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• W4377012882 abstract "Abstract Immune mechanisms that modulate human immunodeficiency virus-1 (HIV-1) reservoir size in neonates are poorly understood. Using samples from neonates who initiated antiretroviral therapy shortly after birth, we demonstrate that interleukin-8–secreting CD4 T cells, which are selectively expanded in early infancy, are more resistant to HIV-1 infection and inversely correlated with the frequency of intact proviruses at birth. Moreover, newborns with HIV-1 infection displayed a distinct B-cell profile at birth, with reduction of memory B cells and expansion of plasmablasts and transitional B cells; however, B-cell immune perturbations were unrelated to HIV-1 reservoir size and normalized after initiation of antiretroviral therapy. Clinical Trials Registration. NCT02369406." @default.
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• W4377012882 date "2023-05-18" @default.
• W4377012882 modified "2023-10-17" @default.
• W4377012882 title "Immune Modulation of HIV-1 Reservoir Size in Early-Treated Neonates" @default.
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• W4377012882 doi "https://doi.org/10.1093/infdis/jiad173" @default.
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