Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377013250> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W4377013250 endingPage "1519" @default.
- W4377013250 startingPage "1512" @default.
- W4377013250 abstract "One new aromatic polyketide, prealnumycin B (1), and four known aromatic polyketides, K1115A (2), 1,6-dihydroxy-8-propylanthraquinone (DHPA, 3), phaeochromycin B (4), and (R)-7-acetyl-3,6-dihydroxy-8-propyl-3,4dihydronaphthalen-1(2H)-one (5), were isolated from the marine-derived Streptomyces sundarbansensis SCSIO NS01; these compounds represent four sets of aromatic polyketides differing in size and shape. A type II polyketide synthase (PKS) cluster, als, was identified by complete genome sequencing and was shown, by in vivo gene inactivation experiments in the wild-type (WT) NS01 strain and heterologous expression experiments, to encode the biosynthesis of compounds 1–5. Moreover, heterologous expression of the als cluster afforded three additional aromatic polyketides representing two different carbon skeletons, the new phaeochromycin L (6) and two known aromatic polyketides, phaeochromycins D (7) and E (8). These findings expand our knowledge of type II PKS machineries and their versatility in generating structurally diverse aromatic polyketides and highlight the power of type II PKSs in accessing new polyketides via ectopic expression in heterologous hosts." @default.
- W4377013250 created "2023-05-19" @default.
- W4377013250 creator A5005136536 @default.
- W4377013250 creator A5008798308 @default.
- W4377013250 creator A5028227890 @default.
- W4377013250 creator A5042804558 @default.
- W4377013250 creator A5077847368 @default.
- W4377013250 creator A5078561503 @default.
- W4377013250 date "2023-05-18" @default.
- W4377013250 modified "2023-10-17" @default.
- W4377013250 title "Six Sets of Aromatic Polyketides Differing in Size and Shape Derive from a Single Biosynthetic Gene Cluster" @default.
- W4377013250 cites W1977659555 @default.
- W4377013250 cites W2024192544 @default.
- W4377013250 cites W2029663663 @default.
- W4377013250 cites W2035378670 @default.
- W4377013250 cites W2072201936 @default.
- W4377013250 cites W2080824596 @default.
- W4377013250 cites W2110609038 @default.
- W4377013250 cites W2112960513 @default.
- W4377013250 cites W2116137883 @default.
- W4377013250 cites W2159489517 @default.
- W4377013250 cites W2233852516 @default.
- W4377013250 cites W2311203695 @default.
- W4377013250 cites W2734431286 @default.
- W4377013250 cites W2781703209 @default.
- W4377013250 cites W2899217278 @default.
- W4377013250 cites W3161596995 @default.
- W4377013250 cites W4200166243 @default.
- W4377013250 cites W4322720314 @default.
- W4377013250 doi "https://doi.org/10.1021/acs.jnatprod.3c00202" @default.
- W4377013250 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37200613" @default.
- W4377013250 hasPublicationYear "2023" @default.
- W4377013250 type Work @default.
- W4377013250 citedByCount "0" @default.
- W4377013250 crossrefType "journal-article" @default.
- W4377013250 hasAuthorship W4377013250A5005136536 @default.
- W4377013250 hasAuthorship W4377013250A5008798308 @default.
- W4377013250 hasAuthorship W4377013250A5028227890 @default.
- W4377013250 hasAuthorship W4377013250A5042804558 @default.
- W4377013250 hasAuthorship W4377013250A5077847368 @default.
- W4377013250 hasAuthorship W4377013250A5078561503 @default.
- W4377013250 hasConcept C104317684 @default.
- W4377013250 hasConcept C108305142 @default.
- W4377013250 hasConcept C185592680 @default.
- W4377013250 hasConcept C2778635478 @default.
- W4377013250 hasConcept C2779920670 @default.
- W4377013250 hasConcept C2780115692 @default.
- W4377013250 hasConcept C36857842 @default.
- W4377013250 hasConcept C40767141 @default.
- W4377013250 hasConcept C523546767 @default.
- W4377013250 hasConcept C54355233 @default.
- W4377013250 hasConcept C553450214 @default.
- W4377013250 hasConcept C55493867 @default.
- W4377013250 hasConcept C71240020 @default.
- W4377013250 hasConcept C86803240 @default.
- W4377013250 hasConceptScore W4377013250C104317684 @default.
- W4377013250 hasConceptScore W4377013250C108305142 @default.
- W4377013250 hasConceptScore W4377013250C185592680 @default.
- W4377013250 hasConceptScore W4377013250C2778635478 @default.
- W4377013250 hasConceptScore W4377013250C2779920670 @default.
- W4377013250 hasConceptScore W4377013250C2780115692 @default.
- W4377013250 hasConceptScore W4377013250C36857842 @default.
- W4377013250 hasConceptScore W4377013250C40767141 @default.
- W4377013250 hasConceptScore W4377013250C523546767 @default.
- W4377013250 hasConceptScore W4377013250C54355233 @default.
- W4377013250 hasConceptScore W4377013250C553450214 @default.
- W4377013250 hasConceptScore W4377013250C55493867 @default.
- W4377013250 hasConceptScore W4377013250C71240020 @default.
- W4377013250 hasConceptScore W4377013250C86803240 @default.
- W4377013250 hasFunder F4320321001 @default.
- W4377013250 hasFunder F4320321921 @default.
- W4377013250 hasIssue "6" @default.
- W4377013250 hasLocation W43770132501 @default.
- W4377013250 hasLocation W43770132502 @default.
- W4377013250 hasOpenAccess W4377013250 @default.
- W4377013250 hasPrimaryLocation W43770132501 @default.
- W4377013250 hasRelatedWork W1971598639 @default.
- W4377013250 hasRelatedWork W2004879432 @default.
- W4377013250 hasRelatedWork W2076277544 @default.
- W4377013250 hasRelatedWork W2127954263 @default.
- W4377013250 hasRelatedWork W2160105999 @default.
- W4377013250 hasRelatedWork W2779189714 @default.
- W4377013250 hasRelatedWork W2792397032 @default.
- W4377013250 hasRelatedWork W2888485276 @default.
- W4377013250 hasRelatedWork W3000218453 @default.
- W4377013250 hasRelatedWork W3190166639 @default.
- W4377013250 hasVolume "86" @default.
- W4377013250 isParatext "false" @default.
- W4377013250 isRetracted "false" @default.
- W4377013250 workType "article" @default.