Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377011253> ?p ?o ?g. }
- W4377011253 endingPage "154869" @default.
- W4377011253 startingPage "154869" @default.
- W4377011253 abstract "Neobavaisoflavone (NBIF), a natural active ingredient isolated from Psoralea, possesses anti-inflammatory, anti-cancer, and antioxidant properties; however, the anti-tumor mechanism of NBIF has not been thoroughly investigated, and the inhibitory effect and inhibitory pathway of NBIF on liver cancer are still unknown.Our study aimed to explore the effects of NBIF on hepatocellular carcinoma and its potential mechanisms.First, we detected the inhibition of NBIF on HCC cells by the CCK8 assay and then observed the morphological changes of the cells under the microscope. Besides, we analyzed the changes in the pyroptosis level of NBIF when inhibiting the cells through flow cytometry, immunofluorescence, and a western blot assay. Finally, we used a mouse tumor-bearing model to explore the effects of NBIF in vivo on HCCLM3 cells.NBIF-treated HCC cells exhibited specific features of pyroptosis. Analysis of pyroptosis-related protein levels revealed that NBIF primarily induced pyroptosis in HCC cells via the caspase-3-GSDME signaling pathway. Then, we demonstrated that NBIF impacted the protein expression of Tom20 by producing ROS in HCC cells, hence promoting the recruitment of Bax to mitochondria, activating caspase-3, cutting GSDME, and triggering pyroptosis.By activating ROS, NBIF was able to trigger pyroptosis in HCC cells, providing an experimental basis for the future study of new treatments for liver cancer." @default.
- W4377011253 created "2023-05-19" @default.
- W4377011253 creator A5016904534 @default.
- W4377011253 creator A5034646780 @default.
- W4377011253 creator A5037439609 @default.
- W4377011253 creator A5044367029 @default.
- W4377011253 creator A5055601718 @default.
- W4377011253 creator A5057345801 @default.
- W4377011253 creator A5060118564 @default.
- W4377011253 creator A5073309453 @default.
- W4377011253 creator A5073901861 @default.
- W4377011253 creator A5075381883 @default.
- W4377011253 creator A5088815716 @default.
- W4377011253 creator A5091130757 @default.
- W4377011253 date "2023-07-01" @default.
- W4377011253 modified "2023-09-26" @default.
- W4377011253 title "Neobavaisoflavone induces pyroptosis of liver cancer cells via Tom20 sensing the activated ROS signal" @default.
- W4377011253 cites W1864325817 @default.
- W4377011253 cites W1882905539 @default.
- W4377011253 cites W1968488436 @default.
- W4377011253 cites W1969524738 @default.
- W4377011253 cites W1976599392 @default.
- W4377011253 cites W1979889094 @default.
- W4377011253 cites W2002906231 @default.
- W4377011253 cites W2011538447 @default.
- W4377011253 cites W2024156622 @default.
- W4377011253 cites W2026021432 @default.
- W4377011253 cites W2032792738 @default.
- W4377011253 cites W2068291431 @default.
- W4377011253 cites W2071246885 @default.
- W4377011253 cites W2074747472 @default.
- W4377011253 cites W2079278825 @default.
- W4377011253 cites W2083999150 @default.
- W4377011253 cites W2084592583 @default.
- W4377011253 cites W2084708403 @default.
- W4377011253 cites W2095866442 @default.
- W4377011253 cites W2102144390 @default.
- W4377011253 cites W2109108939 @default.
- W4377011253 cites W2124081909 @default.
- W4377011253 cites W2140525205 @default.
- W4377011253 cites W2141621785 @default.
- W4377011253 cites W2165427652 @default.
- W4377011253 cites W2166682453 @default.
- W4377011253 cites W2175794645 @default.
- W4377011253 cites W2337387091 @default.
- W4377011253 cites W2344809681 @default.
- W4377011253 cites W2418806051 @default.
- W4377011253 cites W2462773201 @default.
- W4377011253 cites W2521479657 @default.
- W4377011253 cites W2564122215 @default.
- W4377011253 cites W2608687752 @default.
- W4377011253 cites W2610420640 @default.
- W4377011253 cites W2735953961 @default.
- W4377011253 cites W2766031263 @default.
- W4377011253 cites W2766752058 @default.
- W4377011253 cites W2770936091 @default.
- W4377011253 cites W2793218589 @default.
- W4377011253 cites W2805414697 @default.
- W4377011253 cites W2818139375 @default.
- W4377011253 cites W2883204623 @default.
- W4377011253 cites W2885385214 @default.
- W4377011253 cites W2893434864 @default.
- W4377011253 cites W2895588157 @default.
- W4377011253 cites W2911937431 @default.
- W4377011253 cites W2912896196 @default.
- W4377011253 cites W2917633868 @default.
- W4377011253 cites W2936083981 @default.
- W4377011253 cites W2941033601 @default.
- W4377011253 cites W2947588340 @default.
- W4377011253 cites W2983652778 @default.
- W4377011253 cites W3014902879 @default.
- W4377011253 cites W3138994282 @default.
- W4377011253 cites W4211025847 @default.
- W4377011253 cites W4211183069 @default.
- W4377011253 cites W4232620598 @default.
- W4377011253 doi "https://doi.org/10.1016/j.phymed.2023.154869" @default.
- W4377011253 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37196512" @default.
- W4377011253 hasPublicationYear "2023" @default.
- W4377011253 type Work @default.
- W4377011253 citedByCount "1" @default.
- W4377011253 countsByYear W43770112532023 @default.
- W4377011253 crossrefType "journal-article" @default.
- W4377011253 hasAuthorship W4377011253A5016904534 @default.
- W4377011253 hasAuthorship W4377011253A5034646780 @default.
- W4377011253 hasAuthorship W4377011253A5037439609 @default.
- W4377011253 hasAuthorship W4377011253A5044367029 @default.
- W4377011253 hasAuthorship W4377011253A5055601718 @default.
- W4377011253 hasAuthorship W4377011253A5057345801 @default.
- W4377011253 hasAuthorship W4377011253A5060118564 @default.
- W4377011253 hasAuthorship W4377011253A5073309453 @default.
- W4377011253 hasAuthorship W4377011253A5073901861 @default.
- W4377011253 hasAuthorship W4377011253A5075381883 @default.
- W4377011253 hasAuthorship W4377011253A5088815716 @default.
- W4377011253 hasAuthorship W4377011253A5091130757 @default.
- W4377011253 hasBestOaLocation W43770112531 @default.
- W4377011253 hasConcept C104317684 @default.
- W4377011253 hasConcept C121608353 @default.
- W4377011253 hasConcept C153911025 @default.