FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377011702> ?p ?o ?g. }

• W4377011702 abstract "MALDI-TOF MS is considered to be an important tool for the future development of rapid microbiological techniques. We propose the application of MALDI-TOF MS as a dual technique for the identification of bacteria and the detection of resistance, with no extra hands-on procedures. We have developed a machine learning approach that uses the random forest algorithm for the direct prediction of carbapenemase-producing Klebsiella pneumoniae (CPK) isolates, based on the spectra of complete cells. For this purpose, we used a database of 4,547 mass spectra profiles, including 715 unduplicated clinical isolates that are represented by 324 CPK with 37 different ST. The impact of the culture medium was determinant in the CPK prediction, being that the isolates were tested and cultured in the same media, compared to the isolates used to build the model (blood agar). The proposed method has an accuracy of 97.83% for the prediction of CPK and an accuracy of 95.24% for the prediction of OXA-48 or KPC carriage. For the CPK prediction, the RF algorithm yielded a value of 1.00 for both the area under the receiver operating characteristic curve and the area under the precision-recall curve. The contribution of individual mass peaks to the CPK prediction was determined using Shapley values, which revealed that the complete proteome, rather than a series of mass peaks or potential biomarkers (as previously suggested), is responsible for the algorithm-based classification. Thus, the use of the full spectrum, as proposed here, with a pattern-matching analytical algorithm produced the best outcome. The use of MALDI-TOF MS coupled with machine learning algorithm processing enabled the identification of CPK isolates within only a few minutes, thereby reducing the time to detection of resistance." @default.
• W4377011702 created "2023-05-19" @default.
• W4377011702 creator A5002129035 @default.
• W4377011702 creator A5013741181 @default.
• W4377011702 creator A5025886706 @default.
• W4377011702 creator A5044676398 @default.
• W4377011702 creator A5045208507 @default.
• W4377011702 creator A5049610126 @default.
• W4377011702 creator A5071344263 @default.
• W4377011702 creator A5073240026 @default.
• W4377011702 creator A5074485232 @default.
• W4377011702 creator A5077363384 @default.
• W4377011702 creator A5079090385 @default.
• W4377011702 creator A5082548129 @default.
• W4377011702 date "2023-06-20" @default.
• W4377011702 modified "2023-10-16" @default.
• W4377011702 title "Direct Detection of Carbapenemase-Producing Klebsiella pneumoniae by MALDI-TOF Analysis of Full Spectra Applying Machine Learning" @default.
• W4377011702 cites W1714712325 @default.
• W4377011702 cites W1830515907 @default.
• W4377011702 cites W1966976587 @default.
• W4377011702 cites W1972895220 @default.
• W4377011702 cites W1983023275 @default.
• W4377011702 cites W2024237409 @default.
• W4377011702 cites W2025833196 @default.
• W4377011702 cites W2048218193 @default.
• W4377011702 cites W2065337857 @default.
• W4377011702 cites W2096093282 @default.
• W4377011702 cites W2134852597 @default.
• W4377011702 cites W2137683650 @default.
• W4377011702 cites W2153325555 @default.
• W4377011702 cites W2155860425 @default.
• W4377011702 cites W2402601207 @default.
• W4377011702 cites W2578718824 @default.
• W4377011702 cites W2691524510 @default.
• W4377011702 cites W2770310499 @default.
• W4377011702 cites W2778455075 @default.
• W4377011702 cites W2786886659 @default.
• W4377011702 cites W2807534664 @default.
• W4377011702 cites W2899841051 @default.
• W4377011702 cites W2903295599 @default.
• W4377011702 cites W2952167528 @default.
• W4377011702 cites W2987249562 @default.
• W4377011702 cites W2991119923 @default.
• W4377011702 cites W3000720825 @default.
• W4377011702 cites W3048915008 @default.
• W4377011702 cites W3135004288 @default.
• W4377011702 cites W3159164036 @default.
• W4377011702 cites W3162370580 @default.
• W4377011702 cites W4210264209 @default.
• W4377011702 cites W4226263987 @default.
• W4377011702 cites W4226275940 @default.
• W4377011702 cites W4291954679 @default.
• W4377011702 cites W4294214983 @default.
• W4377011702 doi "https://doi.org/10.1128/jcm.01751-22" @default.
• W4377011702 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37199638" @default.
• W4377011702 hasPublicationYear "2023" @default.
• W4377011702 type Work @default.
• W4377011702 citedByCount "2" @default.
• W4377011702 countsByYear W43770117022023 @default.
• W4377011702 crossrefType "journal-article" @default.
• W4377011702 hasAuthorship W4377011702A5002129035 @default.
• W4377011702 hasAuthorship W4377011702A5013741181 @default.
• W4377011702 hasAuthorship W4377011702A5025886706 @default.
• W4377011702 hasAuthorship W4377011702A5044676398 @default.
• W4377011702 hasAuthorship W4377011702A5045208507 @default.
• W4377011702 hasAuthorship W4377011702A5049610126 @default.
• W4377011702 hasAuthorship W4377011702A5071344263 @default.
• W4377011702 hasAuthorship W4377011702A5073240026 @default.
• W4377011702 hasAuthorship W4377011702A5074485232 @default.
• W4377011702 hasAuthorship W4377011702A5077363384 @default.
• W4377011702 hasAuthorship W4377011702A5079090385 @default.
• W4377011702 hasAuthorship W4377011702A5082548129 @default.
• W4377011702 hasBestOaLocation W43770117021 @default.
• W4377011702 hasConcept C104317684 @default.
• W4377011702 hasConcept C116834253 @default.
• W4377011702 hasConcept C119857082 @default.
• W4377011702 hasConcept C154945302 @default.
• W4377011702 hasConcept C162356407 @default.
• W4377011702 hasConcept C185592680 @default.
• W4377011702 hasConcept C2777058267 @default.
• W4377011702 hasConcept C2779116282 @default.
• W4377011702 hasConcept C2992965680 @default.
• W4377011702 hasConcept C40325409 @default.
• W4377011702 hasConcept C41008148 @default.
• W4377011702 hasConcept C43617362 @default.
• W4377011702 hasConcept C54355233 @default.
• W4377011702 hasConcept C547475151 @default.
• W4377011702 hasConcept C58471807 @default.
• W4377011702 hasConcept C59822182 @default.
• W4377011702 hasConcept C70721500 @default.
• W4377011702 hasConcept C86803240 @default.
• W4377011702 hasConcept C89423630 @default.
• W4377011702 hasConceptScore W4377011702C104317684 @default.
• W4377011702 hasConceptScore W4377011702C116834253 @default.
• W4377011702 hasConceptScore W4377011702C119857082 @default.
• W4377011702 hasConceptScore W4377011702C154945302 @default.
• W4377011702 hasConceptScore W4377011702C162356407 @default.
• W4377011702 hasConceptScore W4377011702C185592680 @default.
• W4377011702 hasConceptScore W4377011702C2777058267 @default.
• W4377011702 hasConceptScore W4377011702C2779116282 @default.

• next