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• W4377011636 abstract "Abstract Background Numerous studies have shown that the insulin‐like growth factor (IGF) pathway is highly associated with tumor initial and progression in several tumors. However, compared with IGF1/1R and IGF2/2R, insufficient studies have focused on IGF‐binding proteins (IGFBPs). Methods The GDC TCGA and GTEx data of 33 cancers, TCGA pan‐cancer immune phenotypes, tumor mutation burdens, and the copy number alterations of IGFBPs were extracted. Next, the prognostic value of IGFBPs was analyzed based on a univariate Cox analysis. Additionally, the ESTIMATE algorithm was used to calculate stromal and immune scores and tumor purity, and the CIBERSORT algorithm was used to estimate tumor‐infiltrating immunocyte levels. Ultimately, the correlation between IGFBP expression and cancer hallmark pathways was estimated with a Spearman analysis. Results The expression of IGFBPs was differentially expressed and correlated with prognosis in specific cancers. IGFBPs may operate as biological markers for carcinogenesis and progression and as prognostic biomarkers. Additionally, IGFBP5 has been proved that promotes the invasion and migration of ovarian cancer. Conclusions In general, IGFBPs can serve as predictable biomarkers and potential therapeutic targets for specific tumors. Our results could provide underlying targets for the design of laboratory experiments to elucidate the mechanism of IGFBPs in cancers and identify IGFBP5 as a prognostic factor in ovarian cancers." @default.
• W4377011636 created "2023-05-19" @default.
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• W4377011636 date "2023-05-18" @default.
• W4377011636 modified "2023-10-17" @default.
• W4377011636 title "Pan‐cancer analysis of oncogenic role of insulin‐like growth factor‐binding proteins and validation in ovarian cancer" @default.
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• W4377011636 cites W2062565310 @default.
• W4377011636 cites W2070923004 @default.
• W4377011636 cites W2074076323 @default.
• W4377011636 cites W2080023722 @default.
• W4377011636 cites W2117692326 @default.
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• W4377011636 doi "https://doi.org/10.1002/cam4.6073" @default.
• W4377011636 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37199034" @default.
• W4377011636 hasPublicationYear "2023" @default.
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