FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377011284> ?p ?o ?g. }

• W4377011284 endingPage "137299" @default.
• W4377011284 startingPage "137299" @default.
• W4377011284 abstract "Glucagon-like peptide-1 receptor (GLP-1R) agonists are common type 2 diabetes medications that have been repurposed for adult chronic weight management. Clinical trials suggest this class may also be beneficial for obesity in pediatric populations. Since several GLP-1R agonists cross the blood–brain barrier, it is important to understand how postnatal developmental exposure to GLP-1R agonists might affect brain structure and function later in life. Toward that end, we systemically treated male and female C57BL/6 mice with the GLP-1R agonist exendin-4 (0.5 mg/kg, twice daily) or saline from postnatal day 14 to 21, then allowed uninterrupted development to young adulthood. Beginning at 7 weeks of age, we performed open field and marble burying tests to assess motor behavior and the spontaneous location recognition (SLR) task to assess hippocampal-dependent pattern separation and memory. Mice were sacrificed, and we counted ventral hippocampal mossy cells, as we have recently shown that most murine hippocampal neuronal GLP-1R is expressed in this cell population. We found that GLP-1R agonist treatment did not alter P14-P21 weight gain, but modestly reduced young adult open field distance traveled and marble burying. Despite these motor changes, there was no effect on SLR memory performance or time spent investigating objects. Finally, we did not detect any changes in ventral mossy cell number using two different markers. These data suggest developmental exposure to GLP-1R agonists might have specific rather than global effects on behavior later in life and that extensive additional study is necessary to clarify how drug timing and dose affect distinct constellations of behavior in young adulthood." @default.
• W4377011284 created "2023-05-19" @default.
• W4377011284 creator A5015222190 @default.
• W4377011284 creator A5019903202 @default.
• W4377011284 creator A5040191785 @default.
• W4377011284 creator A5079012986 @default.
• W4377011284 creator A5086389943 @default.
• W4377011284 date "2023-06-01" @default.
• W4377011284 modified "2023-10-17" @default.
• W4377011284 title "Effects of repeated developmental GLP-1R agonist exposure on young adult behavior and hippocampal structure in mice" @default.
• W4377011284 cites W1988199645 @default.
• W4377011284 cites W1995019327 @default.
• W4377011284 cites W2001664504 @default.
• W4377011284 cites W2025724602 @default.
• W4377011284 cites W2026566679 @default.
• W4377011284 cites W2029549266 @default.
• W4377011284 cites W2044784970 @default.
• W4377011284 cites W2057410639 @default.
• W4377011284 cites W2065372294 @default.
• W4377011284 cites W2086172137 @default.
• W4377011284 cites W2126057547 @default.
• W4377011284 cites W2161258328 @default.
• W4377011284 cites W2167279371 @default.
• W4377011284 cites W2311961170 @default.
• W4377011284 cites W2343439038 @default.
• W4377011284 cites W2491404798 @default.
• W4377011284 cites W2493346837 @default.
• W4377011284 cites W2582675973 @default.
• W4377011284 cites W2593691145 @default.
• W4377011284 cites W2610516457 @default.
• W4377011284 cites W2616570371 @default.
• W4377011284 cites W2766706007 @default.
• W4377011284 cites W2787829706 @default.
• W4377011284 cites W2885588864 @default.
• W4377011284 cites W2888081881 @default.
• W4377011284 cites W2912212992 @default.
• W4377011284 cites W2912930615 @default.
• W4377011284 cites W2978840913 @default.
• W4377011284 cites W3005805429 @default.
• W4377011284 cites W3013213902 @default.
• W4377011284 cites W3028225906 @default.
• W4377011284 cites W3127371223 @default.
• W4377011284 cites W3127587980 @default.
• W4377011284 cites W3152706179 @default.
• W4377011284 cites W3210133062 @default.
• W4377011284 cites W4291552694 @default.
• W4377011284 cites W4294162864 @default.
• W4377011284 cites W4294671208 @default.
• W4377011284 cites W4308053954 @default.
• W4377011284 cites W807162506 @default.
• W4377011284 doi "https://doi.org/10.1016/j.neulet.2023.137299" @default.
• W4377011284 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37196974" @default.
• W4377011284 hasPublicationYear "2023" @default.
• W4377011284 type Work @default.
• W4377011284 citedByCount "0" @default.
• W4377011284 crossrefType "journal-article" @default.
• W4377011284 hasAuthorship W4377011284A5015222190 @default.
• W4377011284 hasAuthorship W4377011284A5019903202 @default.
• W4377011284 hasAuthorship W4377011284A5040191785 @default.
• W4377011284 hasAuthorship W4377011284A5079012986 @default.
• W4377011284 hasAuthorship W4377011284A5086389943 @default.
• W4377011284 hasConcept C126322002 @default.
• W4377011284 hasConcept C134018914 @default.
• W4377011284 hasConcept C148762608 @default.
• W4377011284 hasConcept C169760540 @default.
• W4377011284 hasConcept C170493617 @default.
• W4377011284 hasConcept C2778938600 @default.
• W4377011284 hasConcept C2779085643 @default.
• W4377011284 hasConcept C2781161787 @default.
• W4377011284 hasConcept C2908647359 @default.
• W4377011284 hasConcept C71924100 @default.
• W4377011284 hasConcept C86803240 @default.
• W4377011284 hasConcept C99454951 @default.
• W4377011284 hasConceptScore W4377011284C126322002 @default.
• W4377011284 hasConceptScore W4377011284C134018914 @default.
• W4377011284 hasConceptScore W4377011284C148762608 @default.
• W4377011284 hasConceptScore W4377011284C169760540 @default.
• W4377011284 hasConceptScore W4377011284C170493617 @default.
• W4377011284 hasConceptScore W4377011284C2778938600 @default.
• W4377011284 hasConceptScore W4377011284C2779085643 @default.
• W4377011284 hasConceptScore W4377011284C2781161787 @default.
• W4377011284 hasConceptScore W4377011284C2908647359 @default.
• W4377011284 hasConceptScore W4377011284C71924100 @default.
• W4377011284 hasConceptScore W4377011284C86803240 @default.
• W4377011284 hasConceptScore W4377011284C99454951 @default.
• W4377011284 hasFunder F4320332161 @default.
• W4377011284 hasFunder F4320334282 @default.
• W4377011284 hasFunder F4320337346 @default.
• W4377011284 hasLocation W43770112841 @default.
• W4377011284 hasLocation W43770112842 @default.
• W4377011284 hasOpenAccess W4377011284 @default.
• W4377011284 hasPrimaryLocation W43770112841 @default.
• W4377011284 hasRelatedWork W2027913950 @default.
• W4377011284 hasRelatedWork W2034583712 @default.
• W4377011284 hasRelatedWork W2050423574 @default.
• W4377011284 hasRelatedWork W2058205365 @default.
• W4377011284 hasRelatedWork W2063619316 @default.
• W4377011284 hasRelatedWork W2074821979 @default.

• next