FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377012893> ?p ?o ?g. }

• W4377012893 endingPage "S658" @default.
• W4377012893 startingPage "S657" @default.
• W4377012893 abstract "Sudden cardiac death (SCD), caused by ventricular arrhythmias (VA), is a major cause of death. Rates of SCD and VA are known to be affected by race and gender. Minorities have worse outcomes and are less likely to receive primary prevention ICDs. Representation of minorities in VA trials is not well documented. To evaluate sex, racial and ethnic inclusion rates in VA trials. The NIH website ClinicalTrials.gov was queried for trials including the terms “ventricular tachycardia,” ventricular fibrillation, or sudden cardiac death. Only trials that were completed with results available were included. All trials were manually reviewed and results confirmed in manuscript, if available. Patient sex, race, and ethnicity data were recorded. Race and ethnicity categories were defined according to 2015 NIH statement. Trials were divided based on funding source (academic, industry or federal), start date, focus of trial (prevention/detection or treatment), and etiology of VA (ischemic, structural, genetic/idiopathic, not specified/all). To examine representation based on incidence of VT/VF in the population, participation to incidence ratio (PIR) was calculated by dividing the percentage of a group among trial participants by the percentage of that group among the disease population. Values of 0.8 to 1.2 reflect similar representation. Participation to total population ratio (PTPR) was also calculated by dividing the percentage of a group among trial participants by total US population of that group based on current census data. Thirty-seven trials were identified. Three were excluded for not pertaining to VA, for a total of 34 trials with start dates ranging from 7/2005 to 8/2020. All trials represented sex. Of the 12,532 participants, 23.5% were female. Twenty-one (61.8%) trials with 7,205 participants reported race: White (77.5%), Black or African American (14.6%), Asian (2.3%), AIAN (0.8%), NHPI (0.2%), >1 race (0.5), other/unknown (3.3%). Twelve (35.3%) trials, which included 3,077 participants, reported ethnicity: Hispanic (3.1%), non-Hispanic (96.6%), other/not reported (0.3%). PIR and PTPR, stratified by funding source, start date, focus of trial and etiology of VA are shown in figure. Only two-thirds of the trials reported race, and minorities remain underrepresented. White males continue to be overrepresented in clinical trials including those funded by federal government. Findings from these trials may not be generalizable." @default.
• W4377012893 created "2023-05-19" @default.
• W4377012893 creator A5002860390 @default.
• W4377012893 creator A5054608763 @default.
• W4377012893 creator A5062258854 @default.
• W4377012893 creator A5068492051 @default.
• W4377012893 date "2023-05-01" @default.
• W4377012893 modified "2023-09-24" @default.
• W4377012893 title "PO-05-160 SYSTEMATIC REVIEW AND META-ANALYSIS: INCLUSION OF GENDER, RACIAL AND ETHNIC MINORITIES IN VENTRICULAR ARRHYTHMIA AND SUDDEN CARDIAC DEATH TRIALS" @default.
• W4377012893 doi "https://doi.org/10.1016/j.hrthm.2023.03.1374" @default.
• W4377012893 hasPublicationYear "2023" @default.
• W4377012893 type Work @default.
• W4377012893 citedByCount "0" @default.
• W4377012893 crossrefType "journal-article" @default.
• W4377012893 hasAuthorship W4377012893A5002860390 @default.
• W4377012893 hasAuthorship W4377012893A5054608763 @default.
• W4377012893 hasAuthorship W4377012893A5062258854 @default.
• W4377012893 hasAuthorship W4377012893A5068492051 @default.
• W4377012893 hasBestOaLocation W43770128931 @default.
• W4377012893 hasConcept C120665830 @default.
• W4377012893 hasConcept C121332964 @default.
• W4377012893 hasConcept C126322002 @default.
• W4377012893 hasConcept C137403100 @default.
• W4377012893 hasConcept C144024400 @default.
• W4377012893 hasConcept C149923435 @default.
• W4377012893 hasConcept C164705383 @default.
• W4377012893 hasConcept C19165224 @default.
• W4377012893 hasConcept C2775935837 @default.
• W4377012893 hasConcept C2776331378 @default.
• W4377012893 hasConcept C2781005686 @default.
• W4377012893 hasConcept C2908647359 @default.
• W4377012893 hasConcept C2993353509 @default.
• W4377012893 hasConcept C535046627 @default.
• W4377012893 hasConcept C61511704 @default.
• W4377012893 hasConcept C71924100 @default.
• W4377012893 hasConcept C99454951 @default.
• W4377012893 hasConceptScore W4377012893C120665830 @default.
• W4377012893 hasConceptScore W4377012893C121332964 @default.
• W4377012893 hasConceptScore W4377012893C126322002 @default.
• W4377012893 hasConceptScore W4377012893C137403100 @default.
• W4377012893 hasConceptScore W4377012893C144024400 @default.
• W4377012893 hasConceptScore W4377012893C149923435 @default.
• W4377012893 hasConceptScore W4377012893C164705383 @default.
• W4377012893 hasConceptScore W4377012893C19165224 @default.
• W4377012893 hasConceptScore W4377012893C2775935837 @default.
• W4377012893 hasConceptScore W4377012893C2776331378 @default.
• W4377012893 hasConceptScore W4377012893C2781005686 @default.
• W4377012893 hasConceptScore W4377012893C2908647359 @default.
• W4377012893 hasConceptScore W4377012893C2993353509 @default.
• W4377012893 hasConceptScore W4377012893C535046627 @default.
• W4377012893 hasConceptScore W4377012893C61511704 @default.
• W4377012893 hasConceptScore W4377012893C71924100 @default.
• W4377012893 hasConceptScore W4377012893C99454951 @default.
• W4377012893 hasIssue "5" @default.
• W4377012893 hasLocation W43770128931 @default.
• W4377012893 hasOpenAccess W4377012893 @default.
• W4377012893 hasPrimaryLocation W43770128931 @default.
• W4377012893 hasRelatedWork W1534090624 @default.
• W4377012893 hasRelatedWork W2009378781 @default.
• W4377012893 hasRelatedWork W2063054225 @default.
• W4377012893 hasRelatedWork W2127465013 @default.
• W4377012893 hasRelatedWork W2131262499 @default.
• W4377012893 hasRelatedWork W2146285818 @default.
• W4377012893 hasRelatedWork W2411658205 @default.
• W4377012893 hasRelatedWork W2945088353 @default.
• W4377012893 hasRelatedWork W3146409838 @default.
• W4377012893 hasRelatedWork W4290199961 @default.
• W4377012893 hasVolume "20" @default.
• W4377012893 isParatext "false" @default.
• W4377012893 isRetracted "false" @default.
• W4377012893 workType "article" @default.