Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377013842> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W4377013842 endingPage "120" @default.
- W4377013842 startingPage "109" @default.
- W4377013842 abstract "Dental pulp stem cells (DPSCs) and stem cells from human exfoliated deciduous teeth (SHED) are a source of mesenchymal stem cells with the potential to differentiate into several cell types. We initially isolated SHED cells and compared their osteogenic capacity with commercially available DPSCs. Both cells exhibited similar capacities of growth and osteogenic differentiation. A fourfold to sixfold increase in endogenous microRNA26a (miR26a) expression during osteogenic differentiation of preosteoblasts and a similar but attenuated increase (twofold to fourfold) in differentiating SHED was observed, suggesting a role in the process. We, therefore, overexpressed miR26a in SHED to determine if the osteogenic differentiation capacity can be potentiated in vitro. SHED with a threefold increase in miR26a expression showed increased growth rate when compared with parent cells. When exposed to an osteogenic differentiating promoting medium, the miR26a overexpressing cells showed 100-fold increases in the expression of bone marker genes such as type 1 collagen, alkaline phosphatase, and Runx2. The mineralization capacity of these cells was also increased 15-fold. As miR26a targets regulate several bone-specific genes, we evaluated the effect of miR26a overexpression on established targets. We found a moderate decrease in SMAD1 and a profound decrease in PTEN expression. miR26a could potentiate its effect on osteoblast differentiation by its ability to inhibit PTEN and increase the viability of cells and their numbers, a process essential in osteoblast differentiation. Our studies suggest that the upregulation of miR26a can increase bone formation and may serve as an important target to further investigate its potential in tissue engineering applications." @default.
- W4377013842 created "2023-05-19" @default.
- W4377013842 creator A5041430358 @default.
- W4377013842 creator A5050301524 @default.
- W4377013842 creator A5055740521 @default.
- W4377013842 creator A5066569524 @default.
- W4377013842 date "2023-06-01" @default.
- W4377013842 modified "2023-09-29" @default.
- W4377013842 title "MicroRNA26a Overexpression Hastens Osteoblast Differentiation Capacity in Dental Stem Cells" @default.
- W4377013842 cites W1578296754 @default.
- W4377013842 cites W2014549124 @default.
- W4377013842 cites W2034297562 @default.
- W4377013842 cites W2042060958 @default.
- W4377013842 cites W2060013770 @default.
- W4377013842 cites W2072402308 @default.
- W4377013842 cites W2076287538 @default.
- W4377013842 cites W2079452905 @default.
- W4377013842 cites W2098563348 @default.
- W4377013842 cites W2100337149 @default.
- W4377013842 cites W2103346550 @default.
- W4377013842 cites W2159807040 @default.
- W4377013842 cites W2160102037 @default.
- W4377013842 cites W2162088346 @default.
- W4377013842 cites W2289072239 @default.
- W4377013842 cites W2617196371 @default.
- W4377013842 cites W2767343845 @default.
- W4377013842 cites W2925314732 @default.
- W4377013842 cites W2998665787 @default.
- W4377013842 cites W3038018302 @default.
- W4377013842 cites W3047630593 @default.
- W4377013842 cites W3082966689 @default.
- W4377013842 cites W3094376574 @default.
- W4377013842 cites W3102741408 @default.
- W4377013842 cites W3113011624 @default.
- W4377013842 cites W3128093554 @default.
- W4377013842 cites W3163895741 @default.
- W4377013842 cites W3206278674 @default.
- W4377013842 cites W38795132 @default.
- W4377013842 cites W4205515993 @default.
- W4377013842 cites W962052387 @default.
- W4377013842 doi "https://doi.org/10.1089/cell.2023.0004" @default.
- W4377013842 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37200520" @default.
- W4377013842 hasPublicationYear "2023" @default.
- W4377013842 type Work @default.
- W4377013842 citedByCount "0" @default.
- W4377013842 crossrefType "journal-article" @default.
- W4377013842 hasAuthorship W4377013842A5041430358 @default.
- W4377013842 hasAuthorship W4377013842A5050301524 @default.
- W4377013842 hasAuthorship W4377013842A5055740521 @default.
- W4377013842 hasAuthorship W4377013842A5066569524 @default.
- W4377013842 hasConcept C104317684 @default.
- W4377013842 hasConcept C148738053 @default.
- W4377013842 hasConcept C160160445 @default.
- W4377013842 hasConcept C181199279 @default.
- W4377013842 hasConcept C198826908 @default.
- W4377013842 hasConcept C202751555 @default.
- W4377013842 hasConcept C2776363554 @default.
- W4377013842 hasConcept C2777400515 @default.
- W4377013842 hasConcept C2778260815 @default.
- W4377013842 hasConcept C28328180 @default.
- W4377013842 hasConcept C55493867 @default.
- W4377013842 hasConcept C86803240 @default.
- W4377013842 hasConcept C95444343 @default.
- W4377013842 hasConceptScore W4377013842C104317684 @default.
- W4377013842 hasConceptScore W4377013842C148738053 @default.
- W4377013842 hasConceptScore W4377013842C160160445 @default.
- W4377013842 hasConceptScore W4377013842C181199279 @default.
- W4377013842 hasConceptScore W4377013842C198826908 @default.
- W4377013842 hasConceptScore W4377013842C202751555 @default.
- W4377013842 hasConceptScore W4377013842C2776363554 @default.
- W4377013842 hasConceptScore W4377013842C2777400515 @default.
- W4377013842 hasConceptScore W4377013842C2778260815 @default.
- W4377013842 hasConceptScore W4377013842C28328180 @default.
- W4377013842 hasConceptScore W4377013842C55493867 @default.
- W4377013842 hasConceptScore W4377013842C86803240 @default.
- W4377013842 hasConceptScore W4377013842C95444343 @default.
- W4377013842 hasIssue "3" @default.
- W4377013842 hasLocation W43770138421 @default.
- W4377013842 hasLocation W43770138422 @default.
- W4377013842 hasOpenAccess W4377013842 @default.
- W4377013842 hasPrimaryLocation W43770138421 @default.
- W4377013842 hasRelatedWork W2012475213 @default.
- W4377013842 hasRelatedWork W2024197203 @default.
- W4377013842 hasRelatedWork W2162168964 @default.
- W4377013842 hasRelatedWork W2310330668 @default.
- W4377013842 hasRelatedWork W2325510318 @default.
- W4377013842 hasRelatedWork W2562818108 @default.
- W4377013842 hasRelatedWork W2783297797 @default.
- W4377013842 hasRelatedWork W2913570652 @default.
- W4377013842 hasRelatedWork W3005242938 @default.
- W4377013842 hasRelatedWork W4378640045 @default.
- W4377013842 hasVolume "25" @default.
- W4377013842 isParatext "false" @default.
- W4377013842 isRetracted "false" @default.
- W4377013842 workType "article" @default.