Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377011304> ?p ?o ?g. }
- W4377011304 abstract "Abstract A primary role of the liver is to regulate whole body glucose homeostasis. Glucokinase (GCK) is the main hexokinase (HK) expressed in hepatocytes and functions to phosphorylate the glucose that enters via GLUT transporters to become glucose-6-phosphate (G6P), which subsequently commits glucose to enter downstream anabolic and catabolic pathways. In the recent years, hexokinase domain-containing-1 (HKDC1), a novel 5th HK, has been characterized by our group and others. Its expression profile varies but has been identified to have low basal expression in normal liver but increases during states of stress including pregnancy, nonalcoholic fatty liver disease (NAFLD), and liver cancer. Here, we have developed a stable overexpression model of hepatic HKDC1 in mice to examine its effect on metabolic regulation. We found that HKDC1 overexpression, over time, causes impaired glucose homeostasis in male mice and shifts glucose metabolism towards anabolic pathways with an increase in nucleotide synthesis. Furthermore, we observed these mice to have larger liver sizes due to greater hepatocyte proliferative potential and cell size, which in part, is mediated via yes-associated protein (YAP) signaling." @default.
- W4377011304 created "2023-05-19" @default.
- W4377011304 creator A5000266498 @default.
- W4377011304 creator A5019948827 @default.
- W4377011304 creator A5020254328 @default.
- W4377011304 creator A5024755542 @default.
- W4377011304 creator A5035415054 @default.
- W4377011304 creator A5047549845 @default.
- W4377011304 creator A5053426302 @default.
- W4377011304 creator A5063072342 @default.
- W4377011304 creator A5075065022 @default.
- W4377011304 creator A5077943788 @default.
- W4377011304 creator A5083106775 @default.
- W4377011304 date "2023-05-17" @default.
- W4377011304 modified "2023-10-16" @default.
- W4377011304 title "Liver-specific overexpression of HKDC1 increases hepatocyte size and proliferative capacity" @default.
- W4377011304 cites W1503760388 @default.
- W4377011304 cites W1571767699 @default.
- W4377011304 cites W1782420827 @default.
- W4377011304 cites W2002022639 @default.
- W4377011304 cites W2009682967 @default.
- W4377011304 cites W2015509835 @default.
- W4377011304 cites W2016670036 @default.
- W4377011304 cites W2044344375 @default.
- W4377011304 cites W2061707481 @default.
- W4377011304 cites W2064263174 @default.
- W4377011304 cites W2090632954 @default.
- W4377011304 cites W2095799421 @default.
- W4377011304 cites W2129316761 @default.
- W4377011304 cites W2140723615 @default.
- W4377011304 cites W2142225943 @default.
- W4377011304 cites W2146885685 @default.
- W4377011304 cites W2151647131 @default.
- W4377011304 cites W2152311269 @default.
- W4377011304 cites W2160774278 @default.
- W4377011304 cites W2162928593 @default.
- W4377011304 cites W2163269287 @default.
- W4377011304 cites W2223535266 @default.
- W4377011304 cites W2296459635 @default.
- W4377011304 cites W2296585153 @default.
- W4377011304 cites W2346611535 @default.
- W4377011304 cites W2486207088 @default.
- W4377011304 cites W2562001879 @default.
- W4377011304 cites W2790744410 @default.
- W4377011304 cites W2792246690 @default.
- W4377011304 cites W2898656941 @default.
- W4377011304 cites W2902610570 @default.
- W4377011304 cites W2905541293 @default.
- W4377011304 cites W2919743327 @default.
- W4377011304 cites W2954463691 @default.
- W4377011304 cites W2988895480 @default.
- W4377011304 cites W3002407185 @default.
- W4377011304 cites W3003265560 @default.
- W4377011304 cites W3037996985 @default.
- W4377011304 cites W3086015287 @default.
- W4377011304 cites W3112017976 @default.
- W4377011304 cites W3117083078 @default.
- W4377011304 cites W3139011427 @default.
- W4377011304 cites W4288462116 @default.
- W4377011304 doi "https://doi.org/10.1038/s41598-023-33924-3" @default.
- W4377011304 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37198225" @default.
- W4377011304 hasPublicationYear "2023" @default.
- W4377011304 type Work @default.
- W4377011304 citedByCount "0" @default.
- W4377011304 crossrefType "journal-article" @default.
- W4377011304 hasAuthorship W4377011304A5000266498 @default.
- W4377011304 hasAuthorship W4377011304A5019948827 @default.
- W4377011304 hasAuthorship W4377011304A5020254328 @default.
- W4377011304 hasAuthorship W4377011304A5024755542 @default.
- W4377011304 hasAuthorship W4377011304A5035415054 @default.
- W4377011304 hasAuthorship W4377011304A5047549845 @default.
- W4377011304 hasAuthorship W4377011304A5053426302 @default.
- W4377011304 hasAuthorship W4377011304A5063072342 @default.
- W4377011304 hasAuthorship W4377011304A5075065022 @default.
- W4377011304 hasAuthorship W4377011304A5077943788 @default.
- W4377011304 hasAuthorship W4377011304A5083106775 @default.
- W4377011304 hasBestOaLocation W43770113041 @default.
- W4377011304 hasConcept C1008401 @default.
- W4377011304 hasConcept C104317684 @default.
- W4377011304 hasConcept C126322002 @default.
- W4377011304 hasConcept C127561419 @default.
- W4377011304 hasConcept C134018914 @default.
- W4377011304 hasConcept C161573976 @default.
- W4377011304 hasConcept C17093226 @default.
- W4377011304 hasConcept C185592680 @default.
- W4377011304 hasConcept C20251656 @default.
- W4377011304 hasConcept C202751555 @default.
- W4377011304 hasConcept C2776200302 @default.
- W4377011304 hasConcept C2776954865 @default.
- W4377011304 hasConcept C2777391703 @default.
- W4377011304 hasConcept C2778772119 @default.
- W4377011304 hasConcept C2779134260 @default.
- W4377011304 hasConcept C2779306644 @default.
- W4377011304 hasConcept C2779826832 @default.
- W4377011304 hasConcept C3018667095 @default.
- W4377011304 hasConcept C55493867 @default.
- W4377011304 hasConcept C62231903 @default.
- W4377011304 hasConcept C63645605 @default.
- W4377011304 hasConcept C71924100 @default.
- W4377011304 hasConcept C86803240 @default.