @default.
• W4377011217 hasBestOaLocation W43770112171 @default.

• next