FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377012829> ?p ?o ?g. }

• W4377012829 abstract "Abstract Background Idiopathic pulmonary fibrosis (IPF) is a fibrotic lung disorder of unknown cause, affecting about three million people worldwide. Being a multifactorial disease, complex genetic and environmental factors contribute to its susceptibility. Therefore, we conducted a two-staged systematic literature search and meta-analyses of published genetic association studies on IPF. Methods The first search was performed using PubMed and Web of Science, retrieving a total of 5642 articles, of which 57 publications were eligible for inclusion in the first stage. The Second search was performed using PubMed, Web of Science and Scopus for all genetic variants, identified from the first search, with 2 or more studies. Thus, six variants [rs35705950 ( MUC5B ), rs2736100 ( TERT ), rs2609255 ( FAM13A ), rs2076295 ( DSP ), rs12610495 ( DPP9 ) and rs1800470 ( TGF-β1 )] from this search qualified for meta-analyses. Additionally, the epidemiological credibility of these six variants was evaluated using the Venice criteria. Results In this systematic review, 291 polymorphisms were found to be associated with IPF susceptibility. Meta-analyses findings revealed significant (p < 0.05) risk association of rs35705950 [T vs C; OR = 3.85(3.24-4.47)], rs2609255 [G vs T; OR = 1.37(1.27-1.47)], rs2076295 [G vs T; OR = 1.31(1.00-1.63)], rs12610495 [G vs A; OR = 1.29(1.21-1.37)] and rs1800470 [T vs C; OR = 1.08(0.82-1.34)] and protective association of rs2736100 [C vs A; OR = 0.70(0.61-0.79)] with IPF susceptibility. Cumulative epidemiological evidence was graded as strong for rs35705950, moderate for rs2736100, rs2609255 and rs12610495, and weak for rs2076295 and rs1800470. Conclusions Our findings present the most prominent IPF-associated genetic risk variants involved in alveolar epithelial injuries ( MUC5B, TERT, FAM13A, DSP, DPP9 ) and epithelial-mesenchymal transition ( TGF-β1 ), providing genetic and biological insights into IPF pathogenesis." @default.
• W4377012829 created "2023-05-19" @default.
• W4377012829 creator A5054248469 @default.
• W4377012829 creator A5070900960 @default.
• W4377012829 creator A5081940133 @default.
• W4377012829 creator A5091274298 @default.
• W4377012829 date "2023-05-18" @default.
• W4377012829 modified "2023-09-28" @default.
• W4377012829 title "Genetic landscape of idiopathic pulmonary fibrosis: A systematic review, meta-analysis and epidemiological evidence of case-control studies" @default.
• W4377012829 cites W1483216211 @default.
• W4377012829 cites W1518683432 @default.
• W4377012829 cites W1617328014 @default.
• W4377012829 cites W1759114984 @default.
• W4377012829 cites W1922570445 @default.
• W4377012829 cites W1938547050 @default.
• W4377012829 cites W1951049964 @default.
• W4377012829 cites W1968058618 @default.
• W4377012829 cites W1971738121 @default.
• W4377012829 cites W1978257813 @default.
• W4377012829 cites W1978678714 @default.
• W4377012829 cites W1978870183 @default.
• W4377012829 cites W1985106829 @default.
• W4377012829 cites W1993712652 @default.
• W4377012829 cites W1995105009 @default.
• W4377012829 cites W1999438865 @default.
• W4377012829 cites W2003514025 @default.
• W4377012829 cites W2004697839 @default.
• W4377012829 cites W2024809912 @default.
• W4377012829 cites W2037645843 @default.
• W4377012829 cites W2053007357 @default.
• W4377012829 cites W2053456156 @default.
• W4377012829 cites W2053863431 @default.
• W4377012829 cites W2055245602 @default.
• W4377012829 cites W2072596370 @default.
• W4377012829 cites W2085498591 @default.
• W4377012829 cites W2086838781 @default.
• W4377012829 cites W2087442158 @default.
• W4377012829 cites W2103168499 @default.
• W4377012829 cites W2103258766 @default.
• W4377012829 cites W2116475791 @default.
• W4377012829 cites W2125435699 @default.
• W4377012829 cites W2126930838 @default.
• W4377012829 cites W2131839486 @default.
• W4377012829 cites W2138598430 @default.
• W4377012829 cites W2148856655 @default.
• W4377012829 cites W2149661971 @default.
• W4377012829 cites W2150448842 @default.
• W4377012829 cites W2152641884 @default.
• W4377012829 cites W2157823046 @default.
• W4377012829 cites W2167383172 @default.
• W4377012829 cites W2182951450 @default.
• W4377012829 cites W2199015651 @default.
• W4377012829 cites W2226046576 @default.
• W4377012829 cites W2231464875 @default.
• W4377012829 cites W2257101296 @default.
• W4377012829 cites W2258717577 @default.
• W4377012829 cites W2271349749 @default.
• W4377012829 cites W2331712921 @default.
• W4377012829 cites W2416914730 @default.
• W4377012829 cites W2518937126 @default.
• W4377012829 cites W2561296359 @default.
• W4377012829 cites W2581927130 @default.
• W4377012829 cites W2626588662 @default.
• W4377012829 cites W2767079004 @default.
• W4377012829 cites W2770021504 @default.
• W4377012829 cites W2788593837 @default.
• W4377012829 cites W2807259602 @default.
• W4377012829 cites W2809175950 @default.
• W4377012829 cites W2889197569 @default.
• W4377012829 cites W2943293482 @default.
• W4377012829 cites W2947366664 @default.
• W4377012829 cites W2983449145 @default.
• W4377012829 cites W3005775962 @default.
• W4377012829 cites W3013675405 @default.
• W4377012829 cites W3036253003 @default.
• W4377012829 cites W3135081070 @default.
• W4377012829 cites W3193534817 @default.
• W4377012829 cites W4251793763 @default.
• W4377012829 doi "https://doi.org/10.1101/2023.05.18.23290164" @default.
• W4377012829 hasPublicationYear "2023" @default.
• W4377012829 type Work @default.
• W4377012829 citedByCount "0" @default.
• W4377012829 crossrefType "posted-content" @default.
• W4377012829 hasAuthorship W4377012829A5054248469 @default.
• W4377012829 hasAuthorship W4377012829A5070900960 @default.
• W4377012829 hasAuthorship W4377012829A5081940133 @default.
• W4377012829 hasAuthorship W4377012829A5091274298 @default.
• W4377012829 hasBestOaLocation W43770128291 @default.
• W4377012829 hasConcept C107130276 @default.
• W4377012829 hasConcept C126322002 @default.
• W4377012829 hasConcept C2776478404 @default.
• W4377012829 hasConcept C2777714996 @default.
• W4377012829 hasConcept C2778341716 @default.
• W4377012829 hasConcept C3020774429 @default.
• W4377012829 hasConcept C71924100 @default.
• W4377012829 hasConcept C95190672 @default.
• W4377012829 hasConceptScore W4377012829C107130276 @default.
• W4377012829 hasConceptScore W4377012829C126322002 @default.
• W4377012829 hasConceptScore W4377012829C2776478404 @default.
• W4377012829 hasConceptScore W4377012829C2777714996 @default.

• next