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- W4377011469 abstract "Seven previously undescribed diterpenoids, tinocrisposides A–D (1–4) and borapetic acids A (5), B (6), and C (7), together with 16 known compounds, were isolated from the stem of Tinospora crispa (Menispermaceae). The structures of the new isolates were elucidated by spectroscopic and chemical methods. The β-cell protective effect of the tested compounds was examined on insulin-secreting BRIN-BD11 cells under dexamethasone treatment. Diterpene glycosides 12, 14–16, and 18 presented a substantial protective effect on BRIN-BD11 cells treated with dexamethasone in a dose-dependent manner. Compounds 4 and 17 with two sugar moieties exhibited clear protective effects on β-cells." @default.
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- W4377011469 date "2023-05-18" @default.
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- W4377011469 title "Diterpenoids and Their Glycosides from the Stems of <i>Tinospora crispa</i> with Beta-Cell Protective Activity" @default.
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- W4377011469 doi "https://doi.org/10.1021/acs.jnatprod.3c00114" @default.
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