FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377011480> ?p ?o ?g. }

• W4377011480 abstract "Due to the high variance in response rates concerning anti-PD1 immunotherapy (IT), there is an unmet need to discover innovative biomarkers to predict immune checkpoint inhibitor (ICI)-efficacy. Our study included 62 Caucasian advanced-stage non-small cell lung cancer (NSCLC) patients treated with anti-PD1 ICI. Gut bacterial signatures were evaluated by metagenomic sequencing and correlated with progression-free survival (PFS), PD-L1 expression and other clinicopathological parameters. We confirmed the predictive role of PFS-related key bacteria with multivariate statistical models (Lasso- and Cox-regression) and validated on an additional patient cohort (n = 60). We find that alpha-diversity showed no significant difference in any comparison. However, there was a significant difference in beta-diversity between patients with long- (>6 months) vs. short (≤6 months) PFS and between chemotherapy (CHT)-treated vs. CHT-naive cases. Short PFS was associated with increased abundance of Firmicutes (F) and Actinobacteria phyla, whereas elevated abundance of Euryarchaeota was specific for low PD-L1 expression. F/Bacteroides (F/B) ratio was significantly increased in patients with short PFS. Multivariate analysis revealed an association between Alistipes shahii, Alistipes finegoldii, Barnesiella visceriola, and long PFS. In contrast, Streptococcus salivarius, Streptococcus vestibularis, and Bifidobacterium breve were associated with short PFS. Using Random Forest machine learning approach, we find that taxonomic profiles performed superiorly in predicting PFS (AUC = 0.74), while metabolic pathways including Amino Acid Synthesis and Fermentation were better predictors of PD-L1 expression (AUC = 0.87). We conclude that specific metagenomic features of the gut microbiome, including bacterial taxonomy and metabolic pathways might be suggestive of ICI efficacy and PD-L1 expression in NSCLC patients." @default.
• W4377011480 created "2023-05-19" @default.
• W4377011480 creator A5006056998 @default.
• W4377011480 creator A5010484767 @default.
• W4377011480 creator A5010575961 @default.
• W4377011480 creator A5020220994 @default.
• W4377011480 creator A5030361070 @default.
• W4377011480 creator A5041499764 @default.
• W4377011480 creator A5047899806 @default.
• W4377011480 creator A5057244028 @default.
• W4377011480 creator A5066209110 @default.
• W4377011480 creator A5066457628 @default.
• W4377011480 creator A5069675443 @default.
• W4377011480 creator A5080669646 @default.
• W4377011480 date "2023-05-12" @default.
• W4377011480 modified "2023-10-01" @default.
• W4377011480 title "Non-small cell lung cancer patients treated with Anti-PD1 immunotherapy show distinct microbial signatures and metabolic pathways according to progression-free survival and PD-L1 status" @default.
• W4377011480 cites W1971415551 @default.
• W4377011480 cites W2043593402 @default.
• W4377011480 cites W2089224859 @default.
• W4377011480 cites W2089905323 @default.
• W4377011480 cites W2137330150 @default.
• W4377011480 cites W2165456770 @default.
• W4377011480 cites W2185075416 @default.
• W4377011480 cites W2317340981 @default.
• W4377011480 cites W2527905628 @default.
• W4377011480 cites W2582320162 @default.
• W4377011480 cites W2592389792 @default.
• W4377011480 cites W2765314233 @default.
• W4377011480 cites W2766903152 @default.
• W4377011480 cites W2782333299 @default.
• W4377011480 cites W2782401411 @default.
• W4377011480 cites W2791043965 @default.
• W4377011480 cites W2794616539 @default.
• W4377011480 cites W2801806358 @default.
• W4377011480 cites W2811099396 @default.
• W4377011480 cites W2889326414 @default.
• W4377011480 cites W2909988858 @default.
• W4377011480 cites W2942123458 @default.
• W4377011480 cites W2972674410 @default.
• W4377011480 cites W2979785336 @default.
• W4377011480 cites W2990618091 @default.
• W4377011480 cites W3011129791 @default.
• W4377011480 cites W3021579311 @default.
• W4377011480 cites W3023926528 @default.
• W4377011480 cites W3081548621 @default.
• W4377011480 cites W3106917142 @default.
• W4377011480 cites W3110296131 @default.
• W4377011480 cites W3140133734 @default.
• W4377011480 cites W3144440532 @default.
• W4377011480 cites W3164027315 @default.
• W4377011480 cites W3164167181 @default.
• W4377011480 cites W3203871262 @default.
• W4377011480 cites W4200173600 @default.
• W4377011480 cites W4200411876 @default.
• W4377011480 cites W4210394199 @default.
• W4377011480 cites W4224272306 @default.
• W4377011480 cites W4226426960 @default.
• W4377011480 cites W4283662269 @default.
• W4377011480 cites W4285611072 @default.
• W4377011480 cites W4291397340 @default.
• W4377011480 doi "https://doi.org/10.1080/2162402x.2023.2204746" @default.
• W4377011480 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37197440" @default.
• W4377011480 hasPublicationYear "2023" @default.
• W4377011480 type Work @default.
• W4377011480 citedByCount "1" @default.
• W4377011480 countsByYear W43770114802023 @default.
• W4377011480 crossrefType "journal-article" @default.
• W4377011480 hasAuthorship W4377011480A5006056998 @default.
• W4377011480 hasAuthorship W4377011480A5010484767 @default.
• W4377011480 hasAuthorship W4377011480A5010575961 @default.
• W4377011480 hasAuthorship W4377011480A5020220994 @default.
• W4377011480 hasAuthorship W4377011480A5030361070 @default.
• W4377011480 hasAuthorship W4377011480A5041499764 @default.
• W4377011480 hasAuthorship W4377011480A5047899806 @default.
• W4377011480 hasAuthorship W4377011480A5057244028 @default.
• W4377011480 hasAuthorship W4377011480A5066209110 @default.
• W4377011480 hasAuthorship W4377011480A5066457628 @default.
• W4377011480 hasAuthorship W4377011480A5069675443 @default.
• W4377011480 hasAuthorship W4377011480A5080669646 @default.
• W4377011480 hasBestOaLocation W43770114801 @default.
• W4377011480 hasConcept C126322002 @default.
• W4377011480 hasConcept C143998085 @default.
• W4377011480 hasConcept C203014093 @default.
• W4377011480 hasConcept C2776256026 @default.
• W4377011480 hasConcept C2776694085 @default.
• W4377011480 hasConcept C2780739268 @default.
• W4377011480 hasConcept C50382708 @default.
• W4377011480 hasConcept C71924100 @default.
• W4377011480 hasConcept C86803240 @default.
• W4377011480 hasConceptScore W4377011480C126322002 @default.
• W4377011480 hasConceptScore W4377011480C143998085 @default.
• W4377011480 hasConceptScore W4377011480C203014093 @default.
• W4377011480 hasConceptScore W4377011480C2776256026 @default.
• W4377011480 hasConceptScore W4377011480C2776694085 @default.
• W4377011480 hasConceptScore W4377011480C2780739268 @default.
• W4377011480 hasConceptScore W4377011480C50382708 @default.
• W4377011480 hasConceptScore W4377011480C71924100 @default.
• W4377011480 hasConceptScore W4377011480C86803240 @default.
• W4377011480 hasIssue "1" @default.

• next