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- W4377012052 abstract "Abstract One of the most orthopedic problems seen in the equine is osteoarthritis (OA). The present study tracks some biochemical, epigenetic, and transcriptomic factors along different stages of monoiodoacetate (MIA) induced OA in donkeys in serum and synovial fluid. The aim of the study was the detection of sensitive noninvasive early biomarkers. OA was induced by a single intra-articular injection of 25 mg of MIA into the left radiocarpal joint of nine donkeys. Serum and synovial samples were taken at zero-day and different intervals for assessment of total GAGs and CS levels as well as miR-146b, miR-27b, TRAF-6, and COL10A1 gene expression. The results showed that the total GAGs and CS levels increased in different stages of OA. The level of expression of both miR-146b and miR-27b were upregulated as OA progressed and then downregulated at late stages. TRAF-6 gene was upregulated at the late stage while synovial fluid COL10A1 was over-expressed at the early stage of OA and then decreased at the late stages (P < 0.05). In conclusion, both miR-146b and miR-27b together with COL10A1 could be used as promising noninvasive biomarkers for the very early diagnosis of OA." @default.
- W4377012052 created "2023-05-19" @default.
- W4377012052 creator A5005008428 @default.
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- W4377012052 creator A5040419538 @default.
- W4377012052 creator A5046526118 @default.
- W4377012052 creator A5076194373 @default.
- W4377012052 date "2023-05-17" @default.
- W4377012052 modified "2023-09-30" @default.
- W4377012052 title "Circulating miR-146b and miR-27b are efficient biomarkers for early diagnosis of Equidae osteoarthritis" @default.
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- W4377012052 doi "https://doi.org/10.1038/s41598-023-35207-3" @default.
- W4377012052 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37198318" @default.