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- W4377011783 abstract "Therapeutic antibodies selectively targeting EPHA2 with or without co-targeting another receptor tyrosine kinase have been limited to date. By integrating state-of-art proteogenomic, ex vivo models, and short hairpin RNA screening approaches, a new designing strategy has now discovered a bispecific therapeutic antibody co-targeting EPHA2 and EGFR - which effectively inhibits tumor cell growth in various preclinical cancer models. This new antibody provides new tools to impair the acquired resistance to EGFR-directed therapies or co-target EPHA2 and EGFR in human tumor. See related article by El Zawily et al., p. 2686." @default.
- W4377011783 created "2023-05-19" @default.
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- W4377011783 date "2023-05-18" @default.
- W4377011783 modified "2023-09-27" @default.
- W4377011783 title "A Designer Strategy to Develop Novel Bispecific Cancer Therapeutic Antibodies" @default.
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- W4377011783 doi "https://doi.org/10.1158/1078-0432.ccr-23-0737" @default.
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