FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4377013931> ?p ?o ?g. }

• W4377013931 abstract "Abstract Motivation Genome-wide association interaction studies (GWAIS) are becoming increasingly important as estimates of genetic interactions at the genome-wide level using genome-wide data from hundreds of thousands of individuals from large biobanks showed that non-additive genetic variance plays a role in complex human traits in addition to additive genetic effects identified in genome-wide association studies (GWAS). However, a comprehensive genome-wide search for all combinations of second-order (SNPxSNP) or third-order (SNPxSNPxSNP) associations using millions of SNP markers is a very computationally intensive task, especially when hundreds of thousands or, in the near future, even millions of individuals can be studied with GWAS datasets. The runtime so far exceeds years, even if the search is performed on a multicore CPU server system. Results We developed GWAIS-Web , a web service for fast analysis of genome-wide interactions with case-control GWAS datasets. By using a hybrid combination of graphics-processing units (GPUs) and field-programmable gate arrays (FPGAs), GWAIS-Web speeds up epistasis detection methods for binary traits by a factor of more than 2000, allowing an exhaustive SNP-SNP GWAIS with a GWAS data set of one million SNPs and 500,000 individuals to complete within one day, which would take more than five years on a regular CPU server system. The user can choose between different methods for epistasis detection, such as logistic regression, BOOST, mutual information (MI) and others, with calculations in double precision and including on-the-fly filtering of correlated results based on linkage disequilibrium (LD). Due to the underlying common data structure of GWAIS-Web , all methods can be combined and processed together on-the-fly without increasing the runtime. The user can choose between 2nd order (pairwise) and 3rd order tests and can also limit the search to selected chromosomal regions. GWAIS-Web offers a high level of security through optional 2-factor authentication, encrypted connections and the protection of GWAS/user account data in accordance with the European General Data Protection Regulation (GDPR). Availability GWAIS-Web is freely available at https://hybridcomputing.ikmb.uni-kiel.de . The stand-alone software HybridGWAIS can be downloaded at https://github.com/ikmb/hybridgwais . Supplementary information Supplementary data are available online." @default.
• W4377013931 created "2023-05-19" @default.
• W4377013931 creator A5003785979 @default.
• W4377013931 creator A5012331187 @default.
• W4377013931 creator A5058128474 @default.
• W4377013931 date "2023-05-18" @default.
• W4377013931 modified "2023-09-29" @default.
• W4377013931 title "<i>GWAIS-Web</i>: A Fast and Secure Web Service for Epistasis Detection in Genome-wide Association Interaction Studies" @default.
• W4377013931 cites W1822695366 @default.
• W4377013931 cites W1971299565 @default.
• W4377013931 cites W2037098416 @default.
• W4377013931 cites W2093217973 @default.
• W4377013931 cites W2105842551 @default.
• W4377013931 cites W2131682733 @default.
• W4377013931 cites W2140249224 @default.
• W4377013931 cites W2156459362 @default.
• W4377013931 cites W2161633633 @default.
• W4377013931 cites W2883415719 @default.
• W4377013931 cites W2906166739 @default.
• W4377013931 cites W2944540884 @default.
• W4377013931 cites W2971177113 @default.
• W4377013931 cites W3147973671 @default.
• W4377013931 doi "https://doi.org/10.1101/2023.05.16.540964" @default.
• W4377013931 hasPublicationYear "2023" @default.
• W4377013931 type Work @default.
• W4377013931 citedByCount "0" @default.
• W4377013931 crossrefType "posted-content" @default.
• W4377013931 hasAuthorship W4377013931A5003785979 @default.
• W4377013931 hasAuthorship W4377013931A5012331187 @default.
• W4377013931 hasAuthorship W4377013931A5058128474 @default.
• W4377013931 hasBestOaLocation W43770139311 @default.
• W4377013931 hasConcept C104317684 @default.
• W4377013931 hasConcept C106208931 @default.
• W4377013931 hasConcept C110875604 @default.
• W4377013931 hasConcept C111919701 @default.
• W4377013931 hasConcept C11392498 @default.
• W4377013931 hasConcept C124101348 @default.
• W4377013931 hasConcept C135763542 @default.
• W4377013931 hasConcept C153209595 @default.
• W4377013931 hasConcept C186413461 @default.
• W4377013931 hasConcept C35605836 @default.
• W4377013931 hasConcept C41008148 @default.
• W4377013931 hasConcept C54355233 @default.
• W4377013931 hasConcept C61727976 @default.
• W4377013931 hasConcept C86803240 @default.
• W4377013931 hasConceptScore W4377013931C104317684 @default.
• W4377013931 hasConceptScore W4377013931C106208931 @default.
• W4377013931 hasConceptScore W4377013931C110875604 @default.
• W4377013931 hasConceptScore W4377013931C111919701 @default.
• W4377013931 hasConceptScore W4377013931C11392498 @default.
• W4377013931 hasConceptScore W4377013931C124101348 @default.
• W4377013931 hasConceptScore W4377013931C135763542 @default.
• W4377013931 hasConceptScore W4377013931C153209595 @default.
• W4377013931 hasConceptScore W4377013931C186413461 @default.
• W4377013931 hasConceptScore W4377013931C35605836 @default.
• W4377013931 hasConceptScore W4377013931C41008148 @default.
• W4377013931 hasConceptScore W4377013931C54355233 @default.
• W4377013931 hasConceptScore W4377013931C61727976 @default.
• W4377013931 hasConceptScore W4377013931C86803240 @default.
• W4377013931 hasLocation W43770139311 @default.
• W4377013931 hasOpenAccess W4377013931 @default.
• W4377013931 hasPrimaryLocation W43770139311 @default.
• W4377013931 hasRelatedWork W2069221540 @default.
• W4377013931 hasRelatedWork W2084142217 @default.
• W4377013931 hasRelatedWork W2290917873 @default.
• W4377013931 hasRelatedWork W2517753256 @default.
• W4377013931 hasRelatedWork W2727180246 @default.
• W4377013931 hasRelatedWork W2786051698 @default.
• W4377013931 hasRelatedWork W2979461462 @default.
• W4377013931 hasRelatedWork W3082362785 @default.
• W4377013931 hasRelatedWork W3132297604 @default.
• W4377013931 hasRelatedWork W4311691720 @default.
• W4377013931 isParatext "false" @default.
• W4377013931 isRetracted "false" @default.
• W4377013931 workType "article" @default.