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- W4377013639 abstract "Abstract Recently, nanomaterials, particularly catalase, have gained considerable attention in enhancing the outcomes of cancer therapy. To ensure the efficacious clinical application of catalase, a balance between its stability and biosafety is required alongside the maintenance of a high catalytic efficiency. Herein, halloysite clay nanotubes (HNTs) and dodecahydro-dodecaborate ( closo- [B 12 H 12 ] 2– ) with biocompatible properties were ingeniously combined and reduced in situ to obtain silver nanoparticles (AgNPs) and single-atom nanozyme (SAzyme) composites (HNT@B 12 H 12 @Ag catalase) with significantly good antitumor effect and biosafety. This novel designed material (HNT@B 12 H 12 @Ag) can help avoid the elevated-temperature calcination that is typically employed as it prepares Ag SAzymes alongside AgNPs while maintaining ~ 100% efficiency of Ag utilization via the reducibility and coordination stabilization of closo- [B 12 H 12 ] 2− and HNTs. Moreover, we investigated the catalytic activity and antimelanoma effects of HNT@B 12 H 12 @Ag catalase, and the results revealed that it effectively suppressed melanoma growth in vitro and in vivo via toxic reactive oxygen species generated by mediating the catalytic reactions. This study provides a solid foundation for designing NP/SAzymes with promising clinical translation prospects." @default.
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- W4377013639 date "2023-05-18" @default.
- W4377013639 modified "2023-09-27" @default.
- W4377013639 title "Anti-Tumor Therapy through High ROS Performance induced by Ag Catalase from Boron Cluster with Halloysite Clay Nanotubes" @default.
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- W4377013639 doi "https://doi.org/10.21203/rs.3.rs-2923292/v1" @default.
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