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- W4377011632 abstract "Asymmetric intermolecular C–H functionalization of pyridines at C3 is unprecedented. Herein, we report the first examples of such transformations: specifically, C3-allylation of pyridines via tandem borane and iridium catalysis. First, borane-catalyzed pyridine hydroboration generates nucleophilic dihydropyridines; then, the dihydropyridine undergoes enantioselective iridium-catalyzed allylation; and finally, oxidative aromatization with air as the oxidant gives the C3-allylated pyridine. This protocol provides direct access to C3-allylated pyridines with excellent enantioselectivity (up to >99% ee) and is suitable for late-stage functionalization of pyridine-containing drugs." @default.
- W4377011632 created "2023-05-19" @default.
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- W4377011632 date "2023-05-18" @default.
- W4377011632 modified "2023-10-17" @default.
- W4377011632 title "Asymmetric C3-Allylation of Pyridines" @default.
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- W4377011632 doi "https://doi.org/10.1021/jacs.3c03056" @default.
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