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• W4377012335 abstract "Left atrial (LA) epicardial adipose tissue (EAT) reportedly creates inflammatory milieu and underlies the pathophysiology of atrial fibrillation (AF). LA EAT volume has reportedly affected the outcome of catheter ablation for AF and can be clinically measured by cardiac computer tomography (CT). We hypothesized that the radiodensity of atrial EAT evaluated by cardiac CT reflects the adipose cell/tissue characteristics of remodeled atria in AF patients. The aim of this study is to examine the relationship between the EAT radiodensity of cardiac CT and the adipose cell/tissue characteristics in AF patients and to assess its link to the clinical outcome in those undergoing catheter ablation (CA). Cardiac CT was performed in AF patients undergoing cardiovascular surgery (n=10). LA appendage tissues with EAT were obtained during the operation. Hematoxylin eosin/Masson’s trichrome staining was performed: fibrosis and adipose cell size in EAT were evaluated with ImageJ software. Adipose cell heterogeneity index (AHI) was defined as the percentage of standard deviation to average cell size. These were related to carduac CT-based radiodensity (EATR, Zaiostation, ziosoft) in the corresponding EAT area in the same patients. In another subset of AF patients undergoing CA (n=120), cardiac CT was performed 1 week before and 3-6 month after the procedure; the CT-based EATR and the volume of LA EAT (EATV) were measured (EnSiteTM VerismoTM software, Abbott). The time-course change of the EATV and EATR was related to AF recurrence after CA. EATR was correlated with CT-based LA volume index (an index of atrial remodeling) and EATV. Adipocyte deformation and fibrosis were remarkable in the area with high CT-based EATR vs. low EATR (Figure). EATR was negatively correlated with adipose cell size (r=-0.734, p<0.05) but positively correlated with fibrosis (r=0.735, p<0.05) and AHI (r=0.725, p<0.05), suggesting greater fibrofatty change in the high EATR. In 120 AF patients undergoing CA, those with the larger reduction of EATV during the follow-up (3-6 month after the procedure) showed the greater attenuation of EATR. In multivariate analysis, the EATR attenuation is an independent predictor for AF recurrence after CA. CT-based EATR can estimate local fibrofatty change with heterogeneous adipose cell deformation and is associated with progression of atrial structural remodeling. Time-course change of EATR is an independent predictor for AF recurrence after CA." @default.
• W4377012335 created "2023-05-19" @default.
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• W4377012335 date "2023-05-01" @default.
• W4377012335 modified "2023-09-27" @default.
• W4377012335 title "PO-01-201 HIGHER RADIODENSITY OF CARDIAC COMPUTED TOMOGRAPHY IS ASSOCIATED WITH GREATER FIBROFATTY CHANGE/CELLULAR DEFORMATION IN EPICARDIAL ADIPOSE TISSUE OF PATIENTS WITH ATRIAL FIBRILLATION" @default.
• W4377012335 doi "https://doi.org/10.1016/j.hrthm.2023.03.577" @default.
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