Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377013334> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W4377013334 abstract "Abstract Background Microglial activation plays a crucial role in the disease progression in amyotrophic lateral sclerosis (ALS). Interleukin receptor-associated kinases-M (IRAK-M) is an important negative regulatory factor in the Toll-like receptor 4 (TLR4) pathway during microglia activation, and its mechanism in this process is still unclear. In the present study, we aimed to investigate the dynamic changes of IRAK-M and its protective effects for motor neuron in SOD1-G93A mouse model of ALS. Methods qPCR(Real-time Quantitative PCR Detecting System) were used to examine the mRNA levels of IRAK-M in the spinal cord in both SOD1-G93A mice and their age-matched wild type (WT) littermates at 100 and 140 days of age. we established an adeno-associated virus 9 (AAV9)-based platform by which IRAK-M was targeted mostly to microglial cells to investigate whether this approach could provide a protection in the SOD1-G93A mouse . Results Compared with age-matched WT mice, IRAK-M mRNA level was elevated at 100 and 140 days in the anterior horn region of spinal cords in the SOD1-G93A mouse. AAV9-IRAK-M treated SOD1-G93A mice showed reduction of IL-1β mRNA levels and significant improvements in the numbers of spinal motor neurons in spinal cord. Mice also showed previously reduction of muscle atrophy. Conclusions Our data revealed the dynamic changes of IRAK-M during ALS pathological progression and demonstrated that an AAV9-IRAK-M deliverywas an effective and translatable therapeutic approach for ALS. These findings may help identify potential molecular targets for ALS therapy." @default.
- W4377013334 created "2023-05-19" @default.
- W4377013334 creator A5005470556 @default.
- W4377013334 creator A5021242284 @default.
- W4377013334 creator A5028588380 @default.
- W4377013334 creator A5043892655 @default.
- W4377013334 creator A5054106750 @default.
- W4377013334 creator A5058008743 @default.
- W4377013334 creator A5059575148 @default.
- W4377013334 creator A5064019693 @default.
- W4377013334 date "2023-05-18" @default.
- W4377013334 modified "2023-09-30" @default.
- W4377013334 title "IRAK-M Plays A Role in the Pathology of Amyotrophic Lateral Sclerosis Through Suppressing the Activation of Microglia" @default.
- W4377013334 cites W2002262609 @default.
- W4377013334 cites W2027047473 @default.
- W4377013334 cites W2077331144 @default.
- W4377013334 cites W2079110144 @default.
- W4377013334 cites W2093153238 @default.
- W4377013334 cites W2101321540 @default.
- W4377013334 cites W2118516039 @default.
- W4377013334 cites W2141504417 @default.
- W4377013334 cites W2147758827 @default.
- W4377013334 cites W2166414469 @default.
- W4377013334 cites W2340449812 @default.
- W4377013334 cites W2520105274 @default.
- W4377013334 cites W2556818673 @default.
- W4377013334 cites W2559580747 @default.
- W4377013334 cites W2729880558 @default.
- W4377013334 cites W2905668698 @default.
- W4377013334 cites W2910657247 @default.
- W4377013334 cites W2941500440 @default.
- W4377013334 cites W2952459265 @default.
- W4377013334 cites W3000607767 @default.
- W4377013334 cites W3044057346 @default.
- W4377013334 cites W3133511892 @default.
- W4377013334 cites W4248219898 @default.
- W4377013334 doi "https://doi.org/10.21203/rs.3.rs-2901154/v1" @default.
- W4377013334 hasPublicationYear "2023" @default.
- W4377013334 type Work @default.
- W4377013334 citedByCount "0" @default.
- W4377013334 crossrefType "posted-content" @default.
- W4377013334 hasAuthorship W4377013334A5005470556 @default.
- W4377013334 hasAuthorship W4377013334A5021242284 @default.
- W4377013334 hasAuthorship W4377013334A5028588380 @default.
- W4377013334 hasAuthorship W4377013334A5043892655 @default.
- W4377013334 hasAuthorship W4377013334A5054106750 @default.
- W4377013334 hasAuthorship W4377013334A5058008743 @default.
- W4377013334 hasAuthorship W4377013334A5059575148 @default.
- W4377013334 hasAuthorship W4377013334A5064019693 @default.
- W4377013334 hasBestOaLocation W43770133341 @default.
- W4377013334 hasConcept C142724271 @default.
- W4377013334 hasConcept C169760540 @default.
- W4377013334 hasConcept C203014093 @default.
- W4377013334 hasConcept C2776070231 @default.
- W4377013334 hasConcept C2776752467 @default.
- W4377013334 hasConcept C2776914184 @default.
- W4377013334 hasConcept C2777615887 @default.
- W4377013334 hasConcept C2779134260 @default.
- W4377013334 hasConcept C2779830541 @default.
- W4377013334 hasConcept C2780596555 @default.
- W4377013334 hasConcept C2780775167 @default.
- W4377013334 hasConcept C2781172350 @default.
- W4377013334 hasConcept C71924100 @default.
- W4377013334 hasConcept C86803240 @default.
- W4377013334 hasConceptScore W4377013334C142724271 @default.
- W4377013334 hasConceptScore W4377013334C169760540 @default.
- W4377013334 hasConceptScore W4377013334C203014093 @default.
- W4377013334 hasConceptScore W4377013334C2776070231 @default.
- W4377013334 hasConceptScore W4377013334C2776752467 @default.
- W4377013334 hasConceptScore W4377013334C2776914184 @default.
- W4377013334 hasConceptScore W4377013334C2777615887 @default.
- W4377013334 hasConceptScore W4377013334C2779134260 @default.
- W4377013334 hasConceptScore W4377013334C2779830541 @default.
- W4377013334 hasConceptScore W4377013334C2780596555 @default.
- W4377013334 hasConceptScore W4377013334C2780775167 @default.
- W4377013334 hasConceptScore W4377013334C2781172350 @default.
- W4377013334 hasConceptScore W4377013334C71924100 @default.
- W4377013334 hasConceptScore W4377013334C86803240 @default.
- W4377013334 hasLocation W43770133341 @default.
- W4377013334 hasOpenAccess W4377013334 @default.
- W4377013334 hasPrimaryLocation W43770133341 @default.
- W4377013334 hasRelatedWork W128297183 @default.
- W4377013334 hasRelatedWork W1592247249 @default.
- W4377013334 hasRelatedWork W1966398941 @default.
- W4377013334 hasRelatedWork W1978876260 @default.
- W4377013334 hasRelatedWork W1999641554 @default.
- W4377013334 hasRelatedWork W2399317097 @default.
- W4377013334 hasRelatedWork W3006836401 @default.
- W4377013334 hasRelatedWork W3196901207 @default.
- W4377013334 hasRelatedWork W4286716083 @default.
- W4377013334 hasRelatedWork W4377013334 @default.
- W4377013334 isParatext "false" @default.
- W4377013334 isRetracted "false" @default.
- W4377013334 workType "article" @default.