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• W4377011829 startingPage "1320" @default.
• W4377011829 abstract "Breast milk contains constituents, such as 1,3-dioleoyl-2-palmitoylglycerol (OPO), that are beneficial for infants. Herein, we hypothesized that 2-palmitoyl glycerol (2-PG), a derivative of OPO, is advantageous to infants' development. Gamma aminobutyric acid (GABA) is a major neurotransmitter involved in neural development. Although GABA is generally known to be produced in neurons, astrocytes can also produce it in immature brains. In this study, we used expression analysis techniques to show that 2-PG upregulates the mRNA and protein expression of glutamate decarboxylases (GAD1 and GAD2) in normal human fetal-derived astrocytes. Our data suggest that 2-PG promotes GABA synthesis in astrocytes, which may contribute to brain development because GABA is involved in neural development in the developing brain. This may help to elucidate the mechanism by which breast milk affects infant brain development." @default.
• W4377011829 created "2023-05-19" @default.
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• W4377011829 date "2023-05-24" @default.
• W4377011829 modified "2023-09-30" @default.
• W4377011829 title "Direct effect of 2‐palmitoyl glycerol on promotion of gamma aminobutyric acid synthesis in normal human fetal‐derived astrocytes" @default.
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• W4377011829 doi "https://doi.org/10.1002/2211-5463.13649" @default.
• W4377011829 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37199045" @default.
• W4377011829 hasPublicationYear "2023" @default.
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