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- W4377013212 endingPage "533" @default.
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- W4377013212 abstract "The contribution of new mutations to phenotypic variation and the consequences of this variation for individual fitness are fundamental concepts for understanding genetic variation and adaptation. Here, we investigated how mutation influenced variation in a complex trait in zebrafish, Danio rerio. Typical of many ecologically relevant traits in ectotherms, swimming speed in fish is temperature dependent, with evidence of adaptive evolution of thermal performance. We chemically induced novel germline point mutations in males and measured sprint speed in their sons at six temperatures (between 16°C and 34°C). Heterozygous mutational effects on speed were strongly positively correlated among temperatures, resulting in statistical support for only a single axis of mutational variation, reflecting temperature-independent variation in speed (faster-slower mode). These results suggest pleiotropic effects on speed across different temperatures; however, spurious correlations arise via linkage or heterogeneity in mutation number when mutations have consistent directional effects on each trait. Here, mutation did not change mean speed, indicating no directional bias in mutational effects. The results contribute to emerging evidence that mutations may predominantly have synergistic cross-environment effects, in contrast to conditionally neutral or antagonistic effects that underpin thermal adaptation. We discuss several aspects of experimental design that may affect resolution of mutations with nonsynergistic effects." @default.
- W4377013212 created "2023-05-19" @default.
- W4377013212 creator A5033773384 @default.
- W4377013212 creator A5035695817 @default.
- W4377013212 creator A5045104302 @default.
- W4377013212 creator A5056631946 @default.
- W4377013212 date "2023-10-01" @default.
- W4377013212 modified "2023-10-12" @default.
- W4377013212 title "The Contribution of Mutation to Variation in Temperature-Dependent Sprint Speed in Zebrafish, <i>Danio rerio</i>" @default.
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