FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377011787> ?p ?o ?g. }

• W4377011787 abstract "Background: The clinical outcomes of busulfan-based conditioning regimens for hematopoietic cell transplantation (HCT) have been improved by personalizing the doses to target narrow busulfan plasma exposure. An interlaboratory proficiency test program for the quantitation, pharmacokinetic modeling, and busulfan dosing in plasma was developed. Previous proficiency rounds (ie, the first 2) found that 67%–85% and 71%–88% of the dose recommendations were inaccurate, respectively. Methods: A proficiency test scheme was developed by the Dutch Foundation for Quality Assessment in Medical Laboratories (SKML) and consisted of 2 rounds per year, with each round containing 2 busulfan samples. In this study, 5 subsequent proficiency tests were evaluated. In each round, the participating laboratories reported their results for 2 proficiency samples (ie, low and high busulfan concentrations) and a theoretical case assessing their pharmacokinetic modeling and dose recommendations. Descriptive statistics were performed, with ±15% for busulfan concentrations and ±10% for busulfan plasma exposure. The dose recommendations were deemed accurate. Results: Since January 2020, 41 laboratories have participated in at least 1 round of this proficiency test. Over the 5 rounds, an average of 78% of the busulfan concentrations were accurate. Area under the concentration–time curve calculations were accurate in 75%–80% of the cases, whereas only 60%–69% of the dose recommendations were accurate. Compared with the first 2 proficiency test rounds (PMID 33675302, October, 2021), the busulfan quantitation results were similar, but the dose recommendations worsened. Some laboratories repeatedly submit results that deviated by more than 15% from the reference values. Conclusions: The proficiency test showed persistent inaccuracies in busulfan quantitation, pharmacokinetic modeling, and dose recommendations. Additional educational efforts have yet to be implemented; regulatory efforts seem to be needed. The use of specialized busulfan pharmacokinetic laboratories or a sufficient performance in busulfan proficiency tests should be required for HCT centers that prescribe busulfan." @default.
• W4377011787 created "2023-05-19" @default.
• W4377011787 creator A5010186562 @default.
• W4377011787 creator A5024123937 @default.
• W4377011787 creator A5063903295 @default.
• W4377011787 creator A5064388673 @default.
• W4377011787 creator A5073189722 @default.
• W4377011787 date "2023-05-12" @default.
• W4377011787 modified "2023-10-14" @default.
• W4377011787 title "Busulfan Interlaboratory Proficiency Testing Program Revealed Worldwide Errors in Drug Quantitation and Dose Recommendations" @default.
• W4377011787 cites W1976623989 @default.
• W4377011787 cites W1992485317 @default.
• W4377011787 cites W1997472326 @default.
• W4377011787 cites W2009686578 @default.
• W4377011787 cites W2079167213 @default.
• W4377011787 cites W2091488701 @default.
• W4377011787 cites W2092982405 @default.
• W4377011787 cites W2093328665 @default.
• W4377011787 cites W2135415429 @default.
• W4377011787 cites W2276362528 @default.
• W4377011787 cites W2334769895 @default.
• W4377011787 cites W2487244003 @default.
• W4377011787 cites W2530375062 @default.
• W4377011787 cites W2770919014 @default.
• W4377011787 cites W3094292602 @default.
• W4377011787 cites W3133530351 @default.
• W4377011787 cites W4225252963 @default.
• W4377011787 doi "https://doi.org/10.1097/ftd.0000000000001107" @default.
• W4377011787 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37199431" @default.
• W4377011787 hasPublicationYear "2023" @default.
• W4377011787 type Work @default.
• W4377011787 citedByCount "0" @default.
• W4377011787 crossrefType "journal-article" @default.
• W4377011787 hasAuthorship W4377011787A5010186562 @default.
• W4377011787 hasAuthorship W4377011787A5024123937 @default.
• W4377011787 hasAuthorship W4377011787A5063903295 @default.
• W4377011787 hasAuthorship W4377011787A5064388673 @default.
• W4377011787 hasAuthorship W4377011787A5073189722 @default.
• W4377011787 hasBestOaLocation W43770117871 @default.
• W4377011787 hasConcept C112705442 @default.
• W4377011787 hasConcept C126322002 @default.
• W4377011787 hasConcept C19527891 @default.
• W4377011787 hasConcept C2777288759 @default.
• W4377011787 hasConcept C2777408962 @default.
• W4377011787 hasConcept C2780272996 @default.
• W4377011787 hasConcept C2780611847 @default.
• W4377011787 hasConcept C2911091166 @default.
• W4377011787 hasConcept C71924100 @default.
• W4377011787 hasConcept C98274493 @default.
• W4377011787 hasConceptScore W4377011787C112705442 @default.
• W4377011787 hasConceptScore W4377011787C126322002 @default.
• W4377011787 hasConceptScore W4377011787C19527891 @default.
• W4377011787 hasConceptScore W4377011787C2777288759 @default.
• W4377011787 hasConceptScore W4377011787C2777408962 @default.
• W4377011787 hasConceptScore W4377011787C2780272996 @default.
• W4377011787 hasConceptScore W4377011787C2780611847 @default.
• W4377011787 hasConceptScore W4377011787C2911091166 @default.
• W4377011787 hasConceptScore W4377011787C71924100 @default.
• W4377011787 hasConceptScore W4377011787C98274493 @default.
• W4377011787 hasLocation W43770117871 @default.
• W4377011787 hasLocation W43770117872 @default.
• W4377011787 hasLocation W43770117873 @default.
• W4377011787 hasOpenAccess W4377011787 @default.
• W4377011787 hasPrimaryLocation W43770117871 @default.
• W4377011787 hasRelatedWork W2078389671 @default.
• W4377011787 hasRelatedWork W2093607596 @default.
• W4377011787 hasRelatedWork W2112746033 @default.
• W4377011787 hasRelatedWork W2255597018 @default.
• W4377011787 hasRelatedWork W2420918848 @default.
• W4377011787 hasRelatedWork W2562474475 @default.
• W4377011787 hasRelatedWork W2600486518 @default.
• W4377011787 hasRelatedWork W2604785062 @default.
• W4377011787 hasRelatedWork W2901966018 @default.
• W4377011787 hasRelatedWork W4319598469 @default.
• W4377011787 hasVolume "Publish Ahead of Print" @default.
• W4377011787 isParatext "false" @default.
• W4377011787 isRetracted "false" @default.
• W4377011787 workType "article" @default.