FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377012818> ?p ?o ?g. }

• W4377012818 abstract "The KEYNOTE-811 study exhibited promising preliminary results for HER2-positive metastasis gastric adenocarcinoma; however, long-term survival benefit remains to be determined.In this single-center, controlled, retrospective study, patients with histologically confirmed HER2-positive unresectable or metastatic gastric/gastroesophageal adenocarcinoma received either anti-PD-1 antibody combined with trastuzumab and chemotherapy (cohort A) or trastuzumab and chemotherapy treatment (cohort B). The primary end points were progression-free survival (PFS) and overall survival (OS). The secondary end points were objective response rate (ORR), disease control rate (DCR), and duration of response (DoR).A total of 56 patients were eligible to join the study, with 30 patients in cohort A and 26 patients in cohort B. The median PFS (mPFS) was 16.2 months (95% CI, 15.093-17.307) in cohort A versus 14.5 months (95% CI, 9.491-19.509) in cohort B (p = 0.58). The median OS in cohort A was 28.1 months (95% CI, 17.625-38.575) versus 31.6 months (95% CI, 13.757-49.443) in cohort B (p = 0.534). ORRs were 66.7% and 50% in the two groups, respectively. DCRs were 90% and 84.6% in the two groups. Median DoR was not reached in cohort A and it was 16.3 (95% CI, 8.453-24.207) months in cohort B (p = 0.141). The most common irAEs were grade 1 hypothyroidism (33.3%) in cohort A. No treatment-related deaths occurred in this study.This retrospective cohort study provided a preliminary picture on the long-term follow-up of combining anti-PD-1 antibody with trastuzumab and chemotherapy in HER2-positive GC, and a trend with longer DoR and ORR was identified. Further studies with larger sample sizes and more in-depth molecular investigation are needed." @default.
• W4377012818 created "2023-05-19" @default.
• W4377012818 creator A5000176820 @default.
• W4377012818 creator A5011509212 @default.
• W4377012818 creator A5040697321 @default.
• W4377012818 creator A5041588764 @default.
• W4377012818 creator A5043225123 @default.
• W4377012818 creator A5075345467 @default.
• W4377012818 creator A5081675173 @default.
• W4377012818 creator A5085296684 @default.
• W4377012818 date "2023-05-18" @default.
• W4377012818 modified "2023-09-29" @default.
• W4377012818 title "Efficacy and survival of anti-PD-1 antibody in combination with trastuzumab and chemotherapy versus trastuzumab and chemotherapy as first-line treatment of HER2-positive metastasis gastric adenocarcinoma: a retrospective study" @default.
• W4377012818 cites W1964321121 @default.
• W4377012818 cites W2006710185 @default.
• W4377012818 cites W2066471812 @default.
• W4377012818 cites W2100439220 @default.
• W4377012818 cites W2272984102 @default.
• W4377012818 cites W2515968420 @default.
• W4377012818 cites W2598633947 @default.
• W4377012818 cites W2745792339 @default.
• W4377012818 cites W2794577178 @default.
• W4377012818 cites W2801657532 @default.
• W4377012818 cites W2891942735 @default.
• W4377012818 cites W2892163061 @default.
• W4377012818 cites W2900717255 @default.
• W4377012818 cites W2945045362 @default.
• W4377012818 cites W3042132061 @default.
• W4377012818 cites W3109189796 @default.
• W4377012818 cites W3111845861 @default.
• W4377012818 cites W3128646645 @default.
• W4377012818 cites W3159546116 @default.
• W4377012818 cites W3167070359 @default.
• W4377012818 cites W3171517418 @default.
• W4377012818 cites W3203083241 @default.
• W4377012818 cites W3204588330 @default.
• W4377012818 cites W4200595129 @default.
• W4377012818 cites W4206384216 @default.
• W4377012818 cites W4238854583 @default.
• W4377012818 cites W4283315303 @default.
• W4377012818 cites W4283713242 @default.
• W4377012818 cites W4284695981 @default.
• W4377012818 cites W4284895135 @default.
• W4377012818 cites W4290465861 @default.
• W4377012818 cites W4304690509 @default.
• W4377012818 doi "https://doi.org/10.3389/fonc.2023.1166040" @default.
• W4377012818 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37274273" @default.
• W4377012818 hasPublicationYear "2023" @default.
• W4377012818 type Work @default.
• W4377012818 citedByCount "1" @default.
• W4377012818 countsByYear W43770128182023 @default.
• W4377012818 crossrefType "journal-article" @default.
• W4377012818 hasAuthorship W4377012818A5000176820 @default.
• W4377012818 hasAuthorship W4377012818A5011509212 @default.
• W4377012818 hasAuthorship W4377012818A5040697321 @default.
• W4377012818 hasAuthorship W4377012818A5041588764 @default.
• W4377012818 hasAuthorship W4377012818A5043225123 @default.
• W4377012818 hasAuthorship W4377012818A5075345467 @default.
• W4377012818 hasAuthorship W4377012818A5081675173 @default.
• W4377012818 hasAuthorship W4377012818A5085296684 @default.
• W4377012818 hasBestOaLocation W43770128181 @default.
• W4377012818 hasConcept C121608353 @default.
• W4377012818 hasConcept C126322002 @default.
• W4377012818 hasConcept C141071460 @default.
• W4377012818 hasConcept C143998085 @default.
• W4377012818 hasConcept C167135981 @default.
• W4377012818 hasConcept C2776694085 @default.
• W4377012818 hasConcept C2779786085 @default.
• W4377012818 hasConcept C530470458 @default.
• W4377012818 hasConcept C71924100 @default.
• W4377012818 hasConcept C72563966 @default.
• W4377012818 hasConcept C90924648 @default.
• W4377012818 hasConceptScore W4377012818C121608353 @default.
• W4377012818 hasConceptScore W4377012818C126322002 @default.
• W4377012818 hasConceptScore W4377012818C141071460 @default.
• W4377012818 hasConceptScore W4377012818C143998085 @default.
• W4377012818 hasConceptScore W4377012818C167135981 @default.
• W4377012818 hasConceptScore W4377012818C2776694085 @default.
• W4377012818 hasConceptScore W4377012818C2779786085 @default.
• W4377012818 hasConceptScore W4377012818C530470458 @default.
• W4377012818 hasConceptScore W4377012818C71924100 @default.
• W4377012818 hasConceptScore W4377012818C72563966 @default.
• W4377012818 hasConceptScore W4377012818C90924648 @default.
• W4377012818 hasLocation W43770128181 @default.
• W4377012818 hasLocation W43770128182 @default.
• W4377012818 hasLocation W43770128183 @default.
• W4377012818 hasOpenAccess W4377012818 @default.
• W4377012818 hasPrimaryLocation W43770128181 @default.
• W4377012818 hasRelatedWork W1976609613 @default.
• W4377012818 hasRelatedWork W2030434439 @default.
• W4377012818 hasRelatedWork W2050439103 @default.
• W4377012818 hasRelatedWork W2218005127 @default.
• W4377012818 hasRelatedWork W2316766300 @default.
• W4377012818 hasRelatedWork W2394251095 @default.
• W4377012818 hasRelatedWork W2984545096 @default.
• W4377012818 hasRelatedWork W3030622551 @default.
• W4377012818 hasRelatedWork W3133071720 @default.
• W4377012818 hasRelatedWork W3204642901 @default.
• W4377012818 hasVolume "13" @default.
• W4377012818 isParatext "false" @default.

• next