FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377011386> ?p ?o ?g. }

• W4377011386 endingPage "2039" @default.
• W4377011386 startingPage "2023" @default.
• W4377011386 abstract "Mesenchymal stem cells (MSCs) have become novel therapeutic agents for the treatment of inflammatory bowel diseases (IBDs). However, the precise cellular and molecular mechanisms by which MSCs restore intestinal tissue homeostasis and repair the epithelial barrier have not been well elucidated. This study aimed to investigate the therapeutic effects and possible mechanisms of human MSCs in the treatment of experimental colitis.We performed an integrative transcriptomic, proteomic, untargeted metabolomics, and gut microbiota analyses in a dextran sulfate sodium (DSS)-induced IBD mouse model. The cell viability of IEC-6 cells was determined by Cell Counting Kit-8 (CCK-8) assay. The expression of MUC-1 and ferroptosis-related genes were determined by immunohistochemical staining, Western blot, and real-time quantitative polymerase chain reaction (RT-qPCR).Mice treated with MSCs showed notable amelioration in the severity of DSS-induced colitis, which was associated with reduced levels of proinflammatory cytokines and restoration of the lymphocyte subpopulation balance. Treatment with MSC restored the gut microbiota and altered their metabolites in DSS-induced IBD mice. The 16s rDNA sequencing showed that treatment with MSC modulated the composition of probiotics, including the upregulation of the contents of Firmicutes, Lactobacillus, Blautia, Clostridia, and Helicobacter bacteria in mouse colons. Protein proteomics and transcriptome analyses revealed that pathways related to cell immune responses, including inflammatory cytokines, were suppressed in the MSC group. The ferroptosis-related gene, MUC-1, was significantly upregulated in the MSC-treated group. MUC-1-inhibition experiments indicated that MUC-1 was essential for epithelial cell growth. Through overexpression of MUC-1, it showed that upregulation of SLC7A11 and GPX4, and downregulation of ACSL4 in erastin and RSL3-treated IEC-6 cells, respectively.This study described a mechanism by which treatment with MSCs ameliorated the severity of DSS-induced colitis by modulating the gut microbiota, immune response, and the MUC-1 pathway." @default.
• W4377011386 created "2023-05-19" @default.
• W4377011386 creator A5001913247 @default.
• W4377011386 creator A5003846107 @default.
• W4377011386 creator A5015643825 @default.
• W4377011386 creator A5027222214 @default.
• W4377011386 creator A5035893717 @default.
• W4377011386 creator A5053048373 @default.
• W4377011386 creator A5056204035 @default.
• W4377011386 date "2023-05-01" @default.
• W4377011386 modified "2023-09-30" @default.
• W4377011386 title "Mesenchymal Stem Cells Ameliorate DSS-Induced Experimental Colitis by Modulating the Gut Microbiota and MUC-1 Pathway" @default.
• W4377011386 cites W2074218230 @default.
• W4377011386 cites W2097711312 @default.
• W4377011386 cites W2115788075 @default.
• W4377011386 cites W2134387432 @default.
• W4377011386 cites W2193331464 @default.
• W4377011386 cites W2560869672 @default.
• W4377011386 cites W2620756707 @default.
• W4377011386 cites W2762360556 @default.
• W4377011386 cites W2778416039 @default.
• W4377011386 cites W2780607073 @default.
• W4377011386 cites W2791416031 @default.
• W4377011386 cites W2797737760 @default.
• W4377011386 cites W2895927591 @default.
• W4377011386 cites W2916244827 @default.
• W4377011386 cites W2924471609 @default.
• W4377011386 cites W2965698862 @default.
• W4377011386 cites W2995856749 @default.
• W4377011386 cites W3000462699 @default.
• W4377011386 cites W3003524859 @default.
• W4377011386 cites W3006796998 @default.
• W4377011386 cites W3043473212 @default.
• W4377011386 cites W3077764649 @default.
• W4377011386 cites W3096586635 @default.
• W4377011386 cites W3096912605 @default.
• W4377011386 cites W3110012916 @default.
• W4377011386 cites W3111110166 @default.
• W4377011386 cites W3139471368 @default.
• W4377011386 cites W3159833349 @default.
• W4377011386 cites W3162305544 @default.
• W4377011386 cites W3164779777 @default.
• W4377011386 cites W3175849586 @default.
• W4377011386 cites W3180035618 @default.
• W4377011386 cites W3184840472 @default.
• W4377011386 cites W3190695126 @default.
• W4377011386 cites W3199120381 @default.
• W4377011386 cites W3201219558 @default.
• W4377011386 cites W3204988140 @default.
• W4377011386 cites W3208691458 @default.
• W4377011386 cites W3217121926 @default.
• W4377011386 cites W4220734938 @default.
• W4377011386 cites W4220862202 @default.
• W4377011386 cites W4221089848 @default.
• W4377011386 cites W4282941012 @default.
• W4377011386 cites W4283724728 @default.
• W4377011386 cites W4286491287 @default.
• W4377011386 doi "https://doi.org/10.2147/jir.s402592" @default.
• W4377011386 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37197438" @default.
• W4377011386 hasPublicationYear "2023" @default.
• W4377011386 type Work @default.
• W4377011386 citedByCount "0" @default.
• W4377011386 crossrefType "journal-article" @default.
• W4377011386 hasAuthorship W4377011386A5001913247 @default.
• W4377011386 hasAuthorship W4377011386A5003846107 @default.
• W4377011386 hasAuthorship W4377011386A5015643825 @default.
• W4377011386 hasAuthorship W4377011386A5027222214 @default.
• W4377011386 hasAuthorship W4377011386A5035893717 @default.
• W4377011386 hasAuthorship W4377011386A5053048373 @default.
• W4377011386 hasAuthorship W4377011386A5056204035 @default.
• W4377011386 hasBestOaLocation W43770113861 @default.
• W4377011386 hasConcept C10116572 @default.
• W4377011386 hasConcept C104317684 @default.
• W4377011386 hasConcept C127561419 @default.
• W4377011386 hasConcept C142724271 @default.
• W4377011386 hasConcept C164027704 @default.
• W4377011386 hasConcept C198826908 @default.
• W4377011386 hasConcept C203014093 @default.
• W4377011386 hasConcept C2775862500 @default.
• W4377011386 hasConcept C2776914184 @default.
• W4377011386 hasConcept C2778260677 @default.
• W4377011386 hasConcept C2779134260 @default.
• W4377011386 hasConcept C28328180 @default.
• W4377011386 hasConcept C539455810 @default.
• W4377011386 hasConcept C55427017 @default.
• W4377011386 hasConcept C55493867 @default.
• W4377011386 hasConcept C71924100 @default.
• W4377011386 hasConcept C86803240 @default.
• W4377011386 hasConcept C8891405 @default.
• W4377011386 hasConcept C95444343 @default.
• W4377011386 hasConceptScore W4377011386C10116572 @default.
• W4377011386 hasConceptScore W4377011386C104317684 @default.
• W4377011386 hasConceptScore W4377011386C127561419 @default.
• W4377011386 hasConceptScore W4377011386C142724271 @default.
• W4377011386 hasConceptScore W4377011386C164027704 @default.
• W4377011386 hasConceptScore W4377011386C198826908 @default.
• W4377011386 hasConceptScore W4377011386C203014093 @default.
• W4377011386 hasConceptScore W4377011386C2775862500 @default.

• next