Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377011424> ?p ?o ?g. }
- W4377011424 endingPage "3175" @default.
- W4377011424 startingPage "3162" @default.
- W4377011424 abstract "Abstract CD8+ T lymphocyte‐mediated immunity strategies have represented attractive weapons against breast cancer (BC) recently. However, the mechanisms underlying CD8+ T‐lymphocyte infiltration still remain obscure. Here, using bioinformatics analysis, we identified four hub prognostic genes related to CD8+ T‐lymphocyte infiltration (CHMP4A, CXCL9, GRHL2, and RPS29), among which CHMP4A was the most significant gene. High CHMP4A mRNA expression was significantly associated with longer overall survival (OS) in BC patients. Functional experiments showed that CHMP4A had the ability to promote CD8+ T‐lymphocyte recruitment and infiltration and suppressed BC growth in vitro and in vivo. Mechanistically, CHMP4A stimulates CD8+ T‐lymphocyte infiltration by downregulating LSD1 expression, leading to HERV dsRNA accumulation, and promoting IFNβ and its downstream chemokine production. Collectively, CHMP4A is not only a novel positive predictor for prognosis in BC but also a stimulator of CD8+ T‐lymphocyte infiltration regulated by the LSD1/IFNβ pathway. This study suggests that CHMP4A may be a novel target for improving the effectiveness of immunotherapy in patients with BC." @default.
- W4377011424 created "2023-05-19" @default.
- W4377011424 creator A5003573240 @default.
- W4377011424 creator A5014048532 @default.
- W4377011424 creator A5017228332 @default.
- W4377011424 creator A5020966645 @default.
- W4377011424 creator A5036780946 @default.
- W4377011424 creator A5046585294 @default.
- W4377011424 creator A5051689229 @default.
- W4377011424 creator A5062400655 @default.
- W4377011424 creator A5066440914 @default.
- W4377011424 date "2023-05-18" @default.
- W4377011424 modified "2023-10-01" @default.
- W4377011424 title "<scp>CHMP4A</scp> stimulates <scp>CD8</scp> + T‐lymphocyte infiltration and inhibits breast tumor growth via the <scp>LSD1</scp> / <scp>IFNβ</scp> axis" @default.
- W4377011424 cites W2011327324 @default.
- W4377011424 cites W2033135715 @default.
- W4377011424 cites W2033278321 @default.
- W4377011424 cites W2036431563 @default.
- W4377011424 cites W2042954200 @default.
- W4377011424 cites W2047484856 @default.
- W4377011424 cites W2081796577 @default.
- W4377011424 cites W2098506409 @default.
- W4377011424 cites W2166456692 @default.
- W4377011424 cites W2536121412 @default.
- W4377011424 cites W2569325224 @default.
- W4377011424 cites W2590455223 @default.
- W4377011424 cites W2607078661 @default.
- W4377011424 cites W2762577984 @default.
- W4377011424 cites W2809237949 @default.
- W4377011424 cites W2885441485 @default.
- W4377011424 cites W2904330796 @default.
- W4377011424 cites W2949498852 @default.
- W4377011424 cites W2951718210 @default.
- W4377011424 cites W2955932976 @default.
- W4377011424 cites W2982017357 @default.
- W4377011424 cites W2982449517 @default.
- W4377011424 cites W3012963315 @default.
- W4377011424 cites W3088678336 @default.
- W4377011424 cites W3111500645 @default.
- W4377011424 cites W3134263637 @default.
- W4377011424 cites W3159523017 @default.
- W4377011424 cites W3180654212 @default.
- W4377011424 cites W3209657850 @default.
- W4377011424 cites W3214528175 @default.
- W4377011424 cites W4200620790 @default.
- W4377011424 cites W4205537349 @default.
- W4377011424 cites W4220735045 @default.
- W4377011424 cites W4220901250 @default.
- W4377011424 cites W4224315076 @default.
- W4377011424 cites W4286374490 @default.
- W4377011424 cites W4289595377 @default.
- W4377011424 cites W4292485115 @default.
- W4377011424 cites W4377011424 @default.
- W4377011424 doi "https://doi.org/10.1111/cas.15844" @default.
- W4377011424 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37198999" @default.
- W4377011424 hasPublicationYear "2023" @default.
- W4377011424 type Work @default.
- W4377011424 citedByCount "1" @default.
- W4377011424 countsByYear W43770114242023 @default.
- W4377011424 crossrefType "journal-article" @default.
- W4377011424 hasAuthorship W4377011424A5003573240 @default.
- W4377011424 hasAuthorship W4377011424A5014048532 @default.
- W4377011424 hasAuthorship W4377011424A5017228332 @default.
- W4377011424 hasAuthorship W4377011424A5020966645 @default.
- W4377011424 hasAuthorship W4377011424A5036780946 @default.
- W4377011424 hasAuthorship W4377011424A5046585294 @default.
- W4377011424 hasAuthorship W4377011424A5051689229 @default.
- W4377011424 hasAuthorship W4377011424A5062400655 @default.
- W4377011424 hasAuthorship W4377011424A5066440914 @default.
- W4377011424 hasBestOaLocation W43770114241 @default.
- W4377011424 hasConcept C121332964 @default.
- W4377011424 hasConcept C13373296 @default.
- W4377011424 hasConcept C153400128 @default.
- W4377011424 hasConcept C167672396 @default.
- W4377011424 hasConcept C203014093 @default.
- W4377011424 hasConcept C2777761686 @default.
- W4377011424 hasConcept C2992881475 @default.
- W4377011424 hasConcept C502942594 @default.
- W4377011424 hasConcept C86803240 @default.
- W4377011424 hasConcept C8891405 @default.
- W4377011424 hasConcept C97355855 @default.
- W4377011424 hasConceptScore W4377011424C121332964 @default.
- W4377011424 hasConceptScore W4377011424C13373296 @default.
- W4377011424 hasConceptScore W4377011424C153400128 @default.
- W4377011424 hasConceptScore W4377011424C167672396 @default.
- W4377011424 hasConceptScore W4377011424C203014093 @default.
- W4377011424 hasConceptScore W4377011424C2777761686 @default.
- W4377011424 hasConceptScore W4377011424C2992881475 @default.
- W4377011424 hasConceptScore W4377011424C502942594 @default.
- W4377011424 hasConceptScore W4377011424C86803240 @default.
- W4377011424 hasConceptScore W4377011424C8891405 @default.
- W4377011424 hasConceptScore W4377011424C97355855 @default.
- W4377011424 hasIssue "8" @default.
- W4377011424 hasLocation W43770114241 @default.
- W4377011424 hasLocation W43770114242 @default.
- W4377011424 hasOpenAccess W4377011424 @default.
- W4377011424 hasPrimaryLocation W43770114241 @default.
- W4377011424 hasRelatedWork W1506984959 @default.