Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377011662> ?p ?o ?g. }
- W4377011662 abstract "Development of miniaturized lab-on-chip devices for the detection of rapid and specific small molecule-protein binding interactions at very low concentrations holds significant importance in drug discovery and biomedical applications. Here, the label-free detection of small molecule-protein interactions is reported on the surface functionalizable nanotubes of α,γ-hybrid peptide helical foldamers using nanoscale capacitance and impedance spectroscopy. The 12-helix conformation of the α,γ-hybrid peptide observed in the single crystals, self-assembled into nanotubes in an aqueous environment with exposed cysteine thiols for small molecule conjugation. The binding of streptavidin to the covalently linked biotin on the surface of nanotubes was detected at the picomolar concentrations. No change in the capacitance and impedance were observed in the absence of either immobilized biotin or protein streptavidin. The functionalizable hybrid peptide nanotubes reported here pave the way for the label-free detection of various small molecule protein interactions at very low concentrations." @default.
- W4377011662 created "2023-05-19" @default.
- W4377011662 creator A5019861460 @default.
- W4377011662 creator A5045038164 @default.
- W4377011662 creator A5059662674 @default.
- W4377011662 creator A5064424304 @default.
- W4377011662 creator A5068294648 @default.
- W4377011662 creator A5071823137 @default.
- W4377011662 creator A5080173725 @default.
- W4377011662 creator A5083636083 @default.
- W4377011662 date "2023-06-23" @default.
- W4377011662 modified "2023-10-17" @default.
- W4377011662 title "Foldamer Nanotubes Mediated Label‐Free Detection of Protein‐Small Molecule Interactions" @default.
- W4377011662 cites W1155787917 @default.
- W4377011662 cites W1967703178 @default.
- W4377011662 cites W1969114020 @default.
- W4377011662 cites W1973131581 @default.
- W4377011662 cites W1978755559 @default.
- W4377011662 cites W1983955924 @default.
- W4377011662 cites W1988531810 @default.
- W4377011662 cites W1994651691 @default.
- W4377011662 cites W2004914821 @default.
- W4377011662 cites W2008307658 @default.
- W4377011662 cites W2026313962 @default.
- W4377011662 cites W2048649981 @default.
- W4377011662 cites W2048791537 @default.
- W4377011662 cites W2049725266 @default.
- W4377011662 cites W2053656537 @default.
- W4377011662 cites W2063060911 @default.
- W4377011662 cites W2069507241 @default.
- W4377011662 cites W2092139560 @default.
- W4377011662 cites W2096345551 @default.
- W4377011662 cites W2099684865 @default.
- W4377011662 cites W2106493017 @default.
- W4377011662 cites W2107290421 @default.
- W4377011662 cites W2108720036 @default.
- W4377011662 cites W2109573858 @default.
- W4377011662 cites W2113469181 @default.
- W4377011662 cites W2115792147 @default.
- W4377011662 cites W2117611627 @default.
- W4377011662 cites W2120028914 @default.
- W4377011662 cites W2123852384 @default.
- W4377011662 cites W2148472046 @default.
- W4377011662 cites W2150382188 @default.
- W4377011662 cites W2164518416 @default.
- W4377011662 cites W2273789836 @default.
- W4377011662 cites W2322972210 @default.
- W4377011662 cites W2331358455 @default.
- W4377011662 cites W2333981708 @default.
- W4377011662 cites W2338346959 @default.
- W4377011662 cites W2412136252 @default.
- W4377011662 cites W2414778593 @default.
- W4377011662 cites W2469976997 @default.
- W4377011662 cites W2768678455 @default.
- W4377011662 cites W2769617661 @default.
- W4377011662 cites W2790532659 @default.
- W4377011662 cites W2794880010 @default.
- W4377011662 cites W2800204951 @default.
- W4377011662 cites W2804957616 @default.
- W4377011662 cites W2885602609 @default.
- W4377011662 cites W2901993470 @default.
- W4377011662 cites W3025214485 @default.
- W4377011662 cites W3087949815 @default.
- W4377011662 cites W3114791058 @default.
- W4377011662 cites W3125585717 @default.
- W4377011662 cites W3129123370 @default.
- W4377011662 cites W3163823919 @default.
- W4377011662 cites W3194556653 @default.
- W4377011662 cites W3204254871 @default.
- W4377011662 cites W3209576331 @default.
- W4377011662 cites W4210543086 @default.
- W4377011662 cites W4211214045 @default.
- W4377011662 cites W4211235262 @default.
- W4377011662 cites W4230117297 @default.
- W4377011662 cites W4230321861 @default.
- W4377011662 cites W4236463781 @default.
- W4377011662 cites W4236521750 @default.
- W4377011662 cites W4245399232 @default.
- W4377011662 cites W4246705774 @default.
- W4377011662 cites W4248737905 @default.
- W4377011662 cites W4250532152 @default.
- W4377011662 cites W4254496810 @default.
- W4377011662 cites W4256055330 @default.
- W4377011662 doi "https://doi.org/10.1002/chem.202300479" @default.
- W4377011662 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37199015" @default.
- W4377011662 hasPublicationYear "2023" @default.
- W4377011662 type Work @default.
- W4377011662 citedByCount "0" @default.
- W4377011662 crossrefType "journal-article" @default.
- W4377011662 hasAuthorship W4377011662A5019861460 @default.
- W4377011662 hasAuthorship W4377011662A5045038164 @default.
- W4377011662 hasAuthorship W4377011662A5059662674 @default.
- W4377011662 hasAuthorship W4377011662A5064424304 @default.
- W4377011662 hasAuthorship W4377011662A5068294648 @default.
- W4377011662 hasAuthorship W4377011662A5071823137 @default.
- W4377011662 hasAuthorship W4377011662A5080173725 @default.
- W4377011662 hasAuthorship W4377011662A5083636083 @default.
- W4377011662 hasConcept C12554922 @default.
- W4377011662 hasConcept C160756335 @default.
- W4377011662 hasConcept C161624437 @default.