FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377011856> ?p ?o ?g. }

• W4377011856 endingPage "201" @default.
• W4377011856 startingPage "193" @default.
• W4377011856 abstract "Abstract SpikoGen® vaccine is a subunit COVID‐19 vaccine expressed in insect cells comprising recombinant spike protein extracellular domain formulated with Advax‐CpG55.2™ adjuvant. A Phase 2 trial was conducted in 400 adult participants randomised 3:1 to receive two intramuscular doses of SpikoGen® vaccine or saline placebo 3 weeks apart. Some Phase 2 trial participants later enrolled in a separate booster study and received a third dose of SpikoGen® vaccine. This stored serum was used to assess the ability of SpikoGen® vaccine to induce cross‐neutralising antibodies against SARS‐CoV‐2 variants of concern. Sera taken at baseline and 2 weeks after the second vaccine dose from baseline seronegative Phase 2 subjects was evaluated using a panel of spike pseudotype lentivirus neutralisation assays for the ability to cross‐neutralise a wide range of SARS‐CoV‐2 variants, including Omicron BA.1, BA.2 and BA.4/5. Stored samples of subjects who participated in both the 2‐dose Phase 2 trial and a third dose booster trial 6 months later were also analysed for changes in cross‐neutralising antibodies over time and dose. Two weeks after the second dose, sera broadly cross‐neutralised most variants of concern, albeit with titres against Omicron variants being ~10‐fold lower. While Omicron titres fell to low levels 6 months after the second vaccine dose in most subjects, they showed a ~20‐fold rise after the third dose booster, after which there was only a ~2‐3‐fold difference in neutralisation of Omicron and the ancestral strains. Despite being based on the ancestral Wuhan sequence, after two doses, SpikoGen® vaccine induced broadly cross‐neutralising serum antibodies. Titres then reduced over time but were rapidly restored by a third dose booster. This resulted in high neutralisation including against the Omicron variants. This data supports ongoing use of SpikoGen® vaccine for protection against recent SARS‐CoV‐2 Omicron variants." @default.
• W4377011856 created "2023-05-19" @default.
• W4377011856 creator A5012651782 @default.
• W4377011856 creator A5014163577 @default.
• W4377011856 creator A5048011861 @default.
• W4377011856 creator A5061251507 @default.
• W4377011856 creator A5070788647 @default.
• W4377011856 creator A5079311523 @default.
• W4377011856 date "2023-05-18" @default.
• W4377011856 modified "2023-10-17" @default.
• W4377011856 title "Ability of <scp>SpikoGen</scp>®, an <scp>Advax‐CpG</scp> adjuvanted recombinant spike protein vaccine, to induce cross‐neutralising antibodies against <scp>SARS‐CoV</scp>‐2 variants" @default.
• W4377011856 cites W1658267367 @default.
• W4377011856 cites W2004433396 @default.
• W4377011856 cites W2058327521 @default.
• W4377011856 cites W2148888494 @default.
• W4377011856 cites W2460836560 @default.
• W4377011856 cites W3020828664 @default.
• W4377011856 cites W3096064145 @default.
• W4377011856 cites W3111255098 @default.
• W4377011856 cites W3111590711 @default.
• W4377011856 cites W3127329393 @default.
• W4377011856 cites W3133327867 @default.
• W4377011856 cites W3157709232 @default.
• W4377011856 cites W3187116858 @default.
• W4377011856 cites W3217661335 @default.
• W4377011856 cites W4200033584 @default.
• W4377011856 cites W4205483821 @default.
• W4377011856 cites W4206997499 @default.
• W4377011856 cites W4220739072 @default.
• W4377011856 cites W4224015733 @default.
• W4377011856 cites W4224058578 @default.
• W4377011856 cites W4281291961 @default.
• W4377011856 cites W4282923705 @default.
• W4377011856 cites W4283592844 @default.
• W4377011856 cites W4293512905 @default.
• W4377011856 cites W4293577332 @default.
• W4377011856 cites W4293843074 @default.
• W4377011856 cites W4295125732 @default.
• W4377011856 cites W4311448444 @default.
• W4377011856 doi "https://doi.org/10.1111/imm.13661" @default.
• W4377011856 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37199229" @default.
• W4377011856 hasPublicationYear "2023" @default.
• W4377011856 type Work @default.
• W4377011856 citedByCount "3" @default.
• W4377011856 countsByYear W43770118562023 @default.
• W4377011856 crossrefType "journal-article" @default.
• W4377011856 hasAuthorship W4377011856A5012651782 @default.
• W4377011856 hasAuthorship W4377011856A5014163577 @default.
• W4377011856 hasAuthorship W4377011856A5048011861 @default.
• W4377011856 hasAuthorship W4377011856A5061251507 @default.
• W4377011856 hasAuthorship W4377011856A5070788647 @default.
• W4377011856 hasAuthorship W4377011856A5079311523 @default.
• W4377011856 hasConcept C104317684 @default.
• W4377011856 hasConcept C12590561 @default.
• W4377011856 hasConcept C14086860 @default.
• W4377011856 hasConcept C142724271 @default.
• W4377011856 hasConcept C159047783 @default.
• W4377011856 hasConcept C159654299 @default.
• W4377011856 hasConcept C203014093 @default.
• W4377011856 hasConcept C204787440 @default.
• W4377011856 hasConcept C27081682 @default.
• W4377011856 hasConcept C2777863537 @default.
• W4377011856 hasConcept C32611913 @default.
• W4377011856 hasConcept C40767141 @default.
• W4377011856 hasConcept C55493867 @default.
• W4377011856 hasConcept C71924100 @default.
• W4377011856 hasConcept C86803240 @default.
• W4377011856 hasConceptScore W4377011856C104317684 @default.
• W4377011856 hasConceptScore W4377011856C12590561 @default.
• W4377011856 hasConceptScore W4377011856C14086860 @default.
• W4377011856 hasConceptScore W4377011856C142724271 @default.
• W4377011856 hasConceptScore W4377011856C159047783 @default.
• W4377011856 hasConceptScore W4377011856C159654299 @default.
• W4377011856 hasConceptScore W4377011856C203014093 @default.
• W4377011856 hasConceptScore W4377011856C204787440 @default.
• W4377011856 hasConceptScore W4377011856C27081682 @default.
• W4377011856 hasConceptScore W4377011856C2777863537 @default.
• W4377011856 hasConceptScore W4377011856C32611913 @default.
• W4377011856 hasConceptScore W4377011856C40767141 @default.
• W4377011856 hasConceptScore W4377011856C55493867 @default.
• W4377011856 hasConceptScore W4377011856C71924100 @default.
• W4377011856 hasConceptScore W4377011856C86803240 @default.
• W4377011856 hasFunder F4320328430 @default.
• W4377011856 hasFunder F4320337355 @default.
• W4377011856 hasIssue "2" @default.
• W4377011856 hasLocation W43770118561 @default.
• W4377011856 hasLocation W43770118562 @default.
• W4377011856 hasOpenAccess W4377011856 @default.
• W4377011856 hasPrimaryLocation W43770118561 @default.
• W4377011856 hasRelatedWork W1859326399 @default.
• W4377011856 hasRelatedWork W1970473549 @default.
• W4377011856 hasRelatedWork W2000111628 @default.
• W4377011856 hasRelatedWork W2077622600 @default.
• W4377011856 hasRelatedWork W2095243290 @default.
• W4377011856 hasRelatedWork W2151437734 @default.
• W4377011856 hasRelatedWork W2274607931 @default.
• W4377011856 hasRelatedWork W2323301649 @default.
• W4377011856 hasRelatedWork W2375279375 @default.

• next