FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377013413> ?p ?o ?g. }

• W4377013413 abstract "Abstract Faithful transcription of eukaryotic genes by RNA polymerase II (Pol II) is essential for proper cell function. Nevertheless, the integrity of the DNA template of Pol II is continuously challenged by different sources of DNA damage, such as UV-light, that impede transcription. When unresolved, these transcription-blocking lesions (TBLs) can cause cellular dysfunction, senescence and apoptosis, eventually resulting in DNA damage-induced aging. Cells counteract these deleterious effects by Transcription-Coupled Nucleotide Excision Repair (TC-NER), which specifically removes TBLs, thereby safeguarding transcription. TC-NER initiation relies on the concerted actions of the CSB, CSA and UVSSA proteins, and loss of either of these factors results in a complete TC-NER deficiency. Although their TC-NER defect is similar, UVSSA loss results in UV-Sensitive Syndrome (UV S S), with only mild phenotypes like freckling and photosensitivity, while loss of CSA or CSB activity results in the severe Cockayne Syndrome (CS), characterized by premature aging, progressive neurodegeneration and mental retardation. Thus far the underlying mechanism for these striking differences in phenotypes remains unclear. Using live-cell imaging approaches, here we show that in TC-NER proficient cells lesion-stalled Pol II is swiftly resolved by repair of the TBL. However, in CSA and CSB knockout (KO) cells, elongating Pol II remains chromatin-bound. This lesion-stalled Pol II will obstruct other DNA transacting processes and will also shield the damage from repair by alternative pathways. In contrast, in UVSSA KO cells, Pol II is removed from the TBL by VCP-mediated proteasomal degradation, thereby, allowing alternative repair mechanisms to remove the TBL." @default.
• W4377013413 created "2023-05-19" @default.
• W4377013413 creator A5023539579 @default.
• W4377013413 creator A5028929070 @default.
• W4377013413 creator A5045904279 @default.
• W4377013413 creator A5066635533 @default.
• W4377013413 creator A5073743826 @default.
• W4377013413 creator A5075041101 @default.
• W4377013413 creator A5077381400 @default.
• W4377013413 date "2023-05-18" @default.
• W4377013413 modified "2023-09-29" @default.
• W4377013413 title "Prolonged stalling of RNA Polymerase II at DNA damage explains phenotypical differences between Cockayne and UV-sensitive syndromes" @default.
• W4377013413 cites W1563822242 @default.
• W4377013413 cites W1942110646 @default.
• W4377013413 cites W1977982042 @default.
• W4377013413 cites W1984574385 @default.
• W4377013413 cites W1984866675 @default.
• W4377013413 cites W1994300590 @default.
• W4377013413 cites W2003848438 @default.
• W4377013413 cites W2010013021 @default.
• W4377013413 cites W2010556443 @default.
• W4377013413 cites W2013671885 @default.
• W4377013413 cites W2015967593 @default.
• W4377013413 cites W2022431944 @default.
• W4377013413 cites W2034844603 @default.
• W4377013413 cites W2038045924 @default.
• W4377013413 cites W2041615416 @default.
• W4377013413 cites W2046082575 @default.
• W4377013413 cites W2066680666 @default.
• W4377013413 cites W2073274881 @default.
• W4377013413 cites W2074536099 @default.
• W4377013413 cites W2076713615 @default.
• W4377013413 cites W2089243923 @default.
• W4377013413 cites W2092104135 @default.
• W4377013413 cites W2092551932 @default.
• W4377013413 cites W2096136751 @default.
• W4377013413 cites W2099613936 @default.
• W4377013413 cites W2101923550 @default.
• W4377013413 cites W2106443150 @default.
• W4377013413 cites W2109438974 @default.
• W4377013413 cites W2123752358 @default.
• W4377013413 cites W2134597008 @default.
• W4377013413 cites W2143989418 @default.
• W4377013413 cites W2154699761 @default.
• W4377013413 cites W2158534339 @default.
• W4377013413 cites W2161826421 @default.
• W4377013413 cites W2170725518 @default.
• W4377013413 cites W2171613528 @default.
• W4377013413 cites W2275939505 @default.
• W4377013413 cites W2413299070 @default.
• W4377013413 cites W2521236424 @default.
• W4377013413 cites W2557733467 @default.
• W4377013413 cites W2567310142 @default.
• W4377013413 cites W2770404833 @default.
• W4377013413 cites W2774864460 @default.
• W4377013413 cites W2790926106 @default.
• W4377013413 cites W2796775019 @default.
• W4377013413 cites W2977176731 @default.
• W4377013413 cites W2999304916 @default.
• W4377013413 cites W3009266182 @default.
• W4377013413 cites W3009808659 @default.
• W4377013413 cites W3021844846 @default.
• W4377013413 cites W3026190839 @default.
• W4377013413 cites W3108283520 @default.
• W4377013413 cites W3127140457 @default.
• W4377013413 cites W3134357264 @default.
• W4377013413 cites W3169377525 @default.
• W4377013413 cites W3170184056 @default.
• W4377013413 cites W3173330266 @default.
• W4377013413 cites W3183761171 @default.
• W4377013413 cites W3199909334 @default.
• W4377013413 cites W3216063992 @default.
• W4377013413 cites W4283457414 @default.
• W4377013413 cites W4283799404 @default.
• W4377013413 cites W4317517332 @default.
• W4377013413 cites W4318478865 @default.
• W4377013413 doi "https://doi.org/10.1101/2023.05.17.541110" @default.
• W4377013413 hasPublicationYear "2023" @default.
• W4377013413 type Work @default.
• W4377013413 citedByCount "0" @default.
• W4377013413 crossrefType "posted-content" @default.
• W4377013413 hasAuthorship W4377013413A5023539579 @default.
• W4377013413 hasAuthorship W4377013413A5028929070 @default.
• W4377013413 hasAuthorship W4377013413A5045904279 @default.
• W4377013413 hasAuthorship W4377013413A5066635533 @default.
• W4377013413 hasAuthorship W4377013413A5073743826 @default.
• W4377013413 hasAuthorship W4377013413A5075041101 @default.
• W4377013413 hasAuthorship W4377013413A5077381400 @default.
• W4377013413 hasBestOaLocation W43770134131 @default.
• W4377013413 hasConcept C101762097 @default.
• W4377013413 hasConcept C104317684 @default.
• W4377013413 hasConcept C104451858 @default.
• W4377013413 hasConcept C134935766 @default.
• W4377013413 hasConcept C138885662 @default.
• W4377013413 hasConcept C142724271 @default.
• W4377013413 hasConcept C143425029 @default.
• W4377013413 hasConcept C150194340 @default.
• W4377013413 hasConcept C153911025 @default.
• W4377013413 hasConcept C179926584 @default.
• W4377013413 hasConcept C2776925932 @default.

• next