FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377011379> ?p ?o ?g. }

• W4377011379 endingPage "944" @default.
• W4377011379 startingPage "936" @default.
• W4377011379 abstract "The circulating metabolome is altered in multiple sclerosis (MS), but its prognostic capabilities have not been extensively explored. Lipid metabolites might be of particular interest due to their multiple roles in the brain, as they can serve as structural components, energy sources, and bioactive molecules. Gaining a deeper understanding of the disease may be possible by examining the lipid metabolism in the periphery, which serves as the primary source of lipids for the brain.To determine if altered serum lipid metabolites are associated with the risk of relapse and disability in children with MS.We collected serum samples from 61 participants with pediatric-onset MS within 4 years of disease onset. Prospective longitudinal relapse data and cross-sectional disability measures (Expanded Disability Status Scale [EDSS]) were collected. Serum metabolomics was performed using untargeted liquid chromatography and mass spectrometry. Individual lipid metabolites were clustered into pre-defined pathways. The associations between clusters of metabolites and relapse rate and EDSS score were estimated utilizing negative binomial and linear regression models, respectively.We found that serum acylcarnitines (relapse rate: normalized enrichment score [NES] = 2.1, q = 1.03E-04; EDSS: NES = 1.7, q = 0.02) and poly-unsaturated fatty acids (relapse rate: NES = 1.6, q = 0.047; EDSS: NES = 1.9, q = 0.005) were associated with higher relapse rates and EDSS, while serum phosphatidylethanolamines (relapse rate: NES = -2.3, q = 0.002; EDSS: NES = -2.1, q = 0.004), plasmalogens (relapse rate: NES = -2.5, q = 5.81E-04; EDSS: NES = -2.1, q = 0.004), and primary bile acid metabolites (relapse rate: NES = -2.0, q = 0.02; EDSS: NES = -1.9, q = 0.02) were associated with lower relapse rates and lower EDSS.This study supports the role of some lipid metabolites in pediatric MS relapses and disability." @default.
• W4377011379 created "2023-05-19" @default.
• W4377011379 creator A5012993038 @default.
• W4377011379 creator A5014593102 @default.
• W4377011379 creator A5016390221 @default.
• W4377011379 creator A5035792887 @default.
• W4377011379 creator A5057605708 @default.
• W4377011379 creator A5057914492 @default.
• W4377011379 creator A5069189512 @default.
• W4377011379 creator A5076230774 @default.
• W4377011379 creator A5085030272 @default.
• W4377011379 date "2023-05-18" @default.
• W4377011379 modified "2023-10-17" @default.
• W4377011379 title "Several serum lipid metabolites are associated with relapse risk in pediatric-onset multiple sclerosis" @default.
• W4377011379 cites W1812391321 @default.
• W4377011379 cites W1938038381 @default.
• W4377011379 cites W1966327575 @default.
• W4377011379 cites W1966833346 @default.
• W4377011379 cites W1980270094 @default.
• W4377011379 cites W2000849147 @default.
• W4377011379 cites W2016319161 @default.
• W4377011379 cites W2028621708 @default.
• W4377011379 cites W2036863084 @default.
• W4377011379 cites W2087968417 @default.
• W4377011379 cites W2105632943 @default.
• W4377011379 cites W2130410032 @default.
• W4377011379 cites W2169353806 @default.
• W4377011379 cites W2411561471 @default.
• W4377011379 cites W2581834170 @default.
• W4377011379 cites W2762023794 @default.
• W4377011379 cites W2768617092 @default.
• W4377011379 cites W2891661090 @default.
• W4377011379 cites W2894410744 @default.
• W4377011379 cites W2920798634 @default.
• W4377011379 cites W2944786249 @default.
• W4377011379 cites W2956651315 @default.
• W4377011379 cites W2965647501 @default.
• W4377011379 cites W2966057072 @default.
• W4377011379 cites W2967703846 @default.
• W4377011379 cites W3001913541 @default.
• W4377011379 cites W3011760433 @default.
• W4377011379 cites W3097803201 @default.
• W4377011379 cites W3099748118 @default.
• W4377011379 cites W3111801841 @default.
• W4377011379 cites W3120783654 @default.
• W4377011379 cites W3153190779 @default.
• W4377011379 cites W3207370032 @default.
• W4377011379 cites W3208698611 @default.
• W4377011379 cites W3209083541 @default.
• W4377011379 cites W4253381763 @default.
• W4377011379 cites W4282963565 @default.
• W4377011379 cites W4284974159 @default.
• W4377011379 doi "https://doi.org/10.1177/13524585231171517" @default.
• W4377011379 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37199529" @default.
• W4377011379 hasPublicationYear "2023" @default.
• W4377011379 type Work @default.
• W4377011379 citedByCount "0" @default.
• W4377011379 crossrefType "journal-article" @default.
• W4377011379 hasAuthorship W4377011379A5012993038 @default.
• W4377011379 hasAuthorship W4377011379A5014593102 @default.
• W4377011379 hasAuthorship W4377011379A5016390221 @default.
• W4377011379 hasAuthorship W4377011379A5035792887 @default.
• W4377011379 hasAuthorship W4377011379A5057605708 @default.
• W4377011379 hasAuthorship W4377011379A5057914492 @default.
• W4377011379 hasAuthorship W4377011379A5069189512 @default.
• W4377011379 hasAuthorship W4377011379A5076230774 @default.
• W4377011379 hasAuthorship W4377011379A5085030272 @default.
• W4377011379 hasBestOaLocation W43770113792 @default.
• W4377011379 hasConcept C126322002 @default.
• W4377011379 hasConcept C134018914 @default.
• W4377011379 hasConcept C135870905 @default.
• W4377011379 hasConcept C203014093 @default.
• W4377011379 hasConcept C2777477808 @default.
• W4377011379 hasConcept C2780640218 @default.
• W4377011379 hasConcept C2780892749 @default.
• W4377011379 hasConcept C2781197716 @default.
• W4377011379 hasConcept C42407357 @default.
• W4377011379 hasConcept C4733338 @default.
• W4377011379 hasConcept C55493867 @default.
• W4377011379 hasConcept C71924100 @default.
• W4377011379 hasConcept C86803240 @default.
• W4377011379 hasConceptScore W4377011379C126322002 @default.
• W4377011379 hasConceptScore W4377011379C134018914 @default.
• W4377011379 hasConceptScore W4377011379C135870905 @default.
• W4377011379 hasConceptScore W4377011379C203014093 @default.
• W4377011379 hasConceptScore W4377011379C2777477808 @default.
• W4377011379 hasConceptScore W4377011379C2780640218 @default.
• W4377011379 hasConceptScore W4377011379C2780892749 @default.
• W4377011379 hasConceptScore W4377011379C2781197716 @default.
• W4377011379 hasConceptScore W4377011379C42407357 @default.
• W4377011379 hasConceptScore W4377011379C4733338 @default.
• W4377011379 hasConceptScore W4377011379C55493867 @default.
• W4377011379 hasConceptScore W4377011379C71924100 @default.
• W4377011379 hasConceptScore W4377011379C86803240 @default.
• W4377011379 hasFunder F4320306114 @default.
• W4377011379 hasFunder F4320306161 @default.
• W4377011379 hasFunder F4320332161 @default.
• W4377011379 hasIssue "8" @default.

• next