FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377011803> ?p ?o ?g. }

• W4377011803 endingPage "1644" @default.
• W4377011803 startingPage "1637" @default.
• W4377011803 abstract "Paroxysmal nocturnal hemoglobinuria (PNH) is caused by acquired gene mutations resulting in deficiency of glycosylphosphatidylinositol (GPI)-anchored complement regulatory proteins on the surface of blood cells, leading to terminal complement-mediated intravascular hemolysis and increased risk of major adverse vascular events (MAVEs). Using data from the International PNH Registry, this study investigated the relationship between the proportion of GPI-deficient granulocytes at PNH onset and (1) the risk for MAVEs (including thrombotic events [TEs]) and (2) the following parameters at last follow-up: high disease activity (HDA); lactate dehydrogenase (LDH) ratio; fatigue; abdominal pain; and rates of overall MAVEs and TEs. A total of 2813 patients untreated at enrollment were included and stratified by clone size at PNH disease onset (baseline). At last follow-up, higher proportion of GPI-deficient granulocytes (≤ 5% vs. > 30% clone size) at baseline was associated with significantly increased HDA incidence (14% vs. 77%), mean LDH ratio (1.3 vs. 4.7 × upper limit of normal), and rates of MAVEs 1.5 vs. 2.9 per 100 person-years) and TEs (0.9 vs. 2.0 per 100 person-years). Fatigue was evident in 71 to 76% of patients regardless of clone size. Abdominal pain was more frequently reported with clone size > 30%. A larger clone size at baseline appears to indicate a greater disease burden and risk of TEs and MAVEs and may inform decision making among physicians managing PNH patients at risk of experiencing TEs or other MAVEs. ClinicalTrials.gov ID: NCT01374360." @default.
• W4377011803 created "2023-05-19" @default.
• W4377011803 creator A5001705277 @default.
• W4377011803 creator A5007747233 @default.
• W4377011803 creator A5009473954 @default.
• W4377011803 creator A5027516224 @default.
• W4377011803 creator A5028285126 @default.
• W4377011803 creator A5029802364 @default.
• W4377011803 creator A5068820436 @default.
• W4377011803 creator A5085974329 @default.
• W4377011803 date "2023-05-18" @default.
• W4377011803 modified "2023-10-18" @default.
• W4377011803 title "Relationship of paroxysmal nocturnal hemoglobinuria (PNH) granulocyte clone size to disease burden and risk of major vascular events in untreated patients: results from the International PNH Registry" @default.
• W4377011803 cites W1969649853 @default.
• W4377011803 cites W1970244706 @default.
• W4377011803 cites W1970972261 @default.
• W4377011803 cites W1985084429 @default.
• W4377011803 cites W2015258163 @default.
• W4377011803 cites W2037350984 @default.
• W4377011803 cites W2081978633 @default.
• W4377011803 cites W2134914390 @default.
• W4377011803 cites W2160184317 @default.
• W4377011803 cites W2163541746 @default.
• W4377011803 cites W2340165058 @default.
• W4377011803 cites W2427944740 @default.
• W4377011803 cites W2893654740 @default.
• W4377011803 cites W2971095077 @default.
• W4377011803 cites W2985220877 @default.
• W4377011803 cites W3022268070 @default.
• W4377011803 cites W3027703680 @default.
• W4377011803 cites W3164044269 @default.
• W4377011803 doi "https://doi.org/10.1007/s00277-023-05269-4" @default.
• W4377011803 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37199789" @default.
• W4377011803 hasPublicationYear "2023" @default.
• W4377011803 type Work @default.
• W4377011803 citedByCount "0" @default.
• W4377011803 crossrefType "journal-article" @default.
• W4377011803 hasAuthorship W4377011803A5001705277 @default.
• W4377011803 hasAuthorship W4377011803A5007747233 @default.
• W4377011803 hasAuthorship W4377011803A5009473954 @default.
• W4377011803 hasAuthorship W4377011803A5027516224 @default.
• W4377011803 hasAuthorship W4377011803A5028285126 @default.
• W4377011803 hasAuthorship W4377011803A5029802364 @default.
• W4377011803 hasAuthorship W4377011803A5068820436 @default.
• W4377011803 hasAuthorship W4377011803A5085974329 @default.
• W4377011803 hasBestOaLocation W43770118031 @default.
• W4377011803 hasConcept C111684460 @default.
• W4377011803 hasConcept C126322002 @default.
• W4377011803 hasConcept C159654299 @default.
• W4377011803 hasConcept C181199279 @default.
• W4377011803 hasConcept C184404459 @default.
• W4377011803 hasConcept C194409129 @default.
• W4377011803 hasConcept C203014093 @default.
• W4377011803 hasConcept C2777318727 @default.
• W4377011803 hasConcept C2777346216 @default.
• W4377011803 hasConcept C2777991916 @default.
• W4377011803 hasConcept C2778639011 @default.
• W4377011803 hasConcept C2779902561 @default.
• W4377011803 hasConcept C54355233 @default.
• W4377011803 hasConcept C552990157 @default.
• W4377011803 hasConcept C55493867 @default.
• W4377011803 hasConcept C71924100 @default.
• W4377011803 hasConcept C81089528 @default.
• W4377011803 hasConcept C86803240 @default.
• W4377011803 hasConcept C90924648 @default.
• W4377011803 hasConceptScore W4377011803C111684460 @default.
• W4377011803 hasConceptScore W4377011803C126322002 @default.
• W4377011803 hasConceptScore W4377011803C159654299 @default.
• W4377011803 hasConceptScore W4377011803C181199279 @default.
• W4377011803 hasConceptScore W4377011803C184404459 @default.
• W4377011803 hasConceptScore W4377011803C194409129 @default.
• W4377011803 hasConceptScore W4377011803C203014093 @default.
• W4377011803 hasConceptScore W4377011803C2777318727 @default.
• W4377011803 hasConceptScore W4377011803C2777346216 @default.
• W4377011803 hasConceptScore W4377011803C2777991916 @default.
• W4377011803 hasConceptScore W4377011803C2778639011 @default.
• W4377011803 hasConceptScore W4377011803C2779902561 @default.
• W4377011803 hasConceptScore W4377011803C54355233 @default.
• W4377011803 hasConceptScore W4377011803C552990157 @default.
• W4377011803 hasConceptScore W4377011803C55493867 @default.
• W4377011803 hasConceptScore W4377011803C71924100 @default.
• W4377011803 hasConceptScore W4377011803C81089528 @default.
• W4377011803 hasConceptScore W4377011803C86803240 @default.
• W4377011803 hasConceptScore W4377011803C90924648 @default.
• W4377011803 hasIssue "7" @default.
• W4377011803 hasLocation W43770118031 @default.
• W4377011803 hasLocation W43770118032 @default.
• W4377011803 hasOpenAccess W4377011803 @default.
• W4377011803 hasPrimaryLocation W43770118031 @default.
• W4377011803 hasRelatedWork W1993185906 @default.
• W4377011803 hasRelatedWork W2004708426 @default.
• W4377011803 hasRelatedWork W2014076819 @default.
• W4377011803 hasRelatedWork W2044079477 @default.
• W4377011803 hasRelatedWork W2081653014 @default.
• W4377011803 hasRelatedWork W2365492223 @default.
• W4377011803 hasRelatedWork W2508092820 @default.
• W4377011803 hasRelatedWork W2580129952 @default.
• W4377011803 hasRelatedWork W2993389739 @default.

• next