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- W4377011664 abstract "Peptides with the ability to self-assemble into nanoparticles have emerged as an attractive strategy to design antigen delivery platforms for subunit vaccines. While toll-like receptor (TLR) agonists are promising immunostimulants, their use as soluble agents is limited by their rapid clearance and off-target inflammation. Herein, we harnessed molecular co-assembly to prepare multicomponent cross-β-sheet peptide nanofilaments exposing an antigenic epitope derived from the influenza A virus and a TLR agonist. The TLR7 agonist imiquimod and the TLR9 agonist CpG were respectively functionalized on the assemblies by means of an orthogonal pre- or post-assembly conjugation strategy. The nanofilaments were readily uptaken by dendritic cells, and the TLR agonists retained their activity. Multicomponent nanovaccines induced a robust epitope-specific immune response and completely protected immunized mice from a lethal influenza A virus inoculation. This versatile bottom-up approach is promising for the preparation of synthetic vaccines with customized magnitude and polarization of the immune responses." @default.
- W4377011664 created "2023-05-19" @default.
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- W4377011664 date "2023-05-18" @default.
- W4377011664 modified "2023-09-30" @default.
- W4377011664 title "Synthetic Multicomponent Nanovaccines Based on the Molecular Co-assembly of β-Peptides Protect against Influenza A Virus" @default.
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- W4377011664 doi "https://doi.org/10.1021/acsinfecdis.2c00610" @default.
- W4377011664 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37200051" @default.
- W4377011664 hasPublicationYear "2023" @default.
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