FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377013650> ?p ?o ?g. }

• W4377013650 abstract "Abstract Background DNA methylation plays an important role in life processes by affecting gene expression, but it is still unclear how DNA methylation is controlled and how it regulates gene transcription under high temperature stress conditions in Strongylocentrotus intermedius . The potential link between DNA methylation variation and gene expression changes in response to heat stress in S. intermedius was investigated by MethylRAD-seq and RNA-seq analysis. We screened DNA methylation driver genes in order to comprehensively elucidate the regulatory mechanism of its high temperature adaptation at the DNA/RNA level. Results The results revealed that high temperature stress significantly affected not only the DNA methylation and transcriptome levels of S. intermedius ( P < 0.05), but also growth. Our MethylRAD-seq analysis revealed 12,129 CG differential methylation sites and 966 CWG differential methylation sites, and identified a total of 189 differentially CG methylated genes and 148 differentially CWG methylated genes. Based on KEGG enrichment analysis, differentially expressed genes (DEGs) are mostly enriched in energy and cell division, immune, and neurological damage pathways. Further RNA-seq analysis identified a total of 1968 DEGs, of which 813 genes were upregulated and 1155 genes were downregulated. Based on the joint MethylRAD-seq and RNA-seq analysis, metabolic processes such as glycosaminoglycan degradation, oxidative phosphorylation, apoptosis, glutathione metabolism, thermogenesis, and lysosomes are regulated by DNA methylation. Conclusions High temperature regulates the expression of genes such as MOAP-1 , GGT1 , and RDH8 by interfering with DNA methylation, which in turn affects the metabolism of HPSE, Cox, glutathione, and retinol, thereby suppressing the immune, energy metabolism, and antioxidant functions of the organism and finally manifesting as stunted growth. In summary, the observations in the present study improve our understanding of the molecular mechanism of the response to high temperature stress in sea urchin." @default.
• W4377013650 created "2023-05-19" @default.
• W4377013650 creator A5004632200 @default.
• W4377013650 creator A5011860975 @default.
• W4377013650 creator A5031912829 @default.
• W4377013650 creator A5034388946 @default.
• W4377013650 creator A5039872696 @default.
• W4377013650 creator A5069420670 @default.
• W4377013650 creator A5080194526 @default.
• W4377013650 creator A5084864439 @default.
• W4377013650 creator A5085562803 @default.
• W4377013650 date "2023-05-18" @default.
• W4377013650 modified "2023-10-16" @default.
• W4377013650 title "High temperature influences DNA methylation and transcriptional profiles in sea urchins (Strongylocentrotus intermedius)" @default.
• W4377013650 cites W1566382820 @default.
• W4377013650 cites W1971506569 @default.
• W4377013650 cites W1991515548 @default.
• W4377013650 cites W1996795546 @default.
• W4377013650 cites W1999695626 @default.
• W4377013650 cites W2015640955 @default.
• W4377013650 cites W2028202352 @default.
• W4377013650 cites W2028477742 @default.
• W4377013650 cites W2044186502 @default.
• W4377013650 cites W2044484466 @default.
• W4377013650 cites W2055475863 @default.
• W4377013650 cites W2055654995 @default.
• W4377013650 cites W2063231976 @default.
• W4377013650 cites W2067988341 @default.
• W4377013650 cites W2069455756 @default.
• W4377013650 cites W2071187668 @default.
• W4377013650 cites W2075809877 @default.
• W4377013650 cites W2083832843 @default.
• W4377013650 cites W2102354517 @default.
• W4377013650 cites W2103704928 @default.
• W4377013650 cites W2111884308 @default.
• W4377013650 cites W2115327946 @default.
• W4377013650 cites W2126583974 @default.
• W4377013650 cites W2126934086 @default.
• W4377013650 cites W2130919552 @default.
• W4377013650 cites W2141261198 @default.
• W4377013650 cites W2153330886 @default.
• W4377013650 cites W2157843549 @default.
• W4377013650 cites W2160980758 @default.
• W4377013650 cites W2165567873 @default.
• W4377013650 cites W2239633627 @default.
• W4377013650 cites W2306126377 @default.
• W4377013650 cites W2475926948 @default.
• W4377013650 cites W2759376664 @default.
• W4377013650 cites W2801293399 @default.
• W4377013650 cites W2933475575 @default.
• W4377013650 cites W2979870573 @default.
• W4377013650 cites W3004071169 @default.
• W4377013650 cites W3011223092 @default.
• W4377013650 cites W3013947686 @default.
• W4377013650 cites W3014155635 @default.
• W4377013650 cites W3095558851 @default.
• W4377013650 cites W3118356443 @default.
• W4377013650 cites W4212779701 @default.
• W4377013650 cites W4308152351 @default.
• W4377013650 doi "https://doi.org/10.21203/rs.3.rs-2935452/v1" @default.
• W4377013650 hasPublicationYear "2023" @default.
• W4377013650 type Work @default.
• W4377013650 citedByCount "0" @default.
• W4377013650 crossrefType "posted-content" @default.
• W4377013650 hasAuthorship W4377013650A5004632200 @default.
• W4377013650 hasAuthorship W4377013650A5011860975 @default.
• W4377013650 hasAuthorship W4377013650A5031912829 @default.
• W4377013650 hasAuthorship W4377013650A5034388946 @default.
• W4377013650 hasAuthorship W4377013650A5039872696 @default.
• W4377013650 hasAuthorship W4377013650A5069420670 @default.
• W4377013650 hasAuthorship W4377013650A5080194526 @default.
• W4377013650 hasAuthorship W4377013650A5084864439 @default.
• W4377013650 hasAuthorship W4377013650A5085562803 @default.
• W4377013650 hasBestOaLocation W43770136501 @default.
• W4377013650 hasConcept C104317684 @default.
• W4377013650 hasConcept C116114238 @default.
• W4377013650 hasConcept C121912465 @default.
• W4377013650 hasConcept C150194340 @default.
• W4377013650 hasConcept C153911025 @default.
• W4377013650 hasConcept C154253233 @default.
• W4377013650 hasConcept C162317418 @default.
• W4377013650 hasConcept C163002167 @default.
• W4377013650 hasConcept C165864922 @default.
• W4377013650 hasConcept C190727270 @default.
• W4377013650 hasConcept C33288867 @default.
• W4377013650 hasConcept C41091548 @default.
• W4377013650 hasConcept C54355233 @default.
• W4377013650 hasConcept C86803240 @default.
• W4377013650 hasConceptScore W4377013650C104317684 @default.
• W4377013650 hasConceptScore W4377013650C116114238 @default.
• W4377013650 hasConceptScore W4377013650C121912465 @default.
• W4377013650 hasConceptScore W4377013650C150194340 @default.
• W4377013650 hasConceptScore W4377013650C153911025 @default.
• W4377013650 hasConceptScore W4377013650C154253233 @default.
• W4377013650 hasConceptScore W4377013650C162317418 @default.
• W4377013650 hasConceptScore W4377013650C163002167 @default.
• W4377013650 hasConceptScore W4377013650C165864922 @default.
• W4377013650 hasConceptScore W4377013650C190727270 @default.
• W4377013650 hasConceptScore W4377013650C33288867 @default.
• W4377013650 hasConceptScore W4377013650C41091548 @default.

• next